TY - JOUR T1 - Palladium(II)-catalyzed oxidative dearomatization of free naphthols with two alkyne units. AU - Gu,Songlin, AU - Luo,Lei, AU - Liu,Jingjing, AU - Bai,Lu, AU - Zheng,Huayu, AU - Wang,Yaoyu, AU - Luan,Xinjun, Y1 - 2014/11/21/ PY - 2014/11/22/entrez PY - 2014/11/22/pubmed PY - 2014/11/22/medline SP - 6132 EP - 5 JF - Organic letters JO - Org Lett VL - 16 IS - 23 N2 - Readily available 2-naphthols undergo [2 + 2 + 1] spiroannulation reactions with alkynes in the presence of a Pd(II) catalyst and an oxidant. This process relies on C-H functionalization and naphthyl ring dearomatization at the 1-position of 2-naphthols to provide a variety of spirocyclic compounds. Using alkyl-aryl alkynes as the coupling partners led to regioisomeric mixtures in favor of the head-to-tail isomer bearing a quaternary carbon stereocenter. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/25415562/Palladium_II__catalyzed_oxidative_dearomatization_of_free_naphthols_with_two_alkyne_units_ DB - PRIME DP - Unbound Medicine ER -