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Dietary flavonoid intake at midlife and healthy aging in women.
Am J Clin Nutr. 2014 Dec; 100(6):1489-97.AJ

Abstract

BACKGROUND

Dietary flavonoids have been related to lower risks of various chronic diseases, but it is unclear whether flavonoid intake in midlife helps to maintain good health and wellbeing in aging.

OBJECTIVE

We examined the relation of flavonoid intake in midlife with the prevalence of healthy aging.

DESIGN

We included 13,818 women from the Nurses' Health Study with dietary data and no major chronic diseases in 1984-1986 when they were aged in their late 50s (median age: 59 y); all women provided information on multiple aspects of aging an average of 15 y later. Intakes of 6 major flavonoid subclasses in midlife were ascertained on the basis of averaged intakes of flavonoid-rich foods from 2 food-frequency questionnaires (1984-1986). We defined healthy compared with usual aging as of age 70 y; healthy aging was based on survival to ≥70 y with maintenance of 4 health domains (no major chronic diseases or major impairments in cognitive or physical function or mental health).

RESULTS

Of women who survived until ≥70 y of age, 1517 women (11.0%) met our criteria for healthy aging. Compared with women in the lowest quintile of intake, women in the highest quintile of intake of several flavonoid subclasses at midlife had greater odds of healthy aging. After multivariable adjustment, ORs were as follows: flavones, 1.32 (95% CI: 1.10, 1.58); flavanone, 1.28 (95% CI: 1.08, 1.53); anthocyanin, 1.25 (95% CI: 1.04, 1.50); and flavonol, 1.18 (95% CI: 0.98, 1.42) (all P-trend ≤ 0.02). Consistently, greater intakes of major sources of these flavonoids (i.e., oranges, berries, onions, and apples) were associated with increased odds of healthy aging. We showed no association with flavan-3-ol monomers (P-trend = 0.80) or polymers (P-trend = 0.63).

CONCLUSION

Higher intake of flavonoids at midlife, specifically flavones, flavanones, anthocyanins, and flavonols, is associated with greater likelihood of health and wellbeing in individuals surviving to older ages.

Authors+Show Affiliations

From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (CS, QS, MKT, EBR, and FG); Institut National pour la Santé et la Recherche Médicale (INSERM), Centre INSERM U897-Epidémiologie-Biostatistiques and Université de Bordeaux, Bordeaux, France (CS); and the Departments of Epidemiology (EBR and FG) and Nutrition (QS and EBR), Harvard School of Public Health, Boston, MA.From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (CS, QS, MKT, EBR, and FG); Institut National pour la Santé et la Recherche Médicale (INSERM), Centre INSERM U897-Epidémiologie-Biostatistiques and Université de Bordeaux, Bordeaux, France (CS); and the Departments of Epidemiology (EBR and FG) and Nutrition (QS and EBR), Harvard School of Public Health, Boston, MA.From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (CS, QS, MKT, EBR, and FG); Institut National pour la Santé et la Recherche Médicale (INSERM), Centre INSERM U897-Epidémiologie-Biostatistiques and Université de Bordeaux, Bordeaux, France (CS); and the Departments of Epidemiology (EBR and FG) and Nutrition (QS and EBR), Harvard School of Public Health, Boston, MA.From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (CS, QS, MKT, EBR, and FG); Institut National pour la Santé et la Recherche Médicale (INSERM), Centre INSERM U897-Epidémiologie-Biostatistiques and Université de Bordeaux, Bordeaux, France (CS); and the Departments of Epidemiology (EBR and FG) and Nutrition (QS and EBR), Harvard School of Public Health, Boston, MA.From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (CS, QS, MKT, EBR, and FG); Institut National pour la Santé et la Recherche Médicale (INSERM), Centre INSERM U897-Epidémiologie-Biostatistiques and Université de Bordeaux, Bordeaux, France (CS); and the Departments of Epidemiology (EBR and FG) and Nutrition (QS and EBR), Harvard School of Public Health, Boston, MA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25411284

Citation

Samieri, Cécilia, et al. "Dietary Flavonoid Intake at Midlife and Healthy Aging in Women." The American Journal of Clinical Nutrition, vol. 100, no. 6, 2014, pp. 1489-97.
Samieri C, Sun Q, Townsend MK, et al. Dietary flavonoid intake at midlife and healthy aging in women. Am J Clin Nutr. 2014;100(6):1489-97.
Samieri, C., Sun, Q., Townsend, M. K., Rimm, E. B., & Grodstein, F. (2014). Dietary flavonoid intake at midlife and healthy aging in women. The American Journal of Clinical Nutrition, 100(6), 1489-97. https://doi.org/10.3945/ajcn.114.085605
Samieri C, et al. Dietary Flavonoid Intake at Midlife and Healthy Aging in Women. Am J Clin Nutr. 2014;100(6):1489-97. PubMed PMID: 25411284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary flavonoid intake at midlife and healthy aging in women. AU - Samieri,Cécilia, AU - Sun,Qi, AU - Townsend,Mary K, AU - Rimm,Eric B, AU - Grodstein,Francine, Y1 - 2014/10/29/ PY - 2014/11/21/entrez PY - 2014/11/21/pubmed PY - 2015/2/24/medline KW - cohort studies KW - flavonoid KW - healthy aging KW - public health KW - risk factors in epidemiology SP - 1489 EP - 97 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 100 IS - 6 N2 - BACKGROUND: Dietary flavonoids have been related to lower risks of various chronic diseases, but it is unclear whether flavonoid intake in midlife helps to maintain good health and wellbeing in aging. OBJECTIVE: We examined the relation of flavonoid intake in midlife with the prevalence of healthy aging. DESIGN: We included 13,818 women from the Nurses' Health Study with dietary data and no major chronic diseases in 1984-1986 when they were aged in their late 50s (median age: 59 y); all women provided information on multiple aspects of aging an average of 15 y later. Intakes of 6 major flavonoid subclasses in midlife were ascertained on the basis of averaged intakes of flavonoid-rich foods from 2 food-frequency questionnaires (1984-1986). We defined healthy compared with usual aging as of age 70 y; healthy aging was based on survival to ≥70 y with maintenance of 4 health domains (no major chronic diseases or major impairments in cognitive or physical function or mental health). RESULTS: Of women who survived until ≥70 y of age, 1517 women (11.0%) met our criteria for healthy aging. Compared with women in the lowest quintile of intake, women in the highest quintile of intake of several flavonoid subclasses at midlife had greater odds of healthy aging. After multivariable adjustment, ORs were as follows: flavones, 1.32 (95% CI: 1.10, 1.58); flavanone, 1.28 (95% CI: 1.08, 1.53); anthocyanin, 1.25 (95% CI: 1.04, 1.50); and flavonol, 1.18 (95% CI: 0.98, 1.42) (all P-trend ≤ 0.02). Consistently, greater intakes of major sources of these flavonoids (i.e., oranges, berries, onions, and apples) were associated with increased odds of healthy aging. We showed no association with flavan-3-ol monomers (P-trend = 0.80) or polymers (P-trend = 0.63). CONCLUSION: Higher intake of flavonoids at midlife, specifically flavones, flavanones, anthocyanins, and flavonols, is associated with greater likelihood of health and wellbeing in individuals surviving to older ages. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/25411284/Dietary_flavonoid_intake_at_midlife_and_healthy_aging_in_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.114.085605 DB - PRIME DP - Unbound Medicine ER -