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Cardiovascular disease incidence, mortality and case fatality related to diabetes and metabolic syndrome: A community-based prospective study (Ansung-Ansan cohort 2001-12).
J Diabetes. 2015 Nov; 7(6):791-9.JD

Abstract

BACKGROUND

We evaluated the separate and combined effect of metabolic syndrome (MS) and diabetes on incident cardiovascular disease (CVD), CVD mortality and case fatality risk (CFR).

METHODS

8898 subjects were categorized into four groups on the basis of the presence of MS and diabetes (with MS, with diabetes, with both or without either). We compared the development of CVD events, mortality and CFR.

RESULTS

Over a mean follow-up of 8.0 years, 690 subjects developed CVD. There were 434 deaths, of which 101 were from CVD. The presence of diabetes alone, MS alone, or both was associated with an increased risk for incident CVD and CVD mortality. Compared with the MS only group, the adjusted hazard ratio (HR) for CVD events and CVD mortality in the diabetes only group was 1.07 (95% confidence interval [CI] 0.77-1.48) and 2.02 (95% CI 0.99-1.72), respectively. Among individuals with diabetes, the presence of MS did not significantly increase CVD risk and CVD mortality. The adjusted odds ratio for CVD CFR, including adjustment for the presence of MS, in subjects with diabetes versus without diabetes was 2.11 (95% CI 1.34-3.31).

CONCLUSIONS

There was no difference in the risk of incident CVD between individuals with diabetes alone and MS alone, whereas CVD mortality was much higher in individuals with diabetes only. The presence of MS did not exhibit an additive effect on CVD risk and mortality in individuals with diabetes. Individuals with diabetes had a higher CVD case fatality regardless of the presence of MS.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Changwon Hospital, Seoul, Republic of Korea.Department of Preventive Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Dong-A University Medical Center, Busan, Republic of Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25407754

Citation

Bae, Ji Cheol, et al. "Cardiovascular Disease Incidence, Mortality and Case Fatality Related to Diabetes and Metabolic Syndrome: a Community-based Prospective Study (Ansung-Ansan Cohort 2001-12)." Journal of Diabetes, vol. 7, no. 6, 2015, pp. 791-9.
Bae JC, Cho NH, Suh S, et al. Cardiovascular disease incidence, mortality and case fatality related to diabetes and metabolic syndrome: A community-based prospective study (Ansung-Ansan cohort 2001-12). J Diabetes. 2015;7(6):791-9.
Bae, J. C., Cho, N. H., Suh, S., Kim, J. H., Hur, K. Y., Jin, S. M., & Lee, M. K. (2015). Cardiovascular disease incidence, mortality and case fatality related to diabetes and metabolic syndrome: A community-based prospective study (Ansung-Ansan cohort 2001-12). Journal of Diabetes, 7(6), 791-9. https://doi.org/10.1111/1753-0407.12248
Bae JC, et al. Cardiovascular Disease Incidence, Mortality and Case Fatality Related to Diabetes and Metabolic Syndrome: a Community-based Prospective Study (Ansung-Ansan Cohort 2001-12). J Diabetes. 2015;7(6):791-9. PubMed PMID: 25407754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular disease incidence, mortality and case fatality related to diabetes and metabolic syndrome: A community-based prospective study (Ansung-Ansan cohort 2001-12). AU - Bae,Ji Cheol, AU - Cho,Nam H, AU - Suh,Sunghwan, AU - Kim,Jae Hyeon, AU - Hur,Kyu Yeon, AU - Jin,Sang-Man, AU - Lee,Moon-Kyu, Y1 - 2015/01/07/ PY - 2013/03/25/received PY - 2014/10/16/revised PY - 2014/11/02/accepted PY - 2014/11/20/entrez PY - 2014/11/20/pubmed PY - 2016/8/4/medline KW - cardiovascular disease KW - diabetes KW - metabolic syndrome KW - 关键词:心血管疾病,糖尿病,代谢综合征 SP - 791 EP - 9 JF - Journal of diabetes JO - J Diabetes VL - 7 IS - 6 N2 - BACKGROUND: We evaluated the separate and combined effect of metabolic syndrome (MS) and diabetes on incident cardiovascular disease (CVD), CVD mortality and case fatality risk (CFR). METHODS: 8898 subjects were categorized into four groups on the basis of the presence of MS and diabetes (with MS, with diabetes, with both or without either). We compared the development of CVD events, mortality and CFR. RESULTS: Over a mean follow-up of 8.0 years, 690 subjects developed CVD. There were 434 deaths, of which 101 were from CVD. The presence of diabetes alone, MS alone, or both was associated with an increased risk for incident CVD and CVD mortality. Compared with the MS only group, the adjusted hazard ratio (HR) for CVD events and CVD mortality in the diabetes only group was 1.07 (95% confidence interval [CI] 0.77-1.48) and 2.02 (95% CI 0.99-1.72), respectively. Among individuals with diabetes, the presence of MS did not significantly increase CVD risk and CVD mortality. The adjusted odds ratio for CVD CFR, including adjustment for the presence of MS, in subjects with diabetes versus without diabetes was 2.11 (95% CI 1.34-3.31). CONCLUSIONS: There was no difference in the risk of incident CVD between individuals with diabetes alone and MS alone, whereas CVD mortality was much higher in individuals with diabetes only. The presence of MS did not exhibit an additive effect on CVD risk and mortality in individuals with diabetes. Individuals with diabetes had a higher CVD case fatality regardless of the presence of MS. SN - 1753-0407 UR - https://www.unboundmedicine.com/medline/citation/25407754/Cardiovascular_disease_incidence_mortality_and_case_fatality_related_to_diabetes_and_metabolic_syndrome:_A_community_based_prospective_study__Ansung_Ansan_cohort_2001_12__ L2 - https://doi.org/10.1111/1753-0407.12248 DB - PRIME DP - Unbound Medicine ER -