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Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures.
Cancer Causes Control 2015; 26(2):219-229CC

Abstract

PURPOSE

A body shape index (ABSI) has been proposed as a possible improvement over waist circumference (WC) as a marker of abdominal adiposity because it removes the correlation of WC with body mass index (BMI) and with height. We assessed the association of ABSI with four obesity-related cancers compared to that of other anthropometric measures of adiposity.

METHODS

We used data from the Women's Health Initiative, a large cohort of postmenopausal women, recruited between 1993 and 1998 and followed until September 2013, to assess the associations of ABSI and other anthropometric measures with risk of cancers of the breast, endometrium, colorectum, and kidney. The four comparison anthropometric measures were BMI, WC, waist circumference-to-height ratio (WHtR), and waist-hip ratio (WHR). Over a median of 12.7 years of follow-up, among 143,901 women, we identified 7,039 invasive breast cancers, 1,157 endometrial cancers, 1,908 colorectal cancers, and 376 kidney cancers. We used Cox proportional hazards models to estimate the association of quintiles of the five measures with risk of the four cancers.

RESULTS

Unlike the other anthropometric indices, ABSI was not associated with increased risk of breast or endometrial cancer. BMI and WC were comparable as predictors of breast and endometrial cancer, and these associations were unchanged after mutual adjustment. For colorectal and kidney cancers, ABSI was a significant predictor comparable to BMI; however, WC showed the strongest association with colorectal cancer, and WC, WHtR, and WHR all showed stronger associations with kidney cancer.

CONCLUSION

In contrast to other anthropometric measures, ABSI showed no association with risk of breast or endometrial cancer and was more weakly associated with risk of colorectal and kidney cancers compared to more established measures of central adiposity.

Authors+Show Affiliations

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. geoffrey.kabat@einstein.yu.edu.Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.Department of Preventive Medicine, School of Medicine, Stony Brook University, Stony Brook, NY, USA.Department of Medicine, Arizona Cancer Center, Tucson, AZ, USA.Department of Epidemiology, School of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.Department of Public Health Sciences, School of Medicine, University of California at Davis, Davis, CA, USA.Department of Medicine, Stanford University, Stanford, CA, USA.Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.

Pub Type(s)

Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25430815

Citation

Kabat, Geoffrey C., et al. "Risk of Breast, Endometrial, Colorectal, and Renal Cancers in Postmenopausal Women in Association With a Body Shape Index and Other Anthropometric Measures." Cancer Causes & Control : CCC, vol. 26, no. 2, 2015, pp. 219-229.
Kabat GC, Xue X, Kamensky V, et al. Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures. Cancer Causes Control. 2015;26(2):219-229.
Kabat, G. C., Xue, X., Kamensky, V., Lane, D., Bea, J. W., Chen, C., ... Rohan, T. E. (2015). Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures. Cancer Causes & Control : CCC, 26(2), pp. 219-229. doi:10.1007/s10552-014-0501-4.
Kabat GC, et al. Risk of Breast, Endometrial, Colorectal, and Renal Cancers in Postmenopausal Women in Association With a Body Shape Index and Other Anthropometric Measures. Cancer Causes Control. 2015;26(2):219-229. PubMed PMID: 25430815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures. AU - Kabat,Geoffrey C, AU - Xue,Xiaonan, AU - Kamensky,Victor, AU - Lane,Dorothy, AU - Bea,Jennifer W, AU - Chen,Chu, AU - Qi,Lihong, AU - Stefanick,Marcia L, AU - Chlebowski,Rowan T, AU - Wactawski-Wende,Jean, AU - Wassertheil-Smoller,Sylvia, AU - Rohan,Thomas E, Y1 - 2014/11/28/ PY - 2014/09/30/received PY - 2014/11/15/accepted PY - 2014/11/29/entrez PY - 2014/11/29/pubmed PY - 2016/3/30/medline SP - 219 EP - 229 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 26 IS - 2 N2 - PURPOSE: A body shape index (ABSI) has been proposed as a possible improvement over waist circumference (WC) as a marker of abdominal adiposity because it removes the correlation of WC with body mass index (BMI) and with height. We assessed the association of ABSI with four obesity-related cancers compared to that of other anthropometric measures of adiposity. METHODS: We used data from the Women's Health Initiative, a large cohort of postmenopausal women, recruited between 1993 and 1998 and followed until September 2013, to assess the associations of ABSI and other anthropometric measures with risk of cancers of the breast, endometrium, colorectum, and kidney. The four comparison anthropometric measures were BMI, WC, waist circumference-to-height ratio (WHtR), and waist-hip ratio (WHR). Over a median of 12.7 years of follow-up, among 143,901 women, we identified 7,039 invasive breast cancers, 1,157 endometrial cancers, 1,908 colorectal cancers, and 376 kidney cancers. We used Cox proportional hazards models to estimate the association of quintiles of the five measures with risk of the four cancers. RESULTS: Unlike the other anthropometric indices, ABSI was not associated with increased risk of breast or endometrial cancer. BMI and WC were comparable as predictors of breast and endometrial cancer, and these associations were unchanged after mutual adjustment. For colorectal and kidney cancers, ABSI was a significant predictor comparable to BMI; however, WC showed the strongest association with colorectal cancer, and WC, WHtR, and WHR all showed stronger associations with kidney cancer. CONCLUSION: In contrast to other anthropometric measures, ABSI showed no association with risk of breast or endometrial cancer and was more weakly associated with risk of colorectal and kidney cancers compared to more established measures of central adiposity. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/25430815/Risk_of_breast_endometrial_colorectal_and_renal_cancers_in_postmenopausal_women_in_association_with_a_body_shape_index_and_other_anthropometric_measures_ L2 - https://doi.org/10.1007/s10552-014-0501-4 DB - PRIME DP - Unbound Medicine ER -