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[New Developments in CKD-MBD. Why is phosphate overload harmful?].
Clin Calcium. 2014 Dec; 24(12):1785-92.CC

Abstract

Phosphate restriction has been shown to improve clinical outcomes in patients with chronic kidney disease (CKD) . However, the molecular mechanism underlying the harm in phosphate overload remains unclear. Recent studies suggest that the true culprit of phosphate toxicity may not be phosphate per se but calciprotein particles (CPPs) , colloidal nanoparticles composed of calcium phosphate crystals and mineral binding proteins such as Fetuin-A. CPPs are highly bioactive ligands that induce cell damage and innate immune responses. Serum levels of CPPs are increased in CKD patients and independently associated with vascular calcification and chronic inflammation. CPPs may be viewed as a "pathogen" that plays an important role in the pathophysiology of CKD.

Authors+Show Affiliations

Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, Japan.

Pub Type(s)

Journal Article

Language

jpn

PubMed ID

25423923

Citation

Kuroo, Makoto. "[New Developments in CKD-MBD. Why Is Phosphate Overload Harmful?]." Clinical Calcium, vol. 24, no. 12, 2014, pp. 1785-92.
Kuroo M. [New Developments in CKD-MBD. Why is phosphate overload harmful?]. Clin Calcium. 2014;24(12):1785-92.
Kuroo, M. (2014). [New Developments in CKD-MBD. Why is phosphate overload harmful?]. Clinical Calcium, 24(12), 1785-92. https://doi.org/CliCa141217851792
Kuroo M. [New Developments in CKD-MBD. Why Is Phosphate Overload Harmful?]. Clin Calcium. 2014;24(12):1785-92. PubMed PMID: 25423923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [New Developments in CKD-MBD. Why is phosphate overload harmful?]. A1 - Kuroo,Makoto, PY - 2014/11/27/entrez PY - 2014/11/27/pubmed PY - 2016/12/15/medline SP - 1785 EP - 92 JF - Clinical calcium JO - Clin Calcium VL - 24 IS - 12 N2 - Phosphate restriction has been shown to improve clinical outcomes in patients with chronic kidney disease (CKD) . However, the molecular mechanism underlying the harm in phosphate overload remains unclear. Recent studies suggest that the true culprit of phosphate toxicity may not be phosphate per se but calciprotein particles (CPPs) , colloidal nanoparticles composed of calcium phosphate crystals and mineral binding proteins such as Fetuin-A. CPPs are highly bioactive ligands that induce cell damage and innate immune responses. Serum levels of CPPs are increased in CKD patients and independently associated with vascular calcification and chronic inflammation. CPPs may be viewed as a "pathogen" that plays an important role in the pathophysiology of CKD. SN - 0917-5857 UR - https://www.unboundmedicine.com/medline/citation/25423923/[New_Developments_in_CKD_MBD__Why_is_phosphate_overload_harmful]_ L2 - https://medlineplus.gov/chronickidneydisease.html DB - PRIME DP - Unbound Medicine ER -