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The armadillo as an animal model and reservoir host for Mycobacterium leprae.
Clin Dermatol. 2015 Jan-Feb; 33(1):108-15.CD

Abstract

Apart from humans, armadillos are the only known natural hosts of Mycobacterium leprae. They are well developed as hosts for in vivo propagation of M leprae and are advancing as models for studying the pathogenesis of leprosy and translational research. Armadillos are immunologically intact. They exhibit the full Ridley-Jopling spectrum of histopathologic responses to M leprae and uniquely manifest extensive neurological involvement that closely recapitulates human leprosy. In addition, free-ranging armadillos in some regions are known to harbor a naturally occurring infection with M leprae, and zoonotic transmission between armadillos and humans has been implicated in a large number of new case presentations. We review the role of the armadillo as a model for leprosy and reservoir for human infection.

Authors+Show Affiliations

Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana; Department of Health Human Services, Health Resources and Services Administration, National Hansen's Disease Program, Baton Rouge, Louisiana.Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana; Department of Health Human Services, Health Resources and Services Administration, National Hansen's Disease Program, Baton Rouge, Louisiana.Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana; Department of Health Human Services, Health Resources and Services Administration, National Hansen's Disease Program, Baton Rouge, Louisiana.Department of Health Human Services, Health Resources and Services Administration, National Hansen's Disease Program, Baton Rouge, Louisiana. Electronic address: rtruman@HRSA.gov.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

25432816

Citation

Balamayooran, Gayathriy, et al. "The Armadillo as an Animal Model and Reservoir Host for Mycobacterium Leprae." Clinics in Dermatology, vol. 33, no. 1, 2015, pp. 108-15.
Balamayooran G, Pena M, Sharma R, et al. The armadillo as an animal model and reservoir host for Mycobacterium leprae. Clin Dermatol. 2015;33(1):108-15.
Balamayooran, G., Pena, M., Sharma, R., & Truman, R. W. (2015). The armadillo as an animal model and reservoir host for Mycobacterium leprae. Clinics in Dermatology, 33(1), 108-15. https://doi.org/10.1016/j.clindermatol.2014.07.001
Balamayooran G, et al. The Armadillo as an Animal Model and Reservoir Host for Mycobacterium Leprae. Clin Dermatol. 2015 Jan-Feb;33(1):108-15. PubMed PMID: 25432816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The armadillo as an animal model and reservoir host for Mycobacterium leprae. AU - Balamayooran,Gayathriy, AU - Pena,Maria, AU - Sharma,Rahul, AU - Truman,Richard W, PY - 2014/11/30/entrez PY - 2014/11/30/pubmed PY - 2015/8/6/medline SP - 108 EP - 15 JF - Clinics in dermatology JO - Clin Dermatol VL - 33 IS - 1 N2 - Apart from humans, armadillos are the only known natural hosts of Mycobacterium leprae. They are well developed as hosts for in vivo propagation of M leprae and are advancing as models for studying the pathogenesis of leprosy and translational research. Armadillos are immunologically intact. They exhibit the full Ridley-Jopling spectrum of histopathologic responses to M leprae and uniquely manifest extensive neurological involvement that closely recapitulates human leprosy. In addition, free-ranging armadillos in some regions are known to harbor a naturally occurring infection with M leprae, and zoonotic transmission between armadillos and humans has been implicated in a large number of new case presentations. We review the role of the armadillo as a model for leprosy and reservoir for human infection. SN - 1879-1131 UR - https://www.unboundmedicine.com/medline/citation/25432816/The_armadillo_as_an_animal_model_and_reservoir_host_for_Mycobacterium_leprae_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0738-081X(14)00143-6 DB - PRIME DP - Unbound Medicine ER -