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Treatment of 308-nm excimer laser on vitiligo: A systemic review of randomized controlled trials.
J Dermatolog Treat. 2015; 26(4):347-53.JD

Abstract

BACKGROUND

Vitiligo is an acquired cutaneous hypopigmentary disorder, which characterized by solitary or multiple depigmented maculae or patches. The 308-nm excimer laser has been used as phototherapy on vitiligo.

OBJECTIVE

To evaluate the efficacy and safety of 308-nm excimer laser on vitiligo.

METHODS

Randomized controlled trials were searched to conduct a systematic review. The keywords were identified as laser/excimer laser/quasimolecule/XeCl" and "vitiligo".

RESULTS

Seven studies with 390 vitiligo patients were included. No significant differences were seen between 308-nm excimer laser and 308-nm excimer lamp on either ≥75% or ≥50% re-pigmentation rate, or between 308-nm excimer laser and narrowband-ultraviolet B (NB-UVB) on either 100% or ≥75% re-pigmentation rate. More patients or lesions achieved ≥50% re-pigmentation rate by 308-nm excimer laser treatment than by NB-UVB treatment. The side effects of 308-nm excimer laser were slight and tolerable.

CONCLUSIONS

The 308-nm excimer laser showed equivalent efficacies to 308-nm excimer lamp control and NB-UVB control concerning ≥75% re-pigmentation rate of vitiligo patches. More studies with high methodological quality, low risk of bias and more sample size are needed to confirm the conclusion.

Authors+Show Affiliations

Department of Dermatology, No. 1 Hospital of China Medical University , Shenyang , China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25428573

Citation

Sun, Yan, et al. "Treatment of 308-nm Excimer Laser On Vitiligo: a Systemic Review of Randomized Controlled Trials." The Journal of Dermatological Treatment, vol. 26, no. 4, 2015, pp. 347-53.
Sun Y, Wu Y, Xiao B, et al. Treatment of 308-nm excimer laser on vitiligo: A systemic review of randomized controlled trials. J Dermatolog Treat. 2015;26(4):347-53.
Sun, Y., Wu, Y., Xiao, B., Li, L., Li, L., Chen, H. D., & Gao, X. H. (2015). Treatment of 308-nm excimer laser on vitiligo: A systemic review of randomized controlled trials. The Journal of Dermatological Treatment, 26(4), 347-53. https://doi.org/10.3109/09546634.2014.991268
Sun Y, et al. Treatment of 308-nm Excimer Laser On Vitiligo: a Systemic Review of Randomized Controlled Trials. J Dermatolog Treat. 2015;26(4):347-53. PubMed PMID: 25428573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of 308-nm excimer laser on vitiligo: A systemic review of randomized controlled trials. AU - Sun,Yan, AU - Wu,Yan, AU - Xiao,Bihuan, AU - Li,Lu, AU - Li,Li, AU - Chen,Hong-Duo, AU - Gao,Xing-Hua, Y1 - 2015/01/30/ PY - 2014/11/28/entrez PY - 2014/11/28/pubmed PY - 2016/2/19/medline KW - 308-nm excimer laser KW - randomized controlled trials KW - systemic review KW - vitiligo SP - 347 EP - 53 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 26 IS - 4 N2 - BACKGROUND: Vitiligo is an acquired cutaneous hypopigmentary disorder, which characterized by solitary or multiple depigmented maculae or patches. The 308-nm excimer laser has been used as phototherapy on vitiligo. OBJECTIVE: To evaluate the efficacy and safety of 308-nm excimer laser on vitiligo. METHODS: Randomized controlled trials were searched to conduct a systematic review. The keywords were identified as laser/excimer laser/quasimolecule/XeCl" and "vitiligo". RESULTS: Seven studies with 390 vitiligo patients were included. No significant differences were seen between 308-nm excimer laser and 308-nm excimer lamp on either ≥75% or ≥50% re-pigmentation rate, or between 308-nm excimer laser and narrowband-ultraviolet B (NB-UVB) on either 100% or ≥75% re-pigmentation rate. More patients or lesions achieved ≥50% re-pigmentation rate by 308-nm excimer laser treatment than by NB-UVB treatment. The side effects of 308-nm excimer laser were slight and tolerable. CONCLUSIONS: The 308-nm excimer laser showed equivalent efficacies to 308-nm excimer lamp control and NB-UVB control concerning ≥75% re-pigmentation rate of vitiligo patches. More studies with high methodological quality, low risk of bias and more sample size are needed to confirm the conclusion. SN - 1471-1753 UR - https://www.unboundmedicine.com/medline/citation/25428573/Treatment_of_308_nm_excimer_laser_on_vitiligo:_A_systemic_review_of_randomized_controlled_trials_ L2 - http://www.tandfonline.com/doi/full/10.3109/09546634.2014.991268 DB - PRIME DP - Unbound Medicine ER -