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Mechanisms of nerve injury in leprosy.
Clin Dermatol. 2015 Jan-Feb; 33(1):46-54.CD

Abstract

All patients with leprosy have some degree of nerve involvement. Perineural inflammation is the histopathologic hallmark of leprosy, and this localization may reflect a vascular route of entry of Mycobacterium leprae into nerves. Once inside nerves, M. leprae are ingested by Schwann cells, with a wide array of consequences. Axonal atrophy may occur early in this process; ultimately, affected nerves undergo segmental demyelination. Knowledge of the mechanisms of nerve injury in leprosy has been greatly limited by the minimal opportunities to study affected nerves in man. The nine-banded armadillo provides the only animal model of the pathogenesis of M. leprae infection. New tools available for this model enable the study and correlation of events occurring in epidermal nerve fibers, dermal nerves, and nerve trunks, including neurophysiologic parameters, bacterial load, and changes in gene transcription in both neural and inflammatory cells. The armadillo model is likely to enhance understanding of the mechanisms of nerve injury in leprosy and offers a means of testing proposed interventions.

Authors+Show Affiliations

Director, National Hansen's Disease Programs, Baton Rouge, Louisiana. Electronic address: dscollard@hrsa.gov.Laboratory Research Branch, National Hansen's Disease Programs at LSU, Baton Rouge, Louisiana.Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

25432810

Citation

Scollard, David M., et al. "Mechanisms of Nerve Injury in Leprosy." Clinics in Dermatology, vol. 33, no. 1, 2015, pp. 46-54.
Scollard DM, Truman RW, Ebenezer GJ. Mechanisms of nerve injury in leprosy. Clin Dermatol. 2015;33(1):46-54.
Scollard, D. M., Truman, R. W., & Ebenezer, G. J. (2015). Mechanisms of nerve injury in leprosy. Clinics in Dermatology, 33(1), 46-54. https://doi.org/10.1016/j.clindermatol.2014.07.008
Scollard DM, Truman RW, Ebenezer GJ. Mechanisms of Nerve Injury in Leprosy. Clin Dermatol. 2015 Jan-Feb;33(1):46-54. PubMed PMID: 25432810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of nerve injury in leprosy. AU - Scollard,David M, AU - Truman,Richard W, AU - Ebenezer,Gigi J, PY - 2014/11/30/entrez PY - 2014/11/30/pubmed PY - 2015/8/6/medline SP - 46 EP - 54 JF - Clinics in dermatology JO - Clin Dermatol VL - 33 IS - 1 N2 - All patients with leprosy have some degree of nerve involvement. Perineural inflammation is the histopathologic hallmark of leprosy, and this localization may reflect a vascular route of entry of Mycobacterium leprae into nerves. Once inside nerves, M. leprae are ingested by Schwann cells, with a wide array of consequences. Axonal atrophy may occur early in this process; ultimately, affected nerves undergo segmental demyelination. Knowledge of the mechanisms of nerve injury in leprosy has been greatly limited by the minimal opportunities to study affected nerves in man. The nine-banded armadillo provides the only animal model of the pathogenesis of M. leprae infection. New tools available for this model enable the study and correlation of events occurring in epidermal nerve fibers, dermal nerves, and nerve trunks, including neurophysiologic parameters, bacterial load, and changes in gene transcription in both neural and inflammatory cells. The armadillo model is likely to enhance understanding of the mechanisms of nerve injury in leprosy and offers a means of testing proposed interventions. SN - 1879-1131 UR - https://www.unboundmedicine.com/medline/citation/25432810/Mechanisms_of_nerve_injury_in_leprosy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0738-081X(14)00150-3 DB - PRIME DP - Unbound Medicine ER -