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Indirect chiral separation of new recreational drugs by gas chromatography-mass spectrometry using trifluoroacetyl-L-prolyl chloride as chiral derivatization reagent.
Chirality. 2015 Mar; 27(3):211-5.C

Abstract

New recreational drugs such as amphetamine-, cathinone, and benzofury derivatives gained high popularity on the drug market in recent years. They can be purchased via the Internet from different providers and online portals. Most of these compounds are chiral, which makes the development of chiral separation methods necessary. Besides this, it is useful to find out if the compounds were sold as racemic mixtures. Also, it is important to check whether the new psychoactive compounds contain further ingredients or impurities. The aim of this research was the continuation of the application of a method for indirect chiral separation of 24 new psychoactive compounds recently purchased via the Internet. After derivatization with the chiral derivatization reagent trifluoroacetyl-L-prolyl chloride, chromatographic separation of diastereomers was achieved using a 30 m HP5-MS capillary column. As carrier gas, helium was used with a constant flow of 1.0 ml/min. Three different column temperature programs were tested. Under optimum conditions 13 out of 24 compounds were successfully resolved into their enantiomers obtaining Rs values up to 7.0. The use of a single quadrupole mass spectrometer as the detector allowed the identification of the compounds in multicomponent samples.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, Karl-Franzens University Graz, Graz, Austria.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25418781

Citation

Weiβ, Jennifer A., et al. "Indirect Chiral Separation of New Recreational Drugs By Gas Chromatography-mass Spectrometry Using trifluoroacetyl-L-prolyl Chloride as Chiral Derivatization Reagent." Chirality, vol. 27, no. 3, 2015, pp. 211-5.
Weiβ JA, Mohr S, Schmid MG. Indirect chiral separation of new recreational drugs by gas chromatography-mass spectrometry using trifluoroacetyl-L-prolyl chloride as chiral derivatization reagent. Chirality. 2015;27(3):211-5.
Weiβ, J. A., Mohr, S., & Schmid, M. G. (2015). Indirect chiral separation of new recreational drugs by gas chromatography-mass spectrometry using trifluoroacetyl-L-prolyl chloride as chiral derivatization reagent. Chirality, 27(3), 211-5. https://doi.org/10.1002/chir.22414
Weiβ JA, Mohr S, Schmid MG. Indirect Chiral Separation of New Recreational Drugs By Gas Chromatography-mass Spectrometry Using trifluoroacetyl-L-prolyl Chloride as Chiral Derivatization Reagent. Chirality. 2015;27(3):211-5. PubMed PMID: 25418781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indirect chiral separation of new recreational drugs by gas chromatography-mass spectrometry using trifluoroacetyl-L-prolyl chloride as chiral derivatization reagent. AU - Weiβ,Jennifer A, AU - Mohr,Stefan, AU - Schmid,Martin G, Y1 - 2014/11/22/ PY - 2014/09/08/received PY - 2014/10/10/accepted PY - 2014/11/25/entrez PY - 2014/11/25/pubmed PY - 2015/12/17/medline KW - L-TPC KW - amphetamines KW - cathinones KW - enantioseparation KW - legal highs SP - 211 EP - 5 JF - Chirality JO - Chirality VL - 27 IS - 3 N2 - New recreational drugs such as amphetamine-, cathinone, and benzofury derivatives gained high popularity on the drug market in recent years. They can be purchased via the Internet from different providers and online portals. Most of these compounds are chiral, which makes the development of chiral separation methods necessary. Besides this, it is useful to find out if the compounds were sold as racemic mixtures. Also, it is important to check whether the new psychoactive compounds contain further ingredients or impurities. The aim of this research was the continuation of the application of a method for indirect chiral separation of 24 new psychoactive compounds recently purchased via the Internet. After derivatization with the chiral derivatization reagent trifluoroacetyl-L-prolyl chloride, chromatographic separation of diastereomers was achieved using a 30 m HP5-MS capillary column. As carrier gas, helium was used with a constant flow of 1.0 ml/min. Three different column temperature programs were tested. Under optimum conditions 13 out of 24 compounds were successfully resolved into their enantiomers obtaining Rs values up to 7.0. The use of a single quadrupole mass spectrometer as the detector allowed the identification of the compounds in multicomponent samples. SN - 1520-636X UR - https://www.unboundmedicine.com/medline/citation/25418781/Indirect_chiral_separation_of_new_recreational_drugs_by_gas_chromatography-mass_spectrometry_using_trifluoroacetyl-L-prolyl_chloride_as_chiral_derivatization_reagent L2 - https://doi.org/10.1002/chir.22414 DB - PRIME DP - Unbound Medicine ER -