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Iron supplementation until 6 months protects marginally low-birth-weight infants from iron deficiency during their first year of life.
J Pediatr Gastroenterol Nutr 2015; 60(3):390-5JP

Abstract

OBJECTIVES

Low-birth-weight (LBW) infants (<2500 g) have an increased risk of iron deficiency (ID) during their first 6 months of life. The optimal dose and duration of iron supplementation to LBW infants are, however, unknown. The objective of the present study was to investigate the long-term effect on iron status and growth in marginally LBW (2000-2500 g) infants, of iron supplements given until 6 months of life.

METHODS

In a randomized controlled trial, 285 healthy marginally LBW infants received 0, 1, or 2 mg · kg(-1) · day(-1) of iron supplements from 6 weeks to 6 months of age. At 12 months and 3.5 years of life we measured length, weight, head circumference, and indicators of iron status (hemoglobin, ferritin, mean corpuscular volume, and transferrin saturation) and assessed the prevalence of iron depletion, functional ID, and ID anemia.

RESULTS

At 12 months of age, there was a significant difference in ferritin between the groups (P = 0.006). Furthermore, there was a significant difference in the prevalence of iron depletion (23.7%, 10.6%, and 6.8%, respectively, in the placebo, 1-mg, and 2-mg groups, P = 0.009) and similar nonsignificant trends for functional ID and ID anemia. At 3.5 years of life there were no significant differences in iron status and the mean prevalence of iron depletion was 3.2%. Anthropometric data were not affected by the intervention.

CONCLUSIONS

Iron supplements with 2 mg · kg(-1) · day(-1) until 6 months of life effectively reduces the risk of ID during the first 12 months of life and is an effective intervention for preventing early ID in marginally LBW infants.

Authors+Show Affiliations

*Department of Clinical Sciences, Pediatrics, Umeå University, Umeå †Department of Women and Child Health, Division of Neonatology, Karolinska Institute, Stockholm, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25406528

Citation

Berglund, Staffan K., et al. "Iron Supplementation Until 6 Months Protects Marginally Low-birth-weight Infants From Iron Deficiency During Their First Year of Life." Journal of Pediatric Gastroenterology and Nutrition, vol. 60, no. 3, 2015, pp. 390-5.
Berglund SK, Westrup B, Domellöf M. Iron supplementation until 6 months protects marginally low-birth-weight infants from iron deficiency during their first year of life. J Pediatr Gastroenterol Nutr. 2015;60(3):390-5.
Berglund, S. K., Westrup, B., & Domellöf, M. (2015). Iron supplementation until 6 months protects marginally low-birth-weight infants from iron deficiency during their first year of life. Journal of Pediatric Gastroenterology and Nutrition, 60(3), pp. 390-5. doi:10.1097/MPG.0000000000000633.
Berglund SK, Westrup B, Domellöf M. Iron Supplementation Until 6 Months Protects Marginally Low-birth-weight Infants From Iron Deficiency During Their First Year of Life. J Pediatr Gastroenterol Nutr. 2015;60(3):390-5. PubMed PMID: 25406528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron supplementation until 6 months protects marginally low-birth-weight infants from iron deficiency during their first year of life. AU - Berglund,Staffan K, AU - Westrup,Björn, AU - Domellöf,Magnus, PY - 2014/11/20/entrez PY - 2014/11/20/pubmed PY - 2016/5/18/medline SP - 390 EP - 5 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 60 IS - 3 N2 - OBJECTIVES: Low-birth-weight (LBW) infants (<2500 g) have an increased risk of iron deficiency (ID) during their first 6 months of life. The optimal dose and duration of iron supplementation to LBW infants are, however, unknown. The objective of the present study was to investigate the long-term effect on iron status and growth in marginally LBW (2000-2500 g) infants, of iron supplements given until 6 months of life. METHODS: In a randomized controlled trial, 285 healthy marginally LBW infants received 0, 1, or 2 mg · kg(-1) · day(-1) of iron supplements from 6 weeks to 6 months of age. At 12 months and 3.5 years of life we measured length, weight, head circumference, and indicators of iron status (hemoglobin, ferritin, mean corpuscular volume, and transferrin saturation) and assessed the prevalence of iron depletion, functional ID, and ID anemia. RESULTS: At 12 months of age, there was a significant difference in ferritin between the groups (P = 0.006). Furthermore, there was a significant difference in the prevalence of iron depletion (23.7%, 10.6%, and 6.8%, respectively, in the placebo, 1-mg, and 2-mg groups, P = 0.009) and similar nonsignificant trends for functional ID and ID anemia. At 3.5 years of life there were no significant differences in iron status and the mean prevalence of iron depletion was 3.2%. Anthropometric data were not affected by the intervention. CONCLUSIONS: Iron supplements with 2 mg · kg(-1) · day(-1) until 6 months of life effectively reduces the risk of ID during the first 12 months of life and is an effective intervention for preventing early ID in marginally LBW infants. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/25406528/Iron_supplementation_until_6_months_protects_marginally_low_birth_weight_infants_from_iron_deficiency_during_their_first_year_of_life_ L2 - http://Insights.ovid.com/pubmed?pmid=25406528 DB - PRIME DP - Unbound Medicine ER -