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[Efficacy and safety of transdermal fentanyl patches for opioid initiation in patients with gastrointestinal obstruction].
Gan To Kagaku Ryoho. 2014 Nov; 41(11):1401-5.GT

Abstract

The transdermal fentanyl patch (TDF) can be used when switching from other opioids; therefore, little is known about the efficacy and safety of TDF patches applied for opioid initiation. However, TDF patches have been applied for opioid initiation in gastrointestinal cancer patients with gastrointestinal obstruction. In this study, we retrospectively investigated 12 gastrointestinal cancer patients to evaluate the efficacy and frequency of adverse effects of TDF patches compared to oral oxycodone (OXY) for opioid initiation. The frequency of adverse effects such as nausea, somnolence, and constipation in the TDF patch group was 25%, 41.7%, and 8.3%, respectively. No severe adverse effects were observed, and there was no significant difference between the TDF patch and OXY groups. Moreover, according to the numerical pain rating scale(ranging from 0 [no pain] to 10 [worst possible pain]), the pain intensity in the TDF patch group decreased from 5.42 on the first day to 3.33 after 3 days (p=0.0377), and 2.67 after 7 days (p=0.0089), with no significant difference between groups. Our study results suggest that TDF patches applied for opioid initiation may be useful for gastrointestinal cancer patients with gastrointestinal obstruction.

Authors+Show Affiliations

Miyoshi T
Dept. of Pharmacy, National Hospital Organization Kyushu Medical Center.
Yamauchi H
No affiliation info available
Misumi N
No affiliation info available
Goto T
No affiliation info available
Kai S
No affiliation info available
Yoshida E
No affiliation info available
Nishino T
No affiliation info available
Hasuo Y
No affiliation info available

MeSH

AdultAgedAged, 80 and overAnalgesics, OpioidFemaleFentanylGastric Outlet ObstructionHumansIntestinal ObstructionMaleMiddle AgedPalliative CareTransdermal Patch

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

25434443

Citation

Miyoshi, Takanori, et al. "[Efficacy and Safety of Transdermal Fentanyl Patches for Opioid Initiation in Patients With Gastrointestinal Obstruction]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 41, no. 11, 2014, pp. 1401-5.
Miyoshi T, Yamauchi H, Misumi N, et al. [Efficacy and safety of transdermal fentanyl patches for opioid initiation in patients with gastrointestinal obstruction]. Gan To Kagaku Ryoho. 2014;41(11):1401-5.
Miyoshi, T., Yamauchi, H., Misumi, N., Goto, T., Kai, S., Yoshida, E., Nishino, T., & Hasuo, Y. (2014). [Efficacy and safety of transdermal fentanyl patches for opioid initiation in patients with gastrointestinal obstruction]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 41(11), 1401-5.
Miyoshi T, et al. [Efficacy and Safety of Transdermal Fentanyl Patches for Opioid Initiation in Patients With Gastrointestinal Obstruction]. Gan To Kagaku Ryoho. 2014;41(11):1401-5. PubMed PMID: 25434443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Efficacy and safety of transdermal fentanyl patches for opioid initiation in patients with gastrointestinal obstruction]. AU - Miyoshi,Takanori, AU - Yamauchi,Hiroko, AU - Misumi,Nobuhiro, AU - Goto,Takashi, AU - Kai,Saisei, AU - Yoshida,Eiko, AU - Nishino,Takashi, AU - Hasuo,Yasuyuki, PY - 2014/12/2/entrez PY - 2014/12/2/pubmed PY - 2015/1/21/medline SP - 1401 EP - 5 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 41 IS - 11 N2 - The transdermal fentanyl patch (TDF) can be used when switching from other opioids; therefore, little is known about the efficacy and safety of TDF patches applied for opioid initiation. However, TDF patches have been applied for opioid initiation in gastrointestinal cancer patients with gastrointestinal obstruction. In this study, we retrospectively investigated 12 gastrointestinal cancer patients to evaluate the efficacy and frequency of adverse effects of TDF patches compared to oral oxycodone (OXY) for opioid initiation. The frequency of adverse effects such as nausea, somnolence, and constipation in the TDF patch group was 25%, 41.7%, and 8.3%, respectively. No severe adverse effects were observed, and there was no significant difference between the TDF patch and OXY groups. Moreover, according to the numerical pain rating scale(ranging from 0 [no pain] to 10 [worst possible pain]), the pain intensity in the TDF patch group decreased from 5.42 on the first day to 3.33 after 3 days (p=0.0377), and 2.67 after 7 days (p=0.0089), with no significant difference between groups. Our study results suggest that TDF patches applied for opioid initiation may be useful for gastrointestinal cancer patients with gastrointestinal obstruction. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/25434443/[Efficacy_and_safety_of_transdermal_fentanyl_patches_for_opioid_initiation_in_patients_with_gastrointestinal_obstruction]_ DB - PRIME DP - Unbound Medicine ER -