Tags

Type your tag names separated by a space and hit enter

Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: assessment of non-invasive indices predicting hepatic steatosis and fibrosis.

Abstract

OBJECTIVE

Insulin resistance contributes to the pathogenesis of both polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD). The main aim of the present study was the evaluation of non-invasive indices of hepatic steatosis and fibrosis in PCOS women with or without metabolic syndrome (MetS).

DESIGN

In this cross-sectional study, three non-invasive indices for hepatic steatosis [NAFLD liver fat score, lipid accumulation product (LAP) and hepatic steatosis index (HIS)] and four for fibrosis [FIB-4, aspartate aminotransferase (AST)-to-Platelet Ratio Index (APRI), body mass index (BMI)-Age-Alanine aminotransferase (ALT)-Triglycerides (BAAT) and BMI AST/ALT Ratio Diabetes (BARD)] were calculated in 314 PCOS women (77 with, 237 without MetS) and 78 controls.

RESULTS

All steatosis indices were significantly higher in the PCOS than the control group (NAFLD liver fat score: -0.139 ± 0.117 vs. -0.976 ± 0.159, p<0.001; LAP: 43.3 ± 1.9 vs. 34.7 ± 3.1, p=0.036; HIS: 44.6 ± 0.5 vs. 42.1 ± 0.8, p=0.016). FIB-4 and BAAT [fibrosis stage (F)2-4] were higher in the PCOS group (0.480 ± 0.020 vs. 0.400 ± 0.013, p<0.001; and 15.6% vs. 5.1%, respectively), whereas APRI and BARD were not. All steatosis indices were significantly higher in PCOS women with than without MetS (NAFLD liver fat score: 1.874 ± 0.258 vs. -0.793 ± 0.099, p<0.001; LAP: 76.8 ± 4.9 vs. 33.4 ± 1.4, p<0.001; and HIS: 49.8 ± 1 vs. 43 ± 0.5, p<0.001). Of the fibrosis indices, only BAAT (F2-4: 50.6% vs. 4.2%) was higher in PCOS women with MetS.

CONCLUSIONS

Non-invasive indices of hepatic steatosis were significantly higher in PCOS, especially in the presence of MetS, whereas indices of hepatic fibrosis yielded controversial results. Further studies are warranted to evaluate the long-term outcomes of hepatic steatosis and fibrosis indices in PCOS women.

Links

  • FREE Publisher Full Text
  • Publisher Full Text
  • Authors

    , , , , , , ,

    Source

    MeSH

    Adult
    Alanine Transaminase
    Case-Control Studies
    Cross-Sectional Studies
    Fatty Liver
    Female
    Health Status Indicators
    Humans
    Liver Cirrhosis
    Non-alcoholic Fatty Liver Disease
    Polycystic Ovary Syndrome
    Prognosis
    Retrospective Studies
    Triglycerides

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    25402369

    Citation

    Polyzos, Stergios A., et al. "Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome: Assessment of Non-invasive Indices Predicting Hepatic Steatosis and Fibrosis." Hormones (Athens, Greece), vol. 13, no. 4, 2014, pp. 519-31.
    Polyzos SA, Goulis DG, Kountouras J, et al. Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: assessment of non-invasive indices predicting hepatic steatosis and fibrosis. Hormones (Athens). 2014;13(4):519-31.
    Polyzos, S. A., Goulis, D. G., Kountouras, J., Mintziori, G., Chatzis, P., Papadakis, E., ... Panidis, D. (2014). Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: assessment of non-invasive indices predicting hepatic steatosis and fibrosis. Hormones (Athens, Greece), 13(4), pp. 519-31. doi:10.14310/horm.2002.1493.
    Polyzos SA, et al. Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome: Assessment of Non-invasive Indices Predicting Hepatic Steatosis and Fibrosis. Hormones (Athens). 2014;13(4):519-31. PubMed PMID: 25402369.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: assessment of non-invasive indices predicting hepatic steatosis and fibrosis. AU - Polyzos,Stergios A, AU - Goulis,Dimitrios G, AU - Kountouras,Jannis, AU - Mintziori,Gesthimani, AU - Chatzis,Panagiotis, AU - Papadakis,Efstathios, AU - Katsikis,Ilias, AU - Panidis,Dimitrios, Y1 - 2014/11/05/ PY - 2013/11/27/received PY - 2014/02/20/accepted PY - 2014/11/18/entrez PY - 2014/11/18/pubmed PY - 2015/10/2/medline SP - 519 EP - 31 JF - Hormones (Athens, Greece) JO - Hormones (Athens) VL - 13 IS - 4 N2 - OBJECTIVE: Insulin resistance contributes to the pathogenesis of both polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD). The main aim of the present study was the evaluation of non-invasive indices of hepatic steatosis and fibrosis in PCOS women with or without metabolic syndrome (MetS). DESIGN: In this cross-sectional study, three non-invasive indices for hepatic steatosis [NAFLD liver fat score, lipid accumulation product (LAP) and hepatic steatosis index (HIS)] and four for fibrosis [FIB-4, aspartate aminotransferase (AST)-to-Platelet Ratio Index (APRI), body mass index (BMI)-Age-Alanine aminotransferase (ALT)-Triglycerides (BAAT) and BMI AST/ALT Ratio Diabetes (BARD)] were calculated in 314 PCOS women (77 with, 237 without MetS) and 78 controls. RESULTS: All steatosis indices were significantly higher in the PCOS than the control group (NAFLD liver fat score: -0.139 ± 0.117 vs. -0.976 ± 0.159, p<0.001; LAP: 43.3 ± 1.9 vs. 34.7 ± 3.1, p=0.036; HIS: 44.6 ± 0.5 vs. 42.1 ± 0.8, p=0.016). FIB-4 and BAAT [fibrosis stage (F)2-4] were higher in the PCOS group (0.480 ± 0.020 vs. 0.400 ± 0.013, p<0.001; and 15.6% vs. 5.1%, respectively), whereas APRI and BARD were not. All steatosis indices were significantly higher in PCOS women with than without MetS (NAFLD liver fat score: 1.874 ± 0.258 vs. -0.793 ± 0.099, p<0.001; LAP: 76.8 ± 4.9 vs. 33.4 ± 1.4, p<0.001; and HIS: 49.8 ± 1 vs. 43 ± 0.5, p<0.001). Of the fibrosis indices, only BAAT (F2-4: 50.6% vs. 4.2%) was higher in PCOS women with MetS. CONCLUSIONS: Non-invasive indices of hepatic steatosis were significantly higher in PCOS, especially in the presence of MetS, whereas indices of hepatic fibrosis yielded controversial results. Further studies are warranted to evaluate the long-term outcomes of hepatic steatosis and fibrosis indices in PCOS women. SN - 2520-8721 UR - https://www.unboundmedicine.com/medline/citation/25402369/Non_alcoholic_fatty_liver_disease_in_women_with_polycystic_ovary_syndrome:_assessment_of_non_invasive_indices_predicting_hepatic_steatosis_and_fibrosis_ L2 - http://hormones.gr/preview.php?c_id=8508 DB - PRIME DP - Unbound Medicine ER -