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Dietary glycemic index and glycemic load and risk of colorectal cancer: results from the EPIC-Italy study.
Int J Cancer 2015; 136(12):2923-31IJ

Abstract

A carbohydrate-rich diet, resulting in high blood glucose and insulin, has been hypothesized as involved in colorectal cancer etiology. We investigated dietary glycemic index (GI) and glycemic load (GL), in relation to colorectal cancer, in the prospectively recruited EPIC-Italy cohort. After a median 11.7 years, 421 colorectal cancers were diagnosed among 47,749 recruited adults. GI and GL were estimated from validated food frequency questionnaires. Multivariable Cox modeling estimated hazard ratios (HRs) for associations between colorectal cancer and intakes of total, high GI and low GI carbohydrate and GI and GL. The adjusted HR of colorectal cancer for highest versus lowest GI quartile was 1.35; 95% confidence interval (CI) 1.03-1.78; p trend 0.031. Increasing high GI carbohydrate intake was also significantly associated with increasing colorectal cancer risk (HR 1.45; 95% CI 1.04-2.03; p trend 0.034), whereas increasing low GI carbohydrate was associated with reducing risk (HR 0.73; 95% CI 0.54-0.98; p trend 0.033). High dietary GI and high GI carbohydrate were associated with increased risks of cancer at all colon sites (HR 1.37; 95% CI 1.00-1.88, HR 1.80; 95% CI 1.22-2.65, respectively), whereas high GI carbohydrate and high GL were associated with increased risk of proximal colon cancer (HR 1.94; 95% CI 1.18-3.16, HR 2.01; 95% CI 1.08-3.74, respectively). After stratification for waist-to-hip ratio (WHR), cancer was significantly associated with GI, and high GI carbohydrate, in those with high WHR. These findings suggest that high dietary GI and high carbohydrate intake from high GI foods are associated with increased risk of colorectal cancer.

Authors+Show Affiliations

Department of Preventive & Predictive Medicine, Epidemiology and Prevention Unit, Fondazione IRCSS Istituto Nazionale dei Tumori, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25403784

Citation

Sieri, S, et al. "Dietary Glycemic Index and Glycemic Load and Risk of Colorectal Cancer: Results From the EPIC-Italy Study." International Journal of Cancer, vol. 136, no. 12, 2015, pp. 2923-31.
Sieri S, Krogh V, Agnoli C, et al. Dietary glycemic index and glycemic load and risk of colorectal cancer: results from the EPIC-Italy study. Int J Cancer. 2015;136(12):2923-31.
Sieri, S., Krogh, V., Agnoli, C., Ricceri, F., Palli, D., Masala, G., ... Sacerdote, C. (2015). Dietary glycemic index and glycemic load and risk of colorectal cancer: results from the EPIC-Italy study. International Journal of Cancer, 136(12), pp. 2923-31. doi:10.1002/ijc.29341.
Sieri S, et al. Dietary Glycemic Index and Glycemic Load and Risk of Colorectal Cancer: Results From the EPIC-Italy Study. Int J Cancer. 2015 Jun 15;136(12):2923-31. PubMed PMID: 25403784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary glycemic index and glycemic load and risk of colorectal cancer: results from the EPIC-Italy study. AU - Sieri,S, AU - Krogh,V, AU - Agnoli,C, AU - Ricceri,F, AU - Palli,D, AU - Masala,G, AU - Panico,S, AU - Mattiello,A, AU - Tumino,R, AU - Giurdanella,M C, AU - Brighenti,F, AU - Scazzina,F, AU - Vineis,P, AU - Sacerdote,C, Y1 - 2014/11/25/ PY - 2014/08/11/received PY - 2014/11/07/accepted PY - 2014/11/19/entrez PY - 2014/11/19/pubmed PY - 2015/6/24/medline KW - colorectal cancer KW - dietary carbohydrates KW - epidemiology KW - glycemic index KW - glycemic load SP - 2923 EP - 31 JF - International journal of cancer JO - Int. J. Cancer VL - 136 IS - 12 N2 - A carbohydrate-rich diet, resulting in high blood glucose and insulin, has been hypothesized as involved in colorectal cancer etiology. We investigated dietary glycemic index (GI) and glycemic load (GL), in relation to colorectal cancer, in the prospectively recruited EPIC-Italy cohort. After a median 11.7 years, 421 colorectal cancers were diagnosed among 47,749 recruited adults. GI and GL were estimated from validated food frequency questionnaires. Multivariable Cox modeling estimated hazard ratios (HRs) for associations between colorectal cancer and intakes of total, high GI and low GI carbohydrate and GI and GL. The adjusted HR of colorectal cancer for highest versus lowest GI quartile was 1.35; 95% confidence interval (CI) 1.03-1.78; p trend 0.031. Increasing high GI carbohydrate intake was also significantly associated with increasing colorectal cancer risk (HR 1.45; 95% CI 1.04-2.03; p trend 0.034), whereas increasing low GI carbohydrate was associated with reducing risk (HR 0.73; 95% CI 0.54-0.98; p trend 0.033). High dietary GI and high GI carbohydrate were associated with increased risks of cancer at all colon sites (HR 1.37; 95% CI 1.00-1.88, HR 1.80; 95% CI 1.22-2.65, respectively), whereas high GI carbohydrate and high GL were associated with increased risk of proximal colon cancer (HR 1.94; 95% CI 1.18-3.16, HR 2.01; 95% CI 1.08-3.74, respectively). After stratification for waist-to-hip ratio (WHR), cancer was significantly associated with GI, and high GI carbohydrate, in those with high WHR. These findings suggest that high dietary GI and high carbohydrate intake from high GI foods are associated with increased risk of colorectal cancer. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/25403784/Dietary_glycemic_index_and_glycemic_load_and_risk_of_colorectal_cancer:_results_from_the_EPIC_Italy_study_ L2 - https://doi.org/10.1002/ijc.29341 DB - PRIME DP - Unbound Medicine ER -