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Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents.
J Pharmacol Exp Ther. 1989 May; 249(2):444-9.JP

Abstract

Marijuana has been reported to be an effective antinauseant and antiemetic in patients receiving cancer chemotherapy. Whether this is due to psychological changes, central antiemetic properties and/or direct effects on gastrointestinal (GI) function is not known. The purpose of these investigations was to determine whether the major constituents of marijuana and the synthetic cannabinoid nabilone have any effects on GI function which can be detected in rodent models of GI transit and motility. Intravenous delta 9-tetrahydrocannabinol (delta 9-THC) slowed the rate of gastric emptying and small intestinal transit in mice and in rats. Delta 9,11-THC, cannabinol and nabilone given i.v. also inhibited small intestinal transit in mice, but were less effective in reducing gastric emptying. Cannabidiol given i.v. had no effect on gastric emptying or intestinal transit. Those cannabinoids which inhibited GI transit did so at doses equal to, or lower, than those reported to produce central nervous system activity. In rats, delta 9-THC produced greater inhibition of gastric emptying and small intestinal transit than large bowel transit, indicating a selectivity for the more proximal sections of the gut. In addition, i.v. delta 9-THC decreased the frequency of both gastric and intestinal contractions without altering intraluminal pressure. Such changes probably reflect a decrease in propulsive activity, without change in basal tone. These data indicate that delta 9-THC, delta 9,11-THC, cannabinol and nabilone (but not cannabidiol) exert an inhibitory effect on GI transit and motility in rats.

Authors+Show Affiliations

Department of Pharmacology, University of Arizona, Tucson.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2542532

Citation

Shook, J E., and T F. Burks. "Psychoactive Cannabinoids Reduce Gastrointestinal Propulsion and Motility in Rodents." The Journal of Pharmacology and Experimental Therapeutics, vol. 249, no. 2, 1989, pp. 444-9.
Shook JE, Burks TF. Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents. J Pharmacol Exp Ther. 1989;249(2):444-9.
Shook, J. E., & Burks, T. F. (1989). Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents. The Journal of Pharmacology and Experimental Therapeutics, 249(2), 444-9.
Shook JE, Burks TF. Psychoactive Cannabinoids Reduce Gastrointestinal Propulsion and Motility in Rodents. J Pharmacol Exp Ther. 1989;249(2):444-9. PubMed PMID: 2542532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents. AU - Shook,J E, AU - Burks,T F, PY - 1989/5/1/pubmed PY - 1989/5/1/medline PY - 1989/5/1/entrez SP - 444 EP - 9 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 249 IS - 2 N2 - Marijuana has been reported to be an effective antinauseant and antiemetic in patients receiving cancer chemotherapy. Whether this is due to psychological changes, central antiemetic properties and/or direct effects on gastrointestinal (GI) function is not known. The purpose of these investigations was to determine whether the major constituents of marijuana and the synthetic cannabinoid nabilone have any effects on GI function which can be detected in rodent models of GI transit and motility. Intravenous delta 9-tetrahydrocannabinol (delta 9-THC) slowed the rate of gastric emptying and small intestinal transit in mice and in rats. Delta 9,11-THC, cannabinol and nabilone given i.v. also inhibited small intestinal transit in mice, but were less effective in reducing gastric emptying. Cannabidiol given i.v. had no effect on gastric emptying or intestinal transit. Those cannabinoids which inhibited GI transit did so at doses equal to, or lower, than those reported to produce central nervous system activity. In rats, delta 9-THC produced greater inhibition of gastric emptying and small intestinal transit than large bowel transit, indicating a selectivity for the more proximal sections of the gut. In addition, i.v. delta 9-THC decreased the frequency of both gastric and intestinal contractions without altering intraluminal pressure. Such changes probably reflect a decrease in propulsive activity, without change in basal tone. These data indicate that delta 9-THC, delta 9,11-THC, cannabinol and nabilone (but not cannabidiol) exert an inhibitory effect on GI transit and motility in rats. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/2542532/Psychoactive_cannabinoids_reduce_gastrointestinal_propulsion_and_motility_in_rodents_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2542532 DB - PRIME DP - Unbound Medicine ER -