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Light alcohol consumption plays a protective role against non-alcoholic fatty liver disease in Japanese men with metabolic syndrome.
Liver Int. 2015 Jun; 35(6):1707-14.LI

Abstract

BACKGROUND & AIMS

Although excess alcohol consumption has been believed to cause liver injury, light alcohol consumption (LAC) has been reported to play a protective role against fatty liver in recent studies. However, the association between non-alcoholic fatty liver disease (NAFLD) and LAC in men with metabolic syndrome (MS) is unclear. The aim of this study was to examine the association between NAFLD and LAC in men with MS.

METHODS

Subjects were 1055 men with MS who underwent a regular health check-up and drank less 20 g/day of alcohol. A distinction was made between non-drinkers and light drinkers and the association between NAFLD and LAC in men with MS was elucidated. NAFLD was referred as fatty liver with alanine aminotransferase (ALT) levels ≧31 IU/L in this study.

RESULTS

Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and the prevalence of NAFLD were significantly lower in light drinkers than in non-drinkers. Logistic regression analysis showed body mass index (BMI), waist circumference (WC), uric acid (UA), haemoglobin A1c (HbA1c), visceral fat type MS and LAC (odds ratios: 0.654; 95% confidence intervals: 0.473-0.906; <0.05) were significant predictors of the prevalence of NAFLD.

CONCLUSION

The prevalence of NAFLD in light drinkers was significantly lower than in non-drinkers, and supporting previous reports studying the general population, LAC is one of the significant predictors of a decreased prevalence of NAFLD in men with MS.

Authors+Show Affiliations

Department of General Medicine and Community Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. Department of Gastroenterology, Kagawa Prefectural Cancer Detection Center, Takamatsu, Japan.Department of General Medicine and Community Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.Department of Gastroenterology and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.Department of Gastroenterology and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.Department of Gastroenterology and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.Department of Gastroenterology and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.Department of Internal Medicine, Tsurugi Municipal Handa Hospital, Tokushima, Japan.Department of Gastroenterology and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25438866

Citation

Sogabe, Masahiro, et al. "Light Alcohol Consumption Plays a Protective Role Against Non-alcoholic Fatty Liver Disease in Japanese Men With Metabolic Syndrome." Liver International : Official Journal of the International Association for the Study of the Liver, vol. 35, no. 6, 2015, pp. 1707-14.
Sogabe M, Okahisa T, Taniguchi T, et al. Light alcohol consumption plays a protective role against non-alcoholic fatty liver disease in Japanese men with metabolic syndrome. Liver Int. 2015;35(6):1707-14.
Sogabe, M., Okahisa, T., Taniguchi, T., Tomonari, T., Tanaka, T., Tanaka, H., Nakasono, M., & Takayama, T. (2015). Light alcohol consumption plays a protective role against non-alcoholic fatty liver disease in Japanese men with metabolic syndrome. Liver International : Official Journal of the International Association for the Study of the Liver, 35(6), 1707-14. https://doi.org/10.1111/liv.12754
Sogabe M, et al. Light Alcohol Consumption Plays a Protective Role Against Non-alcoholic Fatty Liver Disease in Japanese Men With Metabolic Syndrome. Liver Int. 2015;35(6):1707-14. PubMed PMID: 25438866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Light alcohol consumption plays a protective role against non-alcoholic fatty liver disease in Japanese men with metabolic syndrome. AU - Sogabe,Masahiro, AU - Okahisa,Toshiya, AU - Taniguchi,Tatsuya, AU - Tomonari,Tetsu, AU - Tanaka,Takahiro, AU - Tanaka,Hironori, AU - Nakasono,Masahiko, AU - Takayama,Tetsuji, Y1 - 2015/01/21/ PY - 2014/07/29/received PY - 2014/11/20/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2016/2/18/medline KW - NAFLD KW - light alcohol consumption KW - men KW - metabolic syndrome KW - ultrasonography SP - 1707 EP - 14 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int VL - 35 IS - 6 N2 - BACKGROUND & AIMS: Although excess alcohol consumption has been believed to cause liver injury, light alcohol consumption (LAC) has been reported to play a protective role against fatty liver in recent studies. However, the association between non-alcoholic fatty liver disease (NAFLD) and LAC in men with metabolic syndrome (MS) is unclear. The aim of this study was to examine the association between NAFLD and LAC in men with MS. METHODS: Subjects were 1055 men with MS who underwent a regular health check-up and drank less 20 g/day of alcohol. A distinction was made between non-drinkers and light drinkers and the association between NAFLD and LAC in men with MS was elucidated. NAFLD was referred as fatty liver with alanine aminotransferase (ALT) levels ≧31 IU/L in this study. RESULTS: Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and the prevalence of NAFLD were significantly lower in light drinkers than in non-drinkers. Logistic regression analysis showed body mass index (BMI), waist circumference (WC), uric acid (UA), haemoglobin A1c (HbA1c), visceral fat type MS and LAC (odds ratios: 0.654; 95% confidence intervals: 0.473-0.906; <0.05) were significant predictors of the prevalence of NAFLD. CONCLUSION: The prevalence of NAFLD in light drinkers was significantly lower than in non-drinkers, and supporting previous reports studying the general population, LAC is one of the significant predictors of a decreased prevalence of NAFLD in men with MS. SN - 1478-3231 UR - https://www.unboundmedicine.com/medline/citation/25438866/Light_alcohol_consumption_plays_a_protective_role_against_non_alcoholic_fatty_liver_disease_in_Japanese_men_with_metabolic_syndrome_ L2 - https://doi.org/10.1111/liv.12754 DB - PRIME DP - Unbound Medicine ER -