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[Effects-of combined calories restriction and polyunsaturated fatty acids on colitis in rats].
Wei Sheng Yan Jiu. 2014 Sep; 43(5):793-6, 804.WS

Abstract

OBJECTIVE

To explore the effect of n-6 and n-3 polyunsaturated fatty acids combined with calorie restriction(CR) in DSS induced ulcerative colitis rats.

METHODS

Forty female rats were randomly divided into five groups, control group, model group, CR group, 5:1 PUFA ad libitum group, 5: 1 PUFA CR group. CR groups provided with a limited daily food allotment of 60% of that eaten by the ad libitum animals for 14 weeks. Ulcerative colitis model in rats were given 5. 0% dextran sulfate sodium in their drinking water for 7 days.

RESULTS

5:1 PUFA CR group significantly decreased body weight, disease activity index, macroscopic and histological score compared to model group. In addition, administration of 5: 1 PUFA CR effectively inhibited MPO activity. The levels of TNF-α and IL-6 in the serum with colitis were decreased by 5: 1 PUFA CR (P <0. 05).

CONCLUSION

These results suggest that combination of calories restriction and n-6/n-3 =5:1 PUFA may be more beneficial in attenuating the progression of DSS induced ulcerative colitis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

25438537

Citation

Qian, Yan, et al. "[Effects-of Combined Calories Restriction and Polyunsaturated Fatty Acids On Colitis in Rats]." Wei Sheng Yan Jiu = Journal of Hygiene Research, vol. 43, no. 5, 2014, pp. 793-6, 804.
Qian Y, Zhang Y, Liu H, et al. [Effects-of combined calories restriction and polyunsaturated fatty acids on colitis in rats]. Wei Sheng Yan Jiu. 2014;43(5):793-6, 804.
Qian, Y., Zhang, Y., Liu, H., Wang, L., Li, X., & Qiu, F. (2014). [Effects-of combined calories restriction and polyunsaturated fatty acids on colitis in rats]. Wei Sheng Yan Jiu = Journal of Hygiene Research, 43(5), 793-6, 804.
Qian Y, et al. [Effects-of Combined Calories Restriction and Polyunsaturated Fatty Acids On Colitis in Rats]. Wei Sheng Yan Jiu. 2014;43(5):793-6, 804. PubMed PMID: 25438537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects-of combined calories restriction and polyunsaturated fatty acids on colitis in rats]. AU - Qian,Yan, AU - Zhang,Ying, AU - Liu,Hui, AU - Wang,Lei, AU - Li,Xiuhua, AU - Qiu,Fubin, PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/5/30/medline SP - 793-6, 804 JF - Wei sheng yan jiu = Journal of hygiene research JO - Wei Sheng Yan Jiu VL - 43 IS - 5 N2 - OBJECTIVE: To explore the effect of n-6 and n-3 polyunsaturated fatty acids combined with calorie restriction(CR) in DSS induced ulcerative colitis rats. METHODS: Forty female rats were randomly divided into five groups, control group, model group, CR group, 5:1 PUFA ad libitum group, 5: 1 PUFA CR group. CR groups provided with a limited daily food allotment of 60% of that eaten by the ad libitum animals for 14 weeks. Ulcerative colitis model in rats were given 5. 0% dextran sulfate sodium in their drinking water for 7 days. RESULTS: 5:1 PUFA CR group significantly decreased body weight, disease activity index, macroscopic and histological score compared to model group. In addition, administration of 5: 1 PUFA CR effectively inhibited MPO activity. The levels of TNF-α and IL-6 in the serum with colitis were decreased by 5: 1 PUFA CR (P <0. 05). CONCLUSION: These results suggest that combination of calories restriction and n-6/n-3 =5:1 PUFA may be more beneficial in attenuating the progression of DSS induced ulcerative colitis. SN - 1000-8020 UR - https://www.unboundmedicine.com/medline/citation/25438537/[Effects_of_combined_calories_restriction_and_polyunsaturated_fatty_acids_on_colitis_in_rats]_ L2 - https://medlineplus.gov/ulcerativecolitis.html DB - PRIME DP - Unbound Medicine ER -