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Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease.
J Alzheimers Dis. 2015; 45(1):45-56.JA

Abstract

BACKGROUND

Alzheimer's disease (AD) is a neurodegenerative disorder with emerging evidence that it is associated with retinal ganglion cell loss; however, few data exist to establish this association.

OBJECTIVE

To determine whether macular ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL), as quantitatively measured by non-invasive in vivo spectral-domain optical coherence tomography (SD-OCT), are altered in patients with AD and mild cognitive impairment (MCI).

METHODS

Patients with AD and MCI were recruited from dementia/memory clinics, and cognitively normal controls were selected from the Singapore Epidemiology of Eye Disease program. SD-OCT (Cirrus HD-OCT, software version 6.0.2, Carl Zeiss Meditec Inc, Dublin, CA) was used to measure the GC-IPL and RNFL thicknesses.

RESULTS

Compared with cognitively normal controls (n = 123), patients with AD (n = 100) had significantly reduced GC-IPL thicknesses in all six (superior, superonasal, inferonasal, inferior, inferotemporal, and superotemporal) sectors (mean differences from -3.42 to -4.99 μm, all p < 0.05) and reduced RNFL thickness in superior quadrant (-6.04 μm, p = 0.039). Patients with MCI (n = 41) also had significantly reduced GC-IPL thicknesses compared with controls (mean differences from -3.62 to -5.83 μm, all p < 0.05). Area under receiver operating characteristic curves of GC-IPL were generally higher than that of RNFL to discriminate AD and MCI from the controls.

CONCLUSIONS

Our data strengthens the link between retinal ganglion cell neuronal and optic nerve axonal loss with AD, and suggest that assessment of macular GC-IPL can be a test to detect neuronal injury in early AD and MCI.

Authors+Show Affiliations

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Memory Aging and Cognition Centre, National University Health System, Singapore Department of Pharmacology, National University of Singapore, Singapore.Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore Memory Aging and Cognition Centre, National University Health System, Singapore.Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.Memory Aging and Cognition Centre, National University Health System, Singapore.Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore.Department of Geriatric Medicine, Singapore General Hospital, Singapore.Memory Aging and Cognition Centre, National University Health System, Singapore Department of Pharmacology, National University of Singapore, Singapore.Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25428254

Citation

Cheung, Carol Yim-lui, et al. "Retinal Ganglion Cell Analysis Using High-definition Optical Coherence Tomography in Patients With Mild Cognitive Impairment and Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 45, no. 1, 2015, pp. 45-56.
Cheung CY, Ong YT, Hilal S, et al. Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2015;45(1):45-56.
Cheung, C. Y., Ong, Y. T., Hilal, S., Ikram, M. K., Low, S., Ong, Y. L., Venketasubramanian, N., Yap, P., Seow, D., Chen, C. L., & Wong, T. Y. (2015). Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease : JAD, 45(1), 45-56. https://doi.org/10.3233/JAD-141659
Cheung CY, et al. Retinal Ganglion Cell Analysis Using High-definition Optical Coherence Tomography in Patients With Mild Cognitive Impairment and Alzheimer's Disease. J Alzheimers Dis. 2015;45(1):45-56. PubMed PMID: 25428254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease. AU - Cheung,Carol Yim-lui, AU - Ong,Yi Ting, AU - Hilal,Saima, AU - Ikram,M Kamran, AU - Low,Sally, AU - Ong,Yi Lin, AU - Venketasubramanian,N, AU - Yap,Philip, AU - Seow,Dennis, AU - Chen,Christopher Li Hsian, AU - Wong,Tien Yin, PY - 2014/11/28/entrez PY - 2014/11/28/pubmed PY - 2016/3/2/medline KW - Alzheimer's disease KW - mild cognitive impairment KW - neurodegenerative disorder KW - optic nerve KW - retinal ganglion cell KW - spectral-domain optical coherence tomography SP - 45 EP - 56 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 45 IS - 1 N2 - BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder with emerging evidence that it is associated with retinal ganglion cell loss; however, few data exist to establish this association. OBJECTIVE: To determine whether macular ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL), as quantitatively measured by non-invasive in vivo spectral-domain optical coherence tomography (SD-OCT), are altered in patients with AD and mild cognitive impairment (MCI). METHODS: Patients with AD and MCI were recruited from dementia/memory clinics, and cognitively normal controls were selected from the Singapore Epidemiology of Eye Disease program. SD-OCT (Cirrus HD-OCT, software version 6.0.2, Carl Zeiss Meditec Inc, Dublin, CA) was used to measure the GC-IPL and RNFL thicknesses. RESULTS: Compared with cognitively normal controls (n = 123), patients with AD (n = 100) had significantly reduced GC-IPL thicknesses in all six (superior, superonasal, inferonasal, inferior, inferotemporal, and superotemporal) sectors (mean differences from -3.42 to -4.99 μm, all p < 0.05) and reduced RNFL thickness in superior quadrant (-6.04 μm, p = 0.039). Patients with MCI (n = 41) also had significantly reduced GC-IPL thicknesses compared with controls (mean differences from -3.62 to -5.83 μm, all p < 0.05). Area under receiver operating characteristic curves of GC-IPL were generally higher than that of RNFL to discriminate AD and MCI from the controls. CONCLUSIONS: Our data strengthens the link between retinal ganglion cell neuronal and optic nerve axonal loss with AD, and suggest that assessment of macular GC-IPL can be a test to detect neuronal injury in early AD and MCI. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25428254/Retinal_ganglion_cell_analysis_using_high_definition_optical_coherence_tomography_in_patients_with_mild_cognitive_impairment_and_Alzheimer's_disease_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JAD-141659 DB - PRIME DP - Unbound Medicine ER -