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Wireless and simultaneous detections of multiple bio-molecules in a single sensor using Love wave biosensor.
Sensors (Basel). 2014 Nov 17; 14(11):21660-75.S

Abstract

A Love wave-based biosensor with a 440 MHz center frequency was developed for the simultaneous detection of two different analytes of Cartilage Oligomeric Matrix Protein (COMP) and rabbit immunoglobulin G (IgG) in a single sensor. The developed biosensor consists of one-port surface acoustic wave (SAW) reflective delay lines on a 41° YX LiNbO3 piezoelectric substrate, a poly(methyl methacrylate) (PMMA) waveguide layer, and two different sensitive films. The Love wave biosensor was wirelessly characterized using two antennas and a network analyzer. The binding of the analytes to the sensitive layers induced a large change in the time positions of the original reflection peaks mainly due to the mass loading effect. The assessed time shifts in the reflection peaks were matched well with the predicted values from coupling of mode (COM) modeling. The sensitivities evaluated from the sensitive films were ~15 deg/µg/mL for the rabbit IgG and ~1.8 deg/ng/mL for COMP.

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Authors+Show Affiliations

Oh H
Korea Electronics Technology Institute, Seongnam-si, Gyeonggi-do 463-816, Korea. ajounasa@gmail.com.
Fu C
Department of Electronics Engineering, Ajou University, Suwon, Gyeonggi-do 443-749, Korea. fuchen92@hotmail.com.
Kim K
Korea Electronics Technology Institute, Seongnam-si, Gyeonggi-do 463-816, Korea. kimkn@keti.re.kr.
Lee K
Department of Electronics Engineering, Ajou University, Suwon, Gyeonggi-do 443-749, Korea. keekeun@ajou.ac.kr.

MeSH

AcousticsAnimalsBiopolymersBiosensing TechniquesComplex MixturesComputer-Aided DesignEquipment DesignEquipment Failure AnalysisMicro-Electrical-Mechanical SystemsMiniaturizationRabbitsSoundTransducersWireless Technology

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25407905

Citation

Oh, Haekwan, et al. "Wireless and Simultaneous Detections of Multiple Bio-molecules in a Single Sensor Using Love Wave Biosensor." Sensors (Basel, Switzerland), vol. 14, no. 11, 2014, pp. 21660-75.
Oh H, Fu C, Kim K, et al. Wireless and simultaneous detections of multiple bio-molecules in a single sensor using Love wave biosensor. Sensors (Basel). 2014;14(11):21660-75.
Oh, H., Fu, C., Kim, K., & Lee, K. (2014). Wireless and simultaneous detections of multiple bio-molecules in a single sensor using Love wave biosensor. Sensors (Basel, Switzerland), 14(11), 21660-75. https://doi.org/10.3390/s141121660
Oh H, et al. Wireless and Simultaneous Detections of Multiple Bio-molecules in a Single Sensor Using Love Wave Biosensor. Sensors (Basel). 2014 Nov 17;14(11):21660-75. PubMed PMID: 25407905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wireless and simultaneous detections of multiple bio-molecules in a single sensor using Love wave biosensor. AU - Oh,Haekwan, AU - Fu,Chen, AU - Kim,Kunnyun, AU - Lee,Keekeun, Y1 - 2014/11/17/ PY - 2014/08/27/received PY - 2014/10/15/revised PY - 2014/10/24/accepted PY - 2014/11/20/entrez PY - 2014/11/20/pubmed PY - 2015/8/4/medline SP - 21660 EP - 75 JF - Sensors (Basel, Switzerland) JO - Sensors (Basel) VL - 14 IS - 11 N2 - A Love wave-based biosensor with a 440 MHz center frequency was developed for the simultaneous detection of two different analytes of Cartilage Oligomeric Matrix Protein (COMP) and rabbit immunoglobulin G (IgG) in a single sensor. The developed biosensor consists of one-port surface acoustic wave (SAW) reflective delay lines on a 41° YX LiNbO3 piezoelectric substrate, a poly(methyl methacrylate) (PMMA) waveguide layer, and two different sensitive films. The Love wave biosensor was wirelessly characterized using two antennas and a network analyzer. The binding of the analytes to the sensitive layers induced a large change in the time positions of the original reflection peaks mainly due to the mass loading effect. The assessed time shifts in the reflection peaks were matched well with the predicted values from coupling of mode (COM) modeling. The sensitivities evaluated from the sensitive films were ~15 deg/µg/mL for the rabbit IgG and ~1.8 deg/ng/mL for COMP. SN - 1424-8220 UR - https://www.unboundmedicine.com/medline/citation/25407905/Wireless_and_simultaneous_detections_of_multiple_bio_molecules_in_a_single_sensor_using_Love_wave_biosensor_ DB - PRIME DP - Unbound Medicine ER -