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The gut microbiome and diet in psychiatry: focus on depression.
Curr Opin Psychiatry. 2015 Jan; 28(1):1-6.CO

Abstract

PURPOSE OF REVIEW

With depressive disorders the leading source of disability globally, the identification of new targets for prevention and management is imperative. A rapidly emerging field of research suggests that the microbiome-gut-brain axis is of substantial relevance to mood and behaviour. Similarly, unhealthy diet has recently emerged as a significant correlate of and risk factor for depression. This review provides evidence for the gut microbiota as a key factor mediating the link between diet and depressive illness.

RECENT FINDINGS

The development of new technologies is affording a better understanding of how diet influences gut microbiota composition and activity and how this may, in turn, influence depressive illness. New interventions are also suggesting the possible utility of pre and probiotic formulations and fermented food in influencing mental health.

SUMMARY

Although in its early stages, the emerging field of research focused on the human microbiome suggests an important role for the gut microbiota in influencing brain development, behaviour and mood in humans. The recognition that the gut microbiota interacts bidirectionally with other environmental risk factors, such as diet and stress, suggests promise in the development of interventions targeting the gut microbiota for the prevention and treatment of common mental health disorders.

Authors+Show Affiliations

aIMPACT Strategic Research Centre, Deakin University, Geelong bDepartment of Psychiatry cAlimentary Pharmabiotic Centre, University College Cork, Cork, Ireland dDepartment of Psychiatry, The University of Melbourne eThe Florey Institute of Neuroscience and Mental Health, At Genetics Lane, Royal, Parade, The University of Melbourne fOrygen Youth Health Research Centre, Parkville, Victoria gCentre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, Victoria hBlack Dog Institute, Sydney, New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25415497

Citation

Dash, Sarah, et al. "The Gut Microbiome and Diet in Psychiatry: Focus On Depression." Current Opinion in Psychiatry, vol. 28, no. 1, 2015, pp. 1-6.
Dash S, Clarke G, Berk M, et al. The gut microbiome and diet in psychiatry: focus on depression. Curr Opin Psychiatry. 2015;28(1):1-6.
Dash, S., Clarke, G., Berk, M., & Jacka, F. N. (2015). The gut microbiome and diet in psychiatry: focus on depression. Current Opinion in Psychiatry, 28(1), 1-6. https://doi.org/10.1097/YCO.0000000000000117
Dash S, et al. The Gut Microbiome and Diet in Psychiatry: Focus On Depression. Curr Opin Psychiatry. 2015;28(1):1-6. PubMed PMID: 25415497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The gut microbiome and diet in psychiatry: focus on depression. AU - Dash,Sarah, AU - Clarke,Gerard, AU - Berk,Michael, AU - Jacka,Felice N, PY - 2014/11/22/entrez PY - 2014/11/22/pubmed PY - 2015/7/15/medline SP - 1 EP - 6 JF - Current opinion in psychiatry JO - Curr Opin Psychiatry VL - 28 IS - 1 N2 - PURPOSE OF REVIEW: With depressive disorders the leading source of disability globally, the identification of new targets for prevention and management is imperative. A rapidly emerging field of research suggests that the microbiome-gut-brain axis is of substantial relevance to mood and behaviour. Similarly, unhealthy diet has recently emerged as a significant correlate of and risk factor for depression. This review provides evidence for the gut microbiota as a key factor mediating the link between diet and depressive illness. RECENT FINDINGS: The development of new technologies is affording a better understanding of how diet influences gut microbiota composition and activity and how this may, in turn, influence depressive illness. New interventions are also suggesting the possible utility of pre and probiotic formulations and fermented food in influencing mental health. SUMMARY: Although in its early stages, the emerging field of research focused on the human microbiome suggests an important role for the gut microbiota in influencing brain development, behaviour and mood in humans. The recognition that the gut microbiota interacts bidirectionally with other environmental risk factors, such as diet and stress, suggests promise in the development of interventions targeting the gut microbiota for the prevention and treatment of common mental health disorders. SN - 1473-6578 UR - https://www.unboundmedicine.com/medline/citation/25415497/The_gut_microbiome_and_diet_in_psychiatry:_focus_on_depression_ L2 - https://doi.org/10.1097/YCO.0000000000000117 DB - PRIME DP - Unbound Medicine ER -