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Hyperandrogenism and phenotypes of polycystic ovary syndrome are not associated with differences in obstetric outcomes.
Acta Obstet Gynecol Scand 2015; 94(2):204-11AO

Abstract

OBJECTIVES

To investigate obstetric outcomes in Danish women with different phenotypes of polycystic ovary syndrome (PCOS) and isolated hyperandrogenism (HA) and describe the risk of adverse obstetric outcomes in women with PCOS and HA compared to controls.

DESIGN

Cohort study.

SETTING

Odense University Hospital, Denmark.

POPULATION

Women with PCOS were identified prospectively starting in 1997. Singleton pregnancies in women with PCOS and HA during 2003-2011 were included (n = 199). A control group was matched to the patient cohort according to date of childbirth (n = 995).

METHODS

Data on clinical characteristics and obstetric outcomes were collected in patients with PCOS and HA and controls. In PCOS and HA, total and free testosterone, sex hormone binding globulin, and hemoglobin A1c were measured outside pregnancy. During pregnancy, oral glucose tolerance tests were performed in 39 patients and 123 controls according to Danish national guidelines. PCOS phenotypes were based on the Rotterdam criteria.

MAIN OUTCOME MEASURES

Gestational diabetes mellitus, pregnancy-induced hypertension, preeclampsia, delivery by emergency cesarean section, preterm delivery and anthropometric measures in the newborn.

RESULTS

The incidence of adverse obstetric outcomes and anthropometric measures among the newborns were comparable between different phenotypes of PCOS and patients with HA. In the oral glucose tolerance test, patients had a higher risk of gestational diabetes mellitus compared with controls; the odds ratio (95% confidence interval) was 3.3 (1.5-6.9) after adjustment for age, parity, and body mass index (p = 0.002). The incidence of other adverse obstetric outcomes was similar in patients and controls.

CONCLUSIONS

Obstetric outcomes were comparable in women with different PCOS phenotypes.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25417943

Citation

Mumm, Hanne, et al. "Hyperandrogenism and Phenotypes of Polycystic Ovary Syndrome Are Not Associated With Differences in Obstetric Outcomes." Acta Obstetricia Et Gynecologica Scandinavica, vol. 94, no. 2, 2015, pp. 204-11.
Mumm H, Jensen DM, Sørensen JA, et al. Hyperandrogenism and phenotypes of polycystic ovary syndrome are not associated with differences in obstetric outcomes. Acta Obstet Gynecol Scand. 2015;94(2):204-11.
Mumm, H., Jensen, D. M., Sørensen, J. A., Andersen, L. L., Ravn, P., Andersen, M., & Glintborg, D. (2015). Hyperandrogenism and phenotypes of polycystic ovary syndrome are not associated with differences in obstetric outcomes. Acta Obstetricia Et Gynecologica Scandinavica, 94(2), pp. 204-11. doi:10.1111/aogs.12545.
Mumm H, et al. Hyperandrogenism and Phenotypes of Polycystic Ovary Syndrome Are Not Associated With Differences in Obstetric Outcomes. Acta Obstet Gynecol Scand. 2015;94(2):204-11. PubMed PMID: 25417943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperandrogenism and phenotypes of polycystic ovary syndrome are not associated with differences in obstetric outcomes. AU - Mumm,Hanne, AU - Jensen,Dorte Møller, AU - Sørensen,Jens Aage, AU - Andersen,Lise Lotte Torvin, AU - Ravn,Pernille, AU - Andersen,Marianne, AU - Glintborg,Dorte, Y1 - 2014/12/25/ PY - 2014/06/02/received PY - 2014/11/18/accepted PY - 2014/11/25/entrez PY - 2014/11/25/pubmed PY - 2015/3/21/medline KW - Polycystic ovary syndrome KW - gestational diabetes mellitus KW - hemoglobin A1c KW - hyperandrogenism KW - obstetric outcomes KW - polycystic ovary syndrome phenotypes KW - testosterone SP - 204 EP - 11 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 94 IS - 2 N2 - OBJECTIVES: To investigate obstetric outcomes in Danish women with different phenotypes of polycystic ovary syndrome (PCOS) and isolated hyperandrogenism (HA) and describe the risk of adverse obstetric outcomes in women with PCOS and HA compared to controls. DESIGN: Cohort study. SETTING: Odense University Hospital, Denmark. POPULATION: Women with PCOS were identified prospectively starting in 1997. Singleton pregnancies in women with PCOS and HA during 2003-2011 were included (n = 199). A control group was matched to the patient cohort according to date of childbirth (n = 995). METHODS: Data on clinical characteristics and obstetric outcomes were collected in patients with PCOS and HA and controls. In PCOS and HA, total and free testosterone, sex hormone binding globulin, and hemoglobin A1c were measured outside pregnancy. During pregnancy, oral glucose tolerance tests were performed in 39 patients and 123 controls according to Danish national guidelines. PCOS phenotypes were based on the Rotterdam criteria. MAIN OUTCOME MEASURES: Gestational diabetes mellitus, pregnancy-induced hypertension, preeclampsia, delivery by emergency cesarean section, preterm delivery and anthropometric measures in the newborn. RESULTS: The incidence of adverse obstetric outcomes and anthropometric measures among the newborns were comparable between different phenotypes of PCOS and patients with HA. In the oral glucose tolerance test, patients had a higher risk of gestational diabetes mellitus compared with controls; the odds ratio (95% confidence interval) was 3.3 (1.5-6.9) after adjustment for age, parity, and body mass index (p = 0.002). The incidence of other adverse obstetric outcomes was similar in patients and controls. CONCLUSIONS: Obstetric outcomes were comparable in women with different PCOS phenotypes. SN - 1600-0412 UR - https://www.unboundmedicine.com/medline/citation/25417943/Hyperandrogenism_and_phenotypes_of_polycystic_ovary_syndrome_are_not_associated_with_differences_in_obstetric_outcomes_ L2 - https://doi.org/10.1111/aogs.12545 DB - PRIME DP - Unbound Medicine ER -