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The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease.
Neuropathol Appl Neurobiol. 1989 Jan-Feb; 15(1):27-44.NA

Abstract

A retrospective study of 269 patients with a clinical diagnosis of Parkinson's syndrome was carried out. Seventy-eight were selected as cases of Parkinson's disease on the basis of generally accepted criteria. Of these, 73 were found to have Lewy bodies and cell loss in the substantia nigra, two had the pathological changes of striatonigral degeneration, two had extensive neurofibrillary tangles and nigral cell loss compatible with post-encephalitic parkinsonian syndrome, and one had Lewy bodies and striatonigral degeneration. Pathological examination of the remaining brains revealed Lewy bodies with cell loss in the nigra, a different pathological diagnosis, or normal basal ganglia. No unclassifiable 'senile' patients, or cases with neurofibrillary tangle degeneration or extranigral pathology of unknown cause were found. As a result of these findings clinico-pathological diagnostic criteria for Parkinson's disease are proposed. All patients with this diagnosis had Lewy bodies in surviving neurons of two unilateral 7 microns sections of the mid-part of the substantia nigra. The frequency of Lewy bodies in multiple system atrophy, Steele-Richardson-Olszewski syndrome and Alzheimer's disease was low and similar to that in age-matched 'normal' controls. Pathological findings were compatible with the notion that these individuals have preclinical or coincidental Parkinson's disease.

Authors+Show Affiliations

Department of Neuropathology, National Hospitals for Nervous Diseases, London.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2542825

Citation

Gibb, W R., and A J. Lees. "The Significance of the Lewy Body in the Diagnosis of Idiopathic Parkinson's Disease." Neuropathology and Applied Neurobiology, vol. 15, no. 1, 1989, pp. 27-44.
Gibb WR, Lees AJ. The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease. Neuropathol Appl Neurobiol. 1989;15(1):27-44.
Gibb, W. R., & Lees, A. J. (1989). The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease. Neuropathology and Applied Neurobiology, 15(1), 27-44.
Gibb WR, Lees AJ. The Significance of the Lewy Body in the Diagnosis of Idiopathic Parkinson's Disease. Neuropathol Appl Neurobiol. 1989 Jan-Feb;15(1):27-44. PubMed PMID: 2542825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease. AU - Gibb,W R, AU - Lees,A J, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 27 EP - 44 JF - Neuropathology and applied neurobiology JO - Neuropathol Appl Neurobiol VL - 15 IS - 1 N2 - A retrospective study of 269 patients with a clinical diagnosis of Parkinson's syndrome was carried out. Seventy-eight were selected as cases of Parkinson's disease on the basis of generally accepted criteria. Of these, 73 were found to have Lewy bodies and cell loss in the substantia nigra, two had the pathological changes of striatonigral degeneration, two had extensive neurofibrillary tangles and nigral cell loss compatible with post-encephalitic parkinsonian syndrome, and one had Lewy bodies and striatonigral degeneration. Pathological examination of the remaining brains revealed Lewy bodies with cell loss in the nigra, a different pathological diagnosis, or normal basal ganglia. No unclassifiable 'senile' patients, or cases with neurofibrillary tangle degeneration or extranigral pathology of unknown cause were found. As a result of these findings clinico-pathological diagnostic criteria for Parkinson's disease are proposed. All patients with this diagnosis had Lewy bodies in surviving neurons of two unilateral 7 microns sections of the mid-part of the substantia nigra. The frequency of Lewy bodies in multiple system atrophy, Steele-Richardson-Olszewski syndrome and Alzheimer's disease was low and similar to that in age-matched 'normal' controls. Pathological findings were compatible with the notion that these individuals have preclinical or coincidental Parkinson's disease. SN - 0305-1846 UR - https://www.unboundmedicine.com/medline/citation/2542825/The_significance_of_the_Lewy_body_in_the_diagnosis_of_idiopathic_Parkinson's_disease_ L2 - https://doi.org/10.1111/j.1365-2990.1989.tb01147.x DB - PRIME DP - Unbound Medicine ER -