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Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases.

Abstract

AIM

To investigate the effect of vitamin D (VD) concentrations and VD supplementation on health related quality of life in inflammatory bowel disease (IBD) patients.

METHODS

A cohort of 220 IBD patients including 141 Crohn's disease (CD) and 79 ulcerative colitis (UC) patients was followed-up at a tertiary IBD center. A subgroup of the cohort (n = 26) took VD supplements for > 3 mo. Health related quality of life was assessed using the short IBD questionnaire (sIBDQ). VD serum concentration and sIBDQ score were assessed between August and October 2012 (summer/autumn period) and between February and April 2013 (winter/spring period). The mean VD serum concentration and its correlation with disease activity of CD were determined for each season separately. In a subgroup of patients, the effects of VD supplementation on winter VD serum concentration, change in VD serum concentration from summer to winter, and winter sIBDQ score were analyzed.

RESULTS

During the summer/autumn and the winter/spring period, 28% and 42% of IBD patients were VD-deficient (< 20 ng/mL), respectively. In the winter/spring period, there was a significant correlation between sIBDQ score and VD serum concentration in UC patients (r = 0.35, P = 0.02), with a trend towards significance in CD patients (r = 0.17, P = 0.06). In the winter/spring period, VD-insufficient patients (< 30 ng/mL) had a significantly lower mean sIBDQ score than VD-sufficient patients; this was true of both UC (48.3 ± 2.3 vs 56.7 ± 3.4, P = 0.04) and CD (55.7 ± 1.25 vs 60.8 ± 2.14, P = 0.04) patients. In all analyzed scenarios (UC/CD, the summer/autumn period and the winter/spring period), health related quality of life was the highest in patients with VD serum concentrations of 50-59 ng/mL. Supplementation with a median of 800 IU/d VD day did not influence VD serum concentration or the sIBDQ score.

CONCLUSION

VD serum concentration correlated with health related quality of life in UC and CD patients during the winter/spring period.

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  • Authors+Show Affiliations

    ,

    Tibor Hlavaty, Anna Krajcovicova, Tomas Koller, Jozef Toth, Monika Nevidanska, Martin Huorka, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Bratislava, Ruzinov, 82606 Bratislava, Slovakia.

    ,

    Tibor Hlavaty, Anna Krajcovicova, Tomas Koller, Jozef Toth, Monika Nevidanska, Martin Huorka, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Bratislava, Ruzinov, 82606 Bratislava, Slovakia.

    ,

    Tibor Hlavaty, Anna Krajcovicova, Tomas Koller, Jozef Toth, Monika Nevidanska, Martin Huorka, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Bratislava, Ruzinov, 82606 Bratislava, Slovakia.

    ,

    Tibor Hlavaty, Anna Krajcovicova, Tomas Koller, Jozef Toth, Monika Nevidanska, Martin Huorka, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Bratislava, Ruzinov, 82606 Bratislava, Slovakia.

    ,

    Tibor Hlavaty, Anna Krajcovicova, Tomas Koller, Jozef Toth, Monika Nevidanska, Martin Huorka, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Bratislava, Ruzinov, 82606 Bratislava, Slovakia.

    ,

    Tibor Hlavaty, Anna Krajcovicova, Tomas Koller, Jozef Toth, Monika Nevidanska, Martin Huorka, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Bratislava, Ruzinov, 82606 Bratislava, Slovakia.

    Tibor Hlavaty, Anna Krajcovicova, Tomas Koller, Jozef Toth, Monika Nevidanska, Martin Huorka, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Bratislava, Ruzinov, 82606 Bratislava, Slovakia.

