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Prognostic analysis of schistosomal rectal cancer.
Asian Pac J Cancer Prev. 2014; 15(21):9271-5.AP

Abstract

BACKGROUND

Schistosomiasis is an infectious disease that affects more than 230 million people worldwide, according to conservative estimates. Some studies published from China and Japan reported that schistosomiasis is a risk factor for colorectal cancer in Asia where the infective species is S. japonicum. However, there have been only few reports of prognosis of patients with schistosomal rectal cancer SRC.

OBJECTIVES

This study aimed to analyze differences in prognosis between SRC and non-schistosomal rectal cancer(NSRC) with current treatments.

MATERIALS AND METHODS

A retrospective review of 30 patients with schistosomal rectal cancer who underwent laparoscopic total mesorectal excision operation (TME) was performed. For each patient with schistosomal rectal cancer, a control group who underwent laparoscopic TME with non-schistosomal rectal cancer was matched for age, gender and tumor stage, resulting in 60 cases and controls.

RESULTS

Univariate analysis showed pathologic N stage (P=0.006) and pathologic TNM stage (P=0.047) statistically significantly correlated with disease-free survival (DFS). Pathologic N stage (P=0.014), pathologic TNM stage (P=0.002), and with/without schistosomiasis (P=0.026) were statistically significantly correlated with overall survival (OS). Schistosomiasis was the only independent prognostic factor for DFS and OS in multivariate analysis.

CONCLUSIONS

The prognosis of patients with schistosomal rectal cancer is poorer than with non-schistosomal rectal cancer.

Authors+Show Affiliations

Department of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, China E-mail : hxwangm@126.com.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25422211

Citation

Wang, Meng, et al. "Prognostic Analysis of Schistosomal Rectal Cancer." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 15, no. 21, 2014, pp. 9271-5.
Wang M, Zhang YC, Yang XY, et al. Prognostic analysis of schistosomal rectal cancer. Asian Pac J Cancer Prev. 2014;15(21):9271-5.
Wang, M., Zhang, Y. C., Yang, X. Y., & Wang, Z. Q. (2014). Prognostic analysis of schistosomal rectal cancer. Asian Pacific Journal of Cancer Prevention : APJCP, 15(21), 9271-5.
Wang M, et al. Prognostic Analysis of Schistosomal Rectal Cancer. Asian Pac J Cancer Prev. 2014;15(21):9271-5. PubMed PMID: 25422211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic analysis of schistosomal rectal cancer. AU - Wang,Meng, AU - Zhang,Yuan-Chuan, AU - Yang,Xu-Yang, AU - Wang,Zi-Qiang, PY - 2014/11/26/entrez PY - 2014/11/26/pubmed PY - 2015/7/16/medline SP - 9271 EP - 5 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 15 IS - 21 N2 - BACKGROUND: Schistosomiasis is an infectious disease that affects more than 230 million people worldwide, according to conservative estimates. Some studies published from China and Japan reported that schistosomiasis is a risk factor for colorectal cancer in Asia where the infective species is S. japonicum. However, there have been only few reports of prognosis of patients with schistosomal rectal cancer SRC. OBJECTIVES: This study aimed to analyze differences in prognosis between SRC and non-schistosomal rectal cancer(NSRC) with current treatments. MATERIALS AND METHODS: A retrospective review of 30 patients with schistosomal rectal cancer who underwent laparoscopic total mesorectal excision operation (TME) was performed. For each patient with schistosomal rectal cancer, a control group who underwent laparoscopic TME with non-schistosomal rectal cancer was matched for age, gender and tumor stage, resulting in 60 cases and controls. RESULTS: Univariate analysis showed pathologic N stage (P=0.006) and pathologic TNM stage (P=0.047) statistically significantly correlated with disease-free survival (DFS). Pathologic N stage (P=0.014), pathologic TNM stage (P=0.002), and with/without schistosomiasis (P=0.026) were statistically significantly correlated with overall survival (OS). Schistosomiasis was the only independent prognostic factor for DFS and OS in multivariate analysis. CONCLUSIONS: The prognosis of patients with schistosomal rectal cancer is poorer than with non-schistosomal rectal cancer. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/25422211/Prognostic_analysis_of_schistosomal_rectal_cancer_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:25422211&key=2014.15.21.9271 DB - PRIME DP - Unbound Medicine ER -