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Dietary fiber intake is inversely associated with stroke incidence in healthy Swedish adults.

Abstract

BACKGROUND

Prospective studies of dietary fiber intake in relation to stroke risk have reported inconsistent results.

OBJECTIVE

This study assessed the association between intake of total fiber and fiber sources and stroke incidence in healthy Swedish adults.

METHODS

The analysis was based on 69,677 participants (aged 45-83 y) from the Swedish Mammography Cohort and the Cohort of Swedish Men who were free from cancer, cardiovascular disease, and diabetes at baseline (1 January 1998). Diet was assessed with a food-frequency questionnaire. Cases of stroke were ascertained through linkage to the Swedish Inpatient Register and the Swedish Cause of Death Register. Cox proportional hazards regression model was used to calculate RRs, adjusted for potential confounders.

RESULTS

During 10.3 y of follow-up, 3680 incident stroke cases, including 2722 cerebral infarctions, 363 intracerebral hemorrhages, 160 subarachnoid hemorrhages, and 435 unspecified strokes, were ascertained. High intakes of total fiber and fiber from fruits and vegetables but not from cereals were inversely associated with risk of stroke. After adjustment for other risk factors for stroke, the multivariable RRs of total stroke for the highest vs. lowest quintile of intake were 0.90 (95% CI: 0.81, 0.99) for total fiber, 0.85 (95% CI: 0.77, 0.95) for fruit fiber, 0.90 (95% CI: 0.82, 1.00) for vegetable fiber, and 0.94 (95% CI: 0.84, 1.04) for cereal fiber.

CONCLUSION

These findings indicate that intake of dietary fiber, especially fruit and vegetable fibers, is inversely associated with risk of stroke.

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  • Authors+Show Affiliations

    ,

    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden susanna.larsson@ki.se.

    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

    Source

    The Journal of nutrition 144:12 2014 Dec pg 1952-5

    MeSH

    Aged
    Aged, 80 and over
    Cerebral Hemorrhage
    Cerebral Infarction
    Diet
    Dietary Fiber
    European Continental Ancestry Group
    Feeding Behavior
    Female
    Follow-Up Studies
    Fruit
    Humans
    Incidence
    Life Style
    Male
    Middle Aged
    Motor Activity
    Multivariate Analysis
    Nutrition Assessment
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Stroke
    Surveys and Questionnaires
    Sweden
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25411032

    Citation

    Larsson, Susanna C., and Alicja Wolk. "Dietary Fiber Intake Is Inversely Associated With Stroke Incidence in Healthy Swedish Adults." The Journal of Nutrition, vol. 144, no. 12, 2014, pp. 1952-5.
    Larsson SC, Wolk A. Dietary fiber intake is inversely associated with stroke incidence in healthy Swedish adults. J Nutr. 2014;144(12):1952-5.
    Larsson, S. C., & Wolk, A. (2014). Dietary fiber intake is inversely associated with stroke incidence in healthy Swedish adults. The Journal of Nutrition, 144(12), pp. 1952-5. doi:10.3945/jn.114.200634.
    Larsson SC, Wolk A. Dietary Fiber Intake Is Inversely Associated With Stroke Incidence in Healthy Swedish Adults. J Nutr. 2014;144(12):1952-5. PubMed PMID: 25411032.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fiber intake is inversely associated with stroke incidence in healthy Swedish adults. AU - Larsson,Susanna C, AU - Wolk,Alicja, Y1 - 2014/09/24/ PY - 2014/11/21/entrez PY - 2014/11/21/pubmed PY - 2015/2/18/medline KW - blood pressure KW - diet KW - dietary fiber KW - fruit KW - prospective study KW - stroke KW - vegetables SP - 1952 EP - 5 JF - The Journal of nutrition JO - J. Nutr. VL - 144 IS - 12 N2 - BACKGROUND: Prospective studies of dietary fiber intake in relation to stroke risk have reported inconsistent results. OBJECTIVE: This study assessed the association between intake of total fiber and fiber sources and stroke incidence in healthy Swedish adults. METHODS: The analysis was based on 69,677 participants (aged 45-83 y) from the Swedish Mammography Cohort and the Cohort of Swedish Men who were free from cancer, cardiovascular disease, and diabetes at baseline (1 January 1998). Diet was assessed with a food-frequency questionnaire. Cases of stroke were ascertained through linkage to the Swedish Inpatient Register and the Swedish Cause of Death Register. Cox proportional hazards regression model was used to calculate RRs, adjusted for potential confounders. RESULTS: During 10.3 y of follow-up, 3680 incident stroke cases, including 2722 cerebral infarctions, 363 intracerebral hemorrhages, 160 subarachnoid hemorrhages, and 435 unspecified strokes, were ascertained. High intakes of total fiber and fiber from fruits and vegetables but not from cereals were inversely associated with risk of stroke. After adjustment for other risk factors for stroke, the multivariable RRs of total stroke for the highest vs. lowest quintile of intake were 0.90 (95% CI: 0.81, 0.99) for total fiber, 0.85 (95% CI: 0.77, 0.95) for fruit fiber, 0.90 (95% CI: 0.82, 1.00) for vegetable fiber, and 0.94 (95% CI: 0.84, 1.04) for cereal fiber. CONCLUSION: These findings indicate that intake of dietary fiber, especially fruit and vegetable fibers, is inversely associated with risk of stroke. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/25411032/Dietary_fiber_intake_is_inversely_associated_with_stroke_incidence_in_healthy_Swedish_adults_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.114.200634 DB - PRIME DP - Unbound Medicine ER -