Tags

Type your tag names separated by a space and hit enter

Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway.
Mol Neurobiol 2016; 53(1):83-94MN

Abstract

β-asarone, a major component of Acorus tatarinowii Schott, has positive effects in neurodegeneration disease, however, its effect on the Parkinson's disease (PD) remains unclear. In this study, the effects of β-asarone on behavioral tests, neurotransmitters, tyrosine hydroxylase (TH), and α-synuclein (α-syn) were investigated in 6-hydroxydopamine (6-OHDA) induced rats. Furthermore, the JNK/Bcl-2/Beclin-1 autophagy pathway was also studied. The results showed that β-asarone improved the behavioral symptoms of rats in the open field, rotarod test, initiation time, and stepping time. And it increased the HVA, Dopacl, and 5-HIAA levels in striatum but not the DA and 5-HT levels. After administration of β-asarone, the TH level was elevated but the α-syn was declined in rats. It inhibited the expressions of LC3-II, but increased the p62 expression in SN4741 cells. Moreover, it affected the expressions of Beclin-1, Bcl-2, JNK, and p-JNK in vivo. We deduced that β-asarone may firstly downregulate expressions of JNK and p-JNK, and then indirectly increase the expression of Bcl-2. And the function of Beclin-1 could be inhibited, which could inhibit autophagy activation. Collectively, all data indicated that β-asarone may be explored as a potential therapeutic agent in PD therapy.

Authors+Show Affiliations

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. fangyq2@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25404088

Citation

Zhang, Sheng, et al. "Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism Via JNK/Bcl-2/Beclin-1 Pathway." Molecular Neurobiology, vol. 53, no. 1, 2016, pp. 83-94.
Zhang S, Gui XH, Huang LP, et al. Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway. Mol Neurobiol. 2016;53(1):83-94.
Zhang, S., Gui, X. H., Huang, L. P., Deng, M. Z., Fang, R. M., Ke, X. H., ... Fang, Y. Q. (2016). Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway. Molecular Neurobiology, 53(1), pp. 83-94. doi:10.1007/s12035-014-8950-z.
Zhang S, et al. Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism Via JNK/Bcl-2/Beclin-1 Pathway. Mol Neurobiol. 2016;53(1):83-94. PubMed PMID: 25404088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway. AU - Zhang,Sheng, AU - Gui,Xue-Hong, AU - Huang,Li-Ping, AU - Deng,Min-Zhen, AU - Fang,Ruo-Ming, AU - Ke,Xue-Hong, AU - He,Yu-Ping, AU - Li,Ling, AU - Fang,Yong-Qi, Y1 - 2014/11/18/ PY - 2014/07/05/received PY - 2014/10/20/accepted PY - 2014/11/19/entrez PY - 2014/11/19/pubmed PY - 2016/11/3/medline KW - Autophagy KW - Beclin-1 KW - JNK KW - Neuroprotection KW - Parkinson’s disease KW - β-asarone SP - 83 EP - 94 JF - Molecular neurobiology JO - Mol. Neurobiol. VL - 53 IS - 1 N2 - β-asarone, a major component of Acorus tatarinowii Schott, has positive effects in neurodegeneration disease, however, its effect on the Parkinson's disease (PD) remains unclear. In this study, the effects of β-asarone on behavioral tests, neurotransmitters, tyrosine hydroxylase (TH), and α-synuclein (α-syn) were investigated in 6-hydroxydopamine (6-OHDA) induced rats. Furthermore, the JNK/Bcl-2/Beclin-1 autophagy pathway was also studied. The results showed that β-asarone improved the behavioral symptoms of rats in the open field, rotarod test, initiation time, and stepping time. And it increased the HVA, Dopacl, and 5-HIAA levels in striatum but not the DA and 5-HT levels. After administration of β-asarone, the TH level was elevated but the α-syn was declined in rats. It inhibited the expressions of LC3-II, but increased the p62 expression in SN4741 cells. Moreover, it affected the expressions of Beclin-1, Bcl-2, JNK, and p-JNK in vivo. We deduced that β-asarone may firstly downregulate expressions of JNK and p-JNK, and then indirectly increase the expression of Bcl-2. And the function of Beclin-1 could be inhibited, which could inhibit autophagy activation. Collectively, all data indicated that β-asarone may be explored as a potential therapeutic agent in PD therapy. SN - 1559-1182 UR - https://www.unboundmedicine.com/medline/citation/25404088/Neuroprotective_Effects_of_β_Asarone_Against_6_Hydroxy_Dopamine_Induced_Parkinsonism_via_JNK/Bcl_2/Beclin_1_Pathway_ DB - PRIME DP - Unbound Medicine ER -