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Effect of a low-fat diet enriched either with rapeseed oil or sunflower oil on plasma lipoproteins in children and adolescents with familial hypercholesterolaemia. Results of a pilot study.
Eur J Clin Nutr. 2015 Mar; 69(3):337-43.EJ

Abstract

BACKGROUND/OBJECTIVES

There is convincing evidence that unsaturated fatty acids exert favourable effects on plasma cholesterol levels. However, it is not clear which type of oil has the most pronounced effect, especially not in paediatric patients. The aim was to compare two low-fat diet regimes enriched with either monounsaturated fatty acids by rapeseed oil (RO) or polyunsaturated fatty acids by sunflower oil (SO) in children affected with familial hypercholesterolaemia (FH).

SUBJECTS/METHODS

Twenty-one children aged 6-18 years affected with FH were enrolled in this randomized and double-blind pilot trial. The subjects and their families were trained to adhere to a low-fat/low-cholesterol diet. All visible fats were to be replaced by either RO or SO (14-27 g/day) for 13 weeks. Dietary adherence was controlled by repeated 4-day dietary records; plasma lipids, lipoproteins and risk markers were assessed at baseline and post-intervention. Out of 21 subjects, 16 could be followed-up after 6 months.

RESULTS

Both fat-modified diets resulted in significant reduction in total cholesterol concentrations of 9.4% (RO P<0.005 vs SO P<0.05) and low-density lipoprotein (LDL) cholesterol concentrations of 12.7% (P<0.005) for RO and 11.3% (P<0.05) for SO. The reduction of the LDL/high-density lipoprotein (HDL) cholesterol ratio (RO 9% vs SO 3.5%) and high-sensitivity C-reactive protein (RO 16.8% vs SO 1.7%) were not statistically significant, respectively. In most participating families, a change in eating habits could be observed.

CONCLUSIONS

A fat-modified diet enriched with RO seems to have very similar effects on cholesterol levels as with SO. However, our study suggests that RO has possibly more favourable effects concerning cardiovascular risk profile. Both diets appear to be feasible and were well accepted among our subjects. Although these results are promising, larger trials will be required to validate our findings.

Authors+Show Affiliations

Division of Clinical Nutrition and Prevention, Department of Paediatrics and Adolescents Medicine, Vienna Medical University, Vienna, Austria.Department of Medical Statistics, Vienna Medical University, Vienna, Austria.Department of Medical Statistics, Vienna Medical University, Vienna, Austria.Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Vienna Medical University, Vienna, Austria.Department of Angiology, Vienna Medical University, Vienna, Austria.Austrian Academic Institute for Clinical Nutrition, Alserstraβe 14/4, Vienna, Austria.Division of Clinical Nutrition and Prevention, Department of Paediatrics and Adolescents Medicine, Vienna Medical University, Vienna, Austria.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25424602

Citation

Negele, L, et al. "Effect of a Low-fat Diet Enriched Either With Rapeseed Oil or Sunflower Oil On Plasma Lipoproteins in Children and Adolescents With Familial Hypercholesterolaemia. Results of a Pilot Study." European Journal of Clinical Nutrition, vol. 69, no. 3, 2015, pp. 337-43.
Negele L, Schneider B, Ristl R, et al. Effect of a low-fat diet enriched either with rapeseed oil or sunflower oil on plasma lipoproteins in children and adolescents with familial hypercholesterolaemia. Results of a pilot study. Eur J Clin Nutr. 2015;69(3):337-43.
Negele, L., Schneider, B., Ristl, R., Stulnig, T. M., Willfort-Ehringer, A., Helk, O., & Widhalm, K. (2015). Effect of a low-fat diet enriched either with rapeseed oil or sunflower oil on plasma lipoproteins in children and adolescents with familial hypercholesterolaemia. Results of a pilot study. European Journal of Clinical Nutrition, 69(3), 337-43. https://doi.org/10.1038/ejcn.2014.234
Negele L, et al. Effect of a Low-fat Diet Enriched Either With Rapeseed Oil or Sunflower Oil On Plasma Lipoproteins in Children and Adolescents With Familial Hypercholesterolaemia. Results of a Pilot Study. Eur J Clin Nutr. 2015;69(3):337-43. PubMed PMID: 25424602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a low-fat diet enriched either with rapeseed oil or sunflower oil on plasma lipoproteins in children and adolescents with familial hypercholesterolaemia. Results of a pilot study. AU - Negele,L, AU - Schneider,B, AU - Ristl,R, AU - Stulnig,T M, AU - Willfort-Ehringer,A, AU - Helk,O, AU - Widhalm,K, Y1 - 2014/11/26/ PY - 2014/03/24/received PY - 2014/08/30/revised PY - 2014/09/24/accepted PY - 2014/11/27/entrez PY - 2014/11/27/pubmed PY - 2015/11/13/medline SP - 337 EP - 43 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 69 IS - 3 N2 - BACKGROUND/OBJECTIVES: There is convincing evidence that unsaturated fatty acids exert favourable effects on plasma cholesterol levels. However, it is not clear which type of oil has the most pronounced effect, especially not in paediatric patients. The aim was to compare two low-fat diet regimes enriched with either monounsaturated fatty acids by rapeseed oil (RO) or polyunsaturated fatty acids by sunflower oil (SO) in children affected with familial hypercholesterolaemia (FH). SUBJECTS/METHODS: Twenty-one children aged 6-18 years affected with FH were enrolled in this randomized and double-blind pilot trial. The subjects and their families were trained to adhere to a low-fat/low-cholesterol diet. All visible fats were to be replaced by either RO or SO (14-27 g/day) for 13 weeks. Dietary adherence was controlled by repeated 4-day dietary records; plasma lipids, lipoproteins and risk markers were assessed at baseline and post-intervention. Out of 21 subjects, 16 could be followed-up after 6 months. RESULTS: Both fat-modified diets resulted in significant reduction in total cholesterol concentrations of 9.4% (RO P<0.005 vs SO P<0.05) and low-density lipoprotein (LDL) cholesterol concentrations of 12.7% (P<0.005) for RO and 11.3% (P<0.05) for SO. The reduction of the LDL/high-density lipoprotein (HDL) cholesterol ratio (RO 9% vs SO 3.5%) and high-sensitivity C-reactive protein (RO 16.8% vs SO 1.7%) were not statistically significant, respectively. In most participating families, a change in eating habits could be observed. CONCLUSIONS: A fat-modified diet enriched with RO seems to have very similar effects on cholesterol levels as with SO. However, our study suggests that RO has possibly more favourable effects concerning cardiovascular risk profile. Both diets appear to be feasible and were well accepted among our subjects. Although these results are promising, larger trials will be required to validate our findings. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/25424602/Effect_of_a_low_fat_diet_enriched_either_with_rapeseed_oil_or_sunflower_oil_on_plasma_lipoproteins_in_children_and_adolescents_with_familial_hypercholesterolaemia__Results_of_a_pilot_study_ L2 - https://doi.org/10.1038/ejcn.2014.234 DB - PRIME DP - Unbound Medicine ER -