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Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol.
Arch Gynecol Obstet 2015; 291(5):1181-6AG

Abstract

PURPOSE

To evaluate the effects of D-Chiro-Inositol in women affected by polycystic ovary syndrome (PCOS).

METHODS

We enrolled 48 patients, with homogeneous bio-physical characteristics, affected by PCOS and menstrual irregularities. These patients underwent treatment with 1 gr of D-Chiro-Inositol/die plus 400 mcg of Folic Acid/die orally for 6 months. We analyzed pre-treatment and post-treatment BMI, Systolic and Diastolic blood pressure, Ferriman-Gallwey score, Cremoncini score, serum LH, LH/FSH ratio, total and free testosterone, DHEA-S, Δ-4-androstenedione, SHBG, prolactin, glucose/IRI ratio, HOMA index, and resumption of regular menstrual cycles.

RESULTS

We evidenced a statistically significant reduction of systolic blood pressure, Ferriman-Gallwey score, LH, LH/FSH ratio, total Testosterone, free Testosterone, ∆-4-Androstenedione, Prolactin, and HOMA Index; in the same patients, we noticed a statistically significant increase of SHBG and Glycemia/IRI ratio. Moreover, we observed statistically significant (62.5%; p < 0.05) post-treatment menstrual cycle regularization.

CONCLUSIONS

D-Chiro-Inositol is effective in improving ovarian function and metabolism of patients affected by PCOS.

Authors+Show Affiliations

Department of Pediatric Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via C. Valeria 1, 98125, Messina, Italy, antlagana@unime.it.No affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Studies
Journal Article

Language

eng

PubMed ID

25416201

Citation

Laganà, Antonio Simone, et al. "Evaluation of Ovarian Function and Metabolic Factors in Women Affected By Polycystic Ovary Syndrome After Treatment With D-Chiro-Inositol." Archives of Gynecology and Obstetrics, vol. 291, no. 5, 2015, pp. 1181-6.
Laganà AS, Barbaro L, Pizzo A. Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol. Arch Gynecol Obstet. 2015;291(5):1181-6.
Laganà, A. S., Barbaro, L., & Pizzo, A. (2015). Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol. Archives of Gynecology and Obstetrics, 291(5), pp. 1181-6. doi:10.1007/s00404-014-3552-6.
Laganà AS, Barbaro L, Pizzo A. Evaluation of Ovarian Function and Metabolic Factors in Women Affected By Polycystic Ovary Syndrome After Treatment With D-Chiro-Inositol. Arch Gynecol Obstet. 2015;291(5):1181-6. PubMed PMID: 25416201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol. AU - Laganà,Antonio Simone, AU - Barbaro,Luisa, AU - Pizzo,Alfonsa, Y1 - 2014/11/22/ PY - 2014/07/20/received PY - 2014/11/11/accepted PY - 2014/11/23/entrez PY - 2014/11/25/pubmed PY - 2015/9/12/medline SP - 1181 EP - 6 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 291 IS - 5 N2 - PURPOSE: To evaluate the effects of D-Chiro-Inositol in women affected by polycystic ovary syndrome (PCOS). METHODS: We enrolled 48 patients, with homogeneous bio-physical characteristics, affected by PCOS and menstrual irregularities. These patients underwent treatment with 1 gr of D-Chiro-Inositol/die plus 400 mcg of Folic Acid/die orally for 6 months. We analyzed pre-treatment and post-treatment BMI, Systolic and Diastolic blood pressure, Ferriman-Gallwey score, Cremoncini score, serum LH, LH/FSH ratio, total and free testosterone, DHEA-S, Δ-4-androstenedione, SHBG, prolactin, glucose/IRI ratio, HOMA index, and resumption of regular menstrual cycles. RESULTS: We evidenced a statistically significant reduction of systolic blood pressure, Ferriman-Gallwey score, LH, LH/FSH ratio, total Testosterone, free Testosterone, ∆-4-Androstenedione, Prolactin, and HOMA Index; in the same patients, we noticed a statistically significant increase of SHBG and Glycemia/IRI ratio. Moreover, we observed statistically significant (62.5%; p < 0.05) post-treatment menstrual cycle regularization. CONCLUSIONS: D-Chiro-Inositol is effective in improving ovarian function and metabolism of patients affected by PCOS. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/25416201/Evaluation_of_ovarian_function_and_metabolic_factors_in_women_affected_by_polycystic_ovary_syndrome_after_treatment_with_D_Chiro_Inositol_ L2 - https://dx.doi.org/10.1007/s00404-014-3552-6 DB - PRIME DP - Unbound Medicine ER -