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Lifetime alcohol consumption and upper aero-digestive tract cancer risk in the Melbourne Collaborative Cohort Study.
Cancer Causes Control 2015; 26(2):297-301CC

Abstract

PURPOSE

Cohort studies have rarely examined the association between upper aero-digestive tract (UADT) cancer risk and lifetime alcohol intake. We examined the associations between incident squamous cell carcinoma of the UADT (oral cavity, pharynx, larynx, and esophagus) and alcohol intake for different periods in life using data from the Melbourne Collaborative Cohort Study.

METHODS

Usual alcohol intake for 10-year periods from age 20 was calculated using recalled frequency and quantity of beverage-specific consumption. Cox regression with age as the time axis was performed to estimate hazard ratios (HR) and 95 % confidence intervals (CI) for the associations of UADT cancer with alcohol intake for different periods in life compared with abstention.

RESULTS

During a mean follow-up of 16.2 person-years, 98 incident cases of UADT cancer were identified. We observed a dose-dependent association between lifetime alcohol intake and the risk of UADT cancer (multivariable-adjusted HR 2.67, 95 % CI 1.27-5.60 for an intake of ≥40 g/day and multivariable-adjusted HR 1.16, 95 % CI 1.06-1.28 for a 10 g/day increment in intake). A positive association with baseline alcohol intake (multivariable-adjusted HR 1.12, 95 % CI 1.02-1.24 for a 10 g/day increment in intake) was found to be a slightly weaker predictor of risk than lifetime intake.

CONCLUSIONS

Limiting alcohol intake from early adulthood may reduce UADT cancer risk.

Authors+Show Affiliations

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Level 3, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. harindra_jaya@yahoo.com.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Level 3, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Cancer Epidemiology Centre, Cancer Council Victoria, 615 St Kilda Rd, Melbourne, VIC, 3004, Australia.Cancer Epidemiology Centre, Cancer Council Victoria, 615 St Kilda Rd, Melbourne, VIC, 3004, Australia.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Level 3, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Cancer Epidemiology Centre, Cancer Council Victoria, 615 St Kilda Rd, Melbourne, VIC, 3004, Australia.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Level 3, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Cancer Epidemiology Centre, Cancer Council Victoria, 615 St Kilda Rd, Melbourne, VIC, 3004, Australia.Centre for Health and Society, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Centre for Alcohol Policy Research, Turning Point Alcohol and Drug Centre, 54-62 Gertrude Street, Melbourne, VIC, 3065, Australia. Centre for Social Research on Alcohol and Drugs, Stockholm University, 106 91, Stockholm, Sweden.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Level 3, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Cancer Epidemiology Centre, Cancer Council Victoria, 615 St Kilda Rd, Melbourne, VIC, 3004, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25403882

Citation

Jayasekara, Harindra, et al. "Lifetime Alcohol Consumption and Upper Aero-digestive Tract Cancer Risk in the Melbourne Collaborative Cohort Study." Cancer Causes & Control : CCC, vol. 26, no. 2, 2015, pp. 297-301.
Jayasekara H, MacInnis RJ, Hodge AM, et al. Lifetime alcohol consumption and upper aero-digestive tract cancer risk in the Melbourne Collaborative Cohort Study. Cancer Causes Control. 2015;26(2):297-301.
Jayasekara, H., MacInnis, R. J., Hodge, A. M., Hopper, J. L., Giles, G. G., Room, R., & English, D. R. (2015). Lifetime alcohol consumption and upper aero-digestive tract cancer risk in the Melbourne Collaborative Cohort Study. Cancer Causes & Control : CCC, 26(2), pp. 297-301. doi:10.1007/s10552-014-0495-y.
Jayasekara H, et al. Lifetime Alcohol Consumption and Upper Aero-digestive Tract Cancer Risk in the Melbourne Collaborative Cohort Study. Cancer Causes Control. 2015;26(2):297-301. PubMed PMID: 25403882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifetime alcohol consumption and upper aero-digestive tract cancer risk in the Melbourne Collaborative Cohort Study. AU - Jayasekara,Harindra, AU - MacInnis,Robert J, AU - Hodge,Allison M, AU - Hopper,John L, AU - Giles,Graham G, AU - Room,Robin, AU - English,Dallas R, Y1 - 2014/11/18/ PY - 2014/06/08/received PY - 2014/11/06/accepted PY - 2014/11/19/entrez PY - 2014/11/19/pubmed PY - 2016/3/30/medline SP - 297 EP - 301 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 26 IS - 2 N2 - PURPOSE: Cohort studies have rarely examined the association between upper aero-digestive tract (UADT) cancer risk and lifetime alcohol intake. We examined the associations between incident squamous cell carcinoma of the UADT (oral cavity, pharynx, larynx, and esophagus) and alcohol intake for different periods in life using data from the Melbourne Collaborative Cohort Study. METHODS: Usual alcohol intake for 10-year periods from age 20 was calculated using recalled frequency and quantity of beverage-specific consumption. Cox regression with age as the time axis was performed to estimate hazard ratios (HR) and 95 % confidence intervals (CI) for the associations of UADT cancer with alcohol intake for different periods in life compared with abstention. RESULTS: During a mean follow-up of 16.2 person-years, 98 incident cases of UADT cancer were identified. We observed a dose-dependent association between lifetime alcohol intake and the risk of UADT cancer (multivariable-adjusted HR 2.67, 95 % CI 1.27-5.60 for an intake of ≥40 g/day and multivariable-adjusted HR 1.16, 95 % CI 1.06-1.28 for a 10 g/day increment in intake). A positive association with baseline alcohol intake (multivariable-adjusted HR 1.12, 95 % CI 1.02-1.24 for a 10 g/day increment in intake) was found to be a slightly weaker predictor of risk than lifetime intake. CONCLUSIONS: Limiting alcohol intake from early adulthood may reduce UADT cancer risk. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/25403882/Lifetime_alcohol_consumption_and_upper_aero_digestive_tract_cancer_risk_in_the_Melbourne_Collaborative_Cohort_Study_ L2 - https://doi.org/10.1007/s10552-014-0495-y DB - PRIME DP - Unbound Medicine ER -