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Insect trehalase: physiological significance and potential applications.
Glycobiology 2015; 25(4):357-67G

Abstract

Trehalose, a non-reducing disaccharide, is widespread throughout the biological world. It is the major blood sugar in insects playing a crucial role as an instant source of energy and in dealing with abiotic stresses. The hydrolysis of trehalose is under the enzymatic control of trehalase. The enzyme trehalase is gaining interest in insect physiology as it regulates energy metabolism and glucose generation via trehalose catabolism. The two forms of insect trehalase namely, Tre-1 and Tre-2, are important in energy supply, growth, metamorphosis, stress recovery, chitin synthesis and insect flight. Insect trehalase has not been reviewed in depth and the information available is quite scattered. The present mini review discusses our recent understanding of the regulation, mechanism and biochemical characterization of insect trehalase with respect to its physiological role in vital life functions. We also highlight the molecular and biochemical properties of insect trehalase that makes it amenable to competitive inhibition by most glycosidase inhibitors. Due to its crucial role in carbon metabolism in insects, application of inhibitors against trehalose can form a promising area towards formulating strategies for insect pest control.

Authors+Show Affiliations

Division of Biochemical Sciences, CSIR National Chemical Laboratory, Pune 411008, India.Centre for Advanced Studies, Department of Zoology, Savitribai Phule Pune University, Pune 411007, India.Centre for Advanced Studies, Department of Zoology, Savitribai Phule Pune University, Pune 411007, India.Division of Biochemical Sciences, CSIR National Chemical Laboratory, Pune 411008, India sm.gaikwad@ncl.res.in.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25429048

Citation

Shukla, Ekta, et al. "Insect Trehalase: Physiological Significance and Potential Applications." Glycobiology, vol. 25, no. 4, 2015, pp. 357-67.
Shukla E, Thorat LJ, Nath BB, et al. Insect trehalase: physiological significance and potential applications. Glycobiology. 2015;25(4):357-67.
Shukla, E., Thorat, L. J., Nath, B. B., & Gaikwad, S. M. (2015). Insect trehalase: physiological significance and potential applications. Glycobiology, 25(4), pp. 357-67. doi:10.1093/glycob/cwu125.
Shukla E, et al. Insect Trehalase: Physiological Significance and Potential Applications. Glycobiology. 2015;25(4):357-67. PubMed PMID: 25429048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insect trehalase: physiological significance and potential applications. AU - Shukla,Ekta, AU - Thorat,Leena J, AU - Nath,Bimalendu B, AU - Gaikwad,Sushama M, Y1 - 2014/11/26/ PY - 2014/11/28/entrez PY - 2014/11/28/pubmed PY - 2015/12/15/medline KW - carbohydrate metabolism KW - glycosidase inhibitor KW - glycoside hydrolase KW - trehalase KW - trehalose SP - 357 EP - 67 JF - Glycobiology JO - Glycobiology VL - 25 IS - 4 N2 - Trehalose, a non-reducing disaccharide, is widespread throughout the biological world. It is the major blood sugar in insects playing a crucial role as an instant source of energy and in dealing with abiotic stresses. The hydrolysis of trehalose is under the enzymatic control of trehalase. The enzyme trehalase is gaining interest in insect physiology as it regulates energy metabolism and glucose generation via trehalose catabolism. The two forms of insect trehalase namely, Tre-1 and Tre-2, are important in energy supply, growth, metamorphosis, stress recovery, chitin synthesis and insect flight. Insect trehalase has not been reviewed in depth and the information available is quite scattered. The present mini review discusses our recent understanding of the regulation, mechanism and biochemical characterization of insect trehalase with respect to its physiological role in vital life functions. We also highlight the molecular and biochemical properties of insect trehalase that makes it amenable to competitive inhibition by most glycosidase inhibitors. Due to its crucial role in carbon metabolism in insects, application of inhibitors against trehalose can form a promising area towards formulating strategies for insect pest control. SN - 1460-2423 UR - https://www.unboundmedicine.com/medline/citation/25429048/Insect_trehalase:_physiological_significance_and_potential_applications_ L2 - https://academic.oup.com/glycob/article-lookup/doi/10.1093/glycob/cwu125 DB - PRIME DP - Unbound Medicine ER -