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Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives.
Isr J Med Sci 1989; 25(3):142-5IJ

Abstract

A 34-year-old woman developed megaloblastic anemia and peripheral polyneuropathy following the use of oral contraceptives for 4 years. Low levels of folic acid and vitamin B12 were found. Both the complete recovery after therapy with the vitamins, and the absence of other causes of vitamin B12 and folate deficiency, suggest that the vitamin deficiencies were caused by the oral contraceptives and resulted in the rare combination of megaloblastic anemia and polyneuropathy. The poor response to vitamin B12 alone, and the development of anemia and polyneuropathy 4 months after cessation of vitamin B12 therapy suggest that folate deficiency was the primary problem.

Authors+Show Affiliations

Department of Hematology, Assaf Harofeh Medical Center, Zerifin, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2540115

Citation

Kornberg, A, et al. "Folic Acid Deficiency, Megaloblastic Anemia and Peripheral Polyneuropathy Due to Oral Contraceptives." Israel Journal of Medical Sciences, vol. 25, no. 3, 1989, pp. 142-5.
Kornberg A, Segal R, Theitler J, et al. Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives. Isr J Med Sci. 1989;25(3):142-5.
Kornberg, A., Segal, R., Theitler, J., Yona, R., & Kaufman, S. (1989). Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives. Israel Journal of Medical Sciences, 25(3), pp. 142-5.
Kornberg A, et al. Folic Acid Deficiency, Megaloblastic Anemia and Peripheral Polyneuropathy Due to Oral Contraceptives. Isr J Med Sci. 1989;25(3):142-5. PubMed PMID: 2540115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives. AU - Kornberg,A, AU - Segal,R, AU - Theitler,J, AU - Yona,R, AU - Kaufman,S, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez KW - Biology KW - Case Studies KW - Contraception KW - Contraceptive Methods--side effects KW - Examinations And Diagnoses KW - Family Planning KW - Hematological Effects KW - Hemic System KW - Laboratory Examinations And Diagnoses KW - Neurologic Effects KW - Oral Contraceptives--side effects KW - Physiology KW - Research Methodology KW - Serum Folate Level--analysis KW - Studies KW - Vitamin B Complex--analysis KW - Vitamins SP - 142 EP - 5 JF - Israel journal of medical sciences JO - Isr. J. Med. Sci. VL - 25 IS - 3 N2 - A 34-year-old woman developed megaloblastic anemia and peripheral polyneuropathy following the use of oral contraceptives for 4 years. Low levels of folic acid and vitamin B12 were found. Both the complete recovery after therapy with the vitamins, and the absence of other causes of vitamin B12 and folate deficiency, suggest that the vitamin deficiencies were caused by the oral contraceptives and resulted in the rare combination of megaloblastic anemia and polyneuropathy. The poor response to vitamin B12 alone, and the development of anemia and polyneuropathy 4 months after cessation of vitamin B12 therapy suggest that folate deficiency was the primary problem. SN - 0021-2180 UR - https://www.unboundmedicine.com/medline/citation/2540115/Folic_acid_deficiency_megaloblastic_anemia_and_peripheral_polyneuropathy_due_to_oral_contraceptives_ L2 - http://www.diseaseinfosearch.org/result/4562 DB - PRIME DP - Unbound Medicine ER -