Tags

Type your tag names separated by a space and hit enter

Effect of curcumin in mice model of vincristine-induced neuropathy.
Pharm Biol. 2015 Jun; 53(6):838-48.PB

Abstract

CONTEXT

Curcumin exhibits a wide spectrum of biological activities which include neuroprotective, antinociceptive, anti-inflammatory, and antioxidant activity.

OBJECTIVE

The present study evaluates the effect of curcumin in vincristine-induced neuropathy in a mice model.

MATERIALS AND METHODS

Vincristine sulfate (0.1 mg/kg, i.p. for 10 consecutive days) was administered to mice to induce neuropathy. Pain behavior was assessed at different days, i.e., 0, 7, 10, and 14 d. Sciatic nerve total calcium, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), nitric oxide (NO), and lipid peroxidation (LPO) were also estimated after the 14th day of study. Pregabalin (10 mg/kg, p.o.) and curcumin (15, 30, and 60 mg/kg, p.o.) were administered for 14 consecutive days.

RESULTS

Curcumin at 60 mg/kg significantly attenuated the vincristine-induced neuropathic pain manifestations in terms of thermal hyperalgesia (p < 0.001) and allodynia (p < 0.001); mechanical hyperalgesia (p < 0.001); functional loss (p < 0.001); and in the delayed phase of formalin test (p < 0.001). Curcumin at 30 and 60 mg/kg exhibited significant changes (p < 0.001) in antioxidant levels and in total calcium levels in vincristine-injected mice.

CONCLUSION

Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristine-induced neuropathy which may be due to its multiple actions including antinociceptive, calcium inhibitory, and antioxidant effect.

Authors+Show Affiliations

Department of Pharmacology, PSG College of Pharmacy , Coimbatore, Tamil Nadu , India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25429779

Citation

Babu, Anand, et al. "Effect of Curcumin in Mice Model of Vincristine-induced Neuropathy." Pharmaceutical Biology, vol. 53, no. 6, 2015, pp. 838-48.
Babu A, Prasanth KG, Balaji B. Effect of curcumin in mice model of vincristine-induced neuropathy. Pharm Biol. 2015;53(6):838-48.
Babu, A., Prasanth, K. G., & Balaji, B. (2015). Effect of curcumin in mice model of vincristine-induced neuropathy. Pharmaceutical Biology, 53(6), 838-48. https://doi.org/10.3109/13880209.2014.943247
Babu A, Prasanth KG, Balaji B. Effect of Curcumin in Mice Model of Vincristine-induced Neuropathy. Pharm Biol. 2015;53(6):838-48. PubMed PMID: 25429779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of curcumin in mice model of vincristine-induced neuropathy. AU - Babu,Anand, AU - Prasanth,K G, AU - Balaji,Bhaskar, Y1 - 2014/11/28/ PY - 2014/11/29/entrez PY - 2014/11/29/pubmed PY - 2015/12/17/medline KW - Antinociceptive KW - allodynia KW - chemotherapy KW - formalin test KW - hyperalgesia KW - neuroprotective KW - pain KW - sciatic functional index SP - 838 EP - 48 JF - Pharmaceutical biology JO - Pharm Biol VL - 53 IS - 6 N2 - CONTEXT: Curcumin exhibits a wide spectrum of biological activities which include neuroprotective, antinociceptive, anti-inflammatory, and antioxidant activity. OBJECTIVE: The present study evaluates the effect of curcumin in vincristine-induced neuropathy in a mice model. MATERIALS AND METHODS: Vincristine sulfate (0.1 mg/kg, i.p. for 10 consecutive days) was administered to mice to induce neuropathy. Pain behavior was assessed at different days, i.e., 0, 7, 10, and 14 d. Sciatic nerve total calcium, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), nitric oxide (NO), and lipid peroxidation (LPO) were also estimated after the 14th day of study. Pregabalin (10 mg/kg, p.o.) and curcumin (15, 30, and 60 mg/kg, p.o.) were administered for 14 consecutive days. RESULTS: Curcumin at 60 mg/kg significantly attenuated the vincristine-induced neuropathic pain manifestations in terms of thermal hyperalgesia (p < 0.001) and allodynia (p < 0.001); mechanical hyperalgesia (p < 0.001); functional loss (p < 0.001); and in the delayed phase of formalin test (p < 0.001). Curcumin at 30 and 60 mg/kg exhibited significant changes (p < 0.001) in antioxidant levels and in total calcium levels in vincristine-injected mice. CONCLUSION: Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristine-induced neuropathy which may be due to its multiple actions including antinociceptive, calcium inhibitory, and antioxidant effect. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/25429779/Effect_of_curcumin_in_mice_model_of_vincristine_induced_neuropathy_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2014.943247 DB - PRIME DP - Unbound Medicine ER -