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Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial.
Oral Health Prev Dent 2015; 13(4):309-15OH

Abstract

PURPOSE

To compare the efficacy of an Aloe vera mouthwash with a benzydamine mouthwash in the alleviation of radiation- induced mucositis in head and neck cancer patients using a triple-blind, randomised controlled trial.

MATERIALS AND METHODS

Twenty-six eligible head and neck cancer patients who were to receive conventional radiation therapy at the radiation oncology department were randomised to receive an Aloe vera mouthwash or a benzydamine mouthwash. Mucositis severity was assessed during the course of radiation therapy using the WHO grading system.

RESULTS

At baseline, there was no difference in the distribution of mucositis severity between the two groups. The mean interval between radiation therapy and onset of mucositis was similar for both groups (Aloe vera 15.69±7.77 days, benzydamine 15.85±12.96 days). The mean interval between the start of radiation therapy and the maximum severity of mucositis were was also similar in both the Aloe vera and benzydamine groups (Aloe vera 23.38±10.75 days, benzydamine 23.54±15.45 days). Mean changes of mucositis severity over time in both groups were statistically similar and the effect of both treatments did not change signficantly with time (p=0.09).

CONCLUSION

Aloe vera mouthwash was as beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis and showed no side effects. The Aloe vera mouthwash could be an alternative agent in the treatment of radiation-induced mucositis in patients with head and neck cancers.

Authors

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Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25431805

Citation

Sahebjamee, Mahnaz, et al. "Comparative Efficacy of Aloe Vera and Benzydamine Mouthwashes On Radiation-induced Oral Mucositis: a Triple-blind, Randomised, Controlled Clinical Trial." Oral Health & Preventive Dentistry, vol. 13, no. 4, 2015, pp. 309-15.
Sahebjamee M, Mansourian A, Hajimirzamohammad M, et al. Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial. Oral Health Prev Dent. 2015;13(4):309-15.
Sahebjamee, M., Mansourian, A., Hajimirzamohammad, M., Mohammad, H. M., Zadeh, M. T., Bekhradi, R., ... Doroudgar, K. (2015). Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial. Oral Health & Preventive Dentistry, 13(4), pp. 309-15. doi:10.3290/j.ohpd.a33091.
Sahebjamee M, et al. Comparative Efficacy of Aloe Vera and Benzydamine Mouthwashes On Radiation-induced Oral Mucositis: a Triple-blind, Randomised, Controlled Clinical Trial. Oral Health Prev Dent. 2015;13(4):309-15. PubMed PMID: 25431805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial. AU - Sahebjamee,Mahnaz, AU - Mansourian,Arash, AU - Hajimirzamohammad,Mohammad, AU - Mohammad,Haji Mirza Mohammad, AU - Zadeh,Mohsen Taghi, AU - Bekhradi,Reza, AU - Kazemian,Ali, AU - Manifar,Soheila, AU - Ashnagar,Sajjad, AU - Doroudgar,Kiavash, PY - 2014/11/29/entrez PY - 2014/11/29/pubmed PY - 2016/1/8/medline SP - 309 EP - 15 JF - Oral health & preventive dentistry JO - Oral Health Prev Dent VL - 13 IS - 4 N2 - PURPOSE: To compare the efficacy of an Aloe vera mouthwash with a benzydamine mouthwash in the alleviation of radiation- induced mucositis in head and neck cancer patients using a triple-blind, randomised controlled trial. MATERIALS AND METHODS: Twenty-six eligible head and neck cancer patients who were to receive conventional radiation therapy at the radiation oncology department were randomised to receive an Aloe vera mouthwash or a benzydamine mouthwash. Mucositis severity was assessed during the course of radiation therapy using the WHO grading system. RESULTS: At baseline, there was no difference in the distribution of mucositis severity between the two groups. The mean interval between radiation therapy and onset of mucositis was similar for both groups (Aloe vera 15.69±7.77 days, benzydamine 15.85±12.96 days). The mean interval between the start of radiation therapy and the maximum severity of mucositis were was also similar in both the Aloe vera and benzydamine groups (Aloe vera 23.38±10.75 days, benzydamine 23.54±15.45 days). Mean changes of mucositis severity over time in both groups were statistically similar and the effect of both treatments did not change signficantly with time (p=0.09). CONCLUSION: Aloe vera mouthwash was as beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis and showed no side effects. The Aloe vera mouthwash could be an alternative agent in the treatment of radiation-induced mucositis in patients with head and neck cancers. SN - 1602-1622 UR - https://www.unboundmedicine.com/medline/citation/25431805/Comparative_Efficacy_of_Aloe_vera_and_Benzydamine_Mouthwashes_on_Radiation_induced_Oral_Mucositis:_A_Triple_blind_Randomised_Controlled_Clinical_Trial_ L2 - http://ohpd.quintessenz.de/index.php?doc=abstract&abstractID=33091/ DB - PRIME DP - Unbound Medicine ER -