    Source

    World journal of gastroenterology 20:42 2014 Nov 14 pg 15787-96

    MeSH

    Adult
    Biomarkers
    Calcifediol
    Colitis, Ulcerative
    Crohn Disease
    Dietary Supplements
    Female
    Humans
    Male
    Middle Aged
    Prevalence
    Quality of Life
    Retrospective Studies
    Seasons
    Severity of Illness Index
    Slovakia
    Surveys and Questionnaires
    Tertiary Care Centers
    Time Factors
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Comparative Study
    Journal Article
    Observational Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25400464

    Citation

    Hlavaty, Tibor, et al. "Higher Vitamin D Serum Concentration Increases Health Related Quality of Life in Patients With Inflammatory Bowel Diseases." World Journal of Gastroenterology, vol. 20, no. 42, 2014, pp. 15787-96.
    Hlavaty T, Krajcovicova A, Koller T, et al. Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases. World J Gastroenterol. 2014;20(42):15787-96.
    Hlavaty, T., Krajcovicova, A., Koller, T., Toth, J., Nevidanska, M., Huorka, M., & Payer, J. (2014). Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases. World Journal of Gastroenterology, 20(42), pp. 15787-96. doi:10.3748/wjg.v20.i42.15787.
    Hlavaty T, et al. Higher Vitamin D Serum Concentration Increases Health Related Quality of Life in Patients With Inflammatory Bowel Diseases. World J Gastroenterol. 2014 Nov 14;20(42):15787-96. PubMed PMID: 25400464.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases. AU - Hlavaty,Tibor, AU - Krajcovicova,Anna, AU - Koller,Tomas, AU - Toth,Jozef, AU - Nevidanska,Monika, AU - Huorka,Martin, AU - Payer,Juraj, PY - 2014/04/01/received PY - 2014/05/21/revised PY - 2014/06/13/accepted PY - 2014/11/18/entrez PY - 2014/11/18/pubmed PY - 2015/8/19/medline KW - Crohn’s disease KW - Health related quality of life KW - Ulcerative colitis KW - Vitamin D KW - Vitamin D supplementation SP - 15787 EP - 96 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 20 IS - 42 N2 - AIM: To investigate the effect of vitamin D (VD) concentrations and VD supplementation on health related quality of life in inflammatory bowel disease (IBD) patients. METHODS: A cohort of 220 IBD patients including 141 Crohn's disease (CD) and 79 ulcerative colitis (UC) patients was followed-up at a tertiary IBD center. A subgroup of the cohort (n = 26) took VD supplements for > 3 mo. Health related quality of life was assessed using the short IBD questionnaire (sIBDQ). VD serum concentration and sIBDQ score were assessed between August and October 2012 (summer/autumn period) and between February and April 2013 (winter/spring period). The mean VD serum concentration and its correlation with disease activity of CD were determined for each season separately. In a subgroup of patients, the effects of VD supplementation on winter VD serum concentration, change in VD serum concentration from summer to winter, and winter sIBDQ score were analyzed. RESULTS: During the summer/autumn and the winter/spring period, 28% and 42% of IBD patients were VD-deficient (< 20 ng/mL), respectively. In the winter/spring period, there was a significant correlation between sIBDQ score and VD serum concentration in UC patients (r = 0.35, P = 0.02), with a trend towards significance in CD patients (r = 0.17, P = 0.06). In the winter/spring period, VD-insufficient patients (< 30 ng/mL) had a significantly lower mean sIBDQ score than VD-sufficient patients; this was true of both UC (48.3 ± 2.3 vs 56.7 ± 3.4, P = 0.04) and CD (55.7 ± 1.25 vs 60.8 ± 2.14, P = 0.04) patients. In all analyzed scenarios (UC/CD, the summer/autumn period and the winter/spring period), health related quality of life was the highest in patients with VD serum concentrations of 50-59 ng/mL. Supplementation with a median of 800 IU/d VD day did not influence VD serum concentration or the sIBDQ score. CONCLUSION: VD serum concentration correlated with health related quality of life in UC and CD patients during the winter/spring period. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/25400464/Higher_vitamin_D_serum_concentration_increases_health_related_quality_of_life_in_patients_with_inflammatory_bowel_diseases_ L2 - http://www.wjgnet.com/1007-9327/full/v20/i42/15787.htm DB - PRIME DP - Unbound Medicine ER -