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Relation of right ventricular mass and volume to functional health status in repaired tetralogy of Fallot.
Am J Cardiol. 2014 Dec 15; 114(12):1896-901.AJ

Abstract

After repair of tetralogy of Fallot, right ventricular (RV) mass and mass:volume ratio may reflect RV remodeling and adverse outcomes. This study aimed to evaluate the relation of RV mass to functional health status and subsequent adverse RV remodeling and to determine whether RV mass measurement in systole could improve reproducibility. In 53 patients with tetralogy of Fallot (median 29 years old) who previously underwent cardiovascular magnetic resonance and completed the Short Form 36, version 2 (Optum, Eden Prairie, MN), short-axis images were analyzed for RV end-diastolic volume and diastolic and systolic mass, indexed to body surface area. The most recent subsequent cardiovascular magnetic resonance study (before pulmonary valve or conduit replacement) was evaluated for change in RV end-diastolic volume and ejection fraction. Diastolic indexed mass ≥37.3 g/m(2) (odds ratio 7.6, p = 0.02) predicted decreased general health scores. In patients with normal RV ejection fraction, indexed mass correlated with Physical Component Summary and general health scores. RV diastolic mass:volume ratio >0.2 had a strong association with subsequent increase in RV end-diastolic volume (odds ratio 26.1, p = 0.002). Systolic RV mass measurement had excellent correlation with diastolic measurement (r = 0.97, p <0.0001), but did not improve intraobserver or interobserver variability. In conclusion, RV mass relates to functional health status and adverse RV remodeling and can be measured with good reproducibility. RV mass should be routinely evaluated in this population and is best measured in diastole; further study is necessary to evaluate longitudinal changes in functional health status and RV parameters.

Authors+Show Affiliations

Division of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan; Section of Pediatric Radiology, Department of Radiology, University of Michigan, Ann Arbor, Michigan. Electronic address: jimmyl@umich.edu.Division of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan.Division of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan.Division of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan.Section of Pediatric Radiology, Department of Radiology, University of Michigan, Ann Arbor, Michigan.Division of Cardiothoracic Radiology, Department of Radiology, University of Michigan, Ann Arbor, Michigan.Division of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan; Section of Pediatric Radiology, Department of Radiology, University of Michigan, Ann Arbor, Michigan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25438919

Citation

Lu, Jimmy C., et al. "Relation of Right Ventricular Mass and Volume to Functional Health Status in Repaired Tetralogy of Fallot." The American Journal of Cardiology, vol. 114, no. 12, 2014, pp. 1896-901.
Lu JC, Christensen JT, Yu S, et al. Relation of right ventricular mass and volume to functional health status in repaired tetralogy of Fallot. Am J Cardiol. 2014;114(12):1896-901.
Lu, J. C., Christensen, J. T., Yu, S., Donohue, J. E., Ghadimi Mahani, M., Agarwal, P. P., & Dorfman, A. L. (2014). Relation of right ventricular mass and volume to functional health status in repaired tetralogy of Fallot. The American Journal of Cardiology, 114(12), 1896-901. https://doi.org/10.1016/j.amjcard.2014.09.027
Lu JC, et al. Relation of Right Ventricular Mass and Volume to Functional Health Status in Repaired Tetralogy of Fallot. Am J Cardiol. 2014 Dec 15;114(12):1896-901. PubMed PMID: 25438919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of right ventricular mass and volume to functional health status in repaired tetralogy of Fallot. AU - Lu,Jimmy C, AU - Christensen,Jason T, AU - Yu,Sunkyung, AU - Donohue,Janet E, AU - Ghadimi Mahani,Maryam, AU - Agarwal,Prachi P, AU - Dorfman,Adam L, Y1 - 2014/09/28/ PY - 2014/07/03/received PY - 2014/09/17/revised PY - 2014/09/17/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/3/4/medline SP - 1896 EP - 901 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 114 IS - 12 N2 - After repair of tetralogy of Fallot, right ventricular (RV) mass and mass:volume ratio may reflect RV remodeling and adverse outcomes. This study aimed to evaluate the relation of RV mass to functional health status and subsequent adverse RV remodeling and to determine whether RV mass measurement in systole could improve reproducibility. In 53 patients with tetralogy of Fallot (median 29 years old) who previously underwent cardiovascular magnetic resonance and completed the Short Form 36, version 2 (Optum, Eden Prairie, MN), short-axis images were analyzed for RV end-diastolic volume and diastolic and systolic mass, indexed to body surface area. The most recent subsequent cardiovascular magnetic resonance study (before pulmonary valve or conduit replacement) was evaluated for change in RV end-diastolic volume and ejection fraction. Diastolic indexed mass ≥37.3 g/m(2) (odds ratio 7.6, p = 0.02) predicted decreased general health scores. In patients with normal RV ejection fraction, indexed mass correlated with Physical Component Summary and general health scores. RV diastolic mass:volume ratio >0.2 had a strong association with subsequent increase in RV end-diastolic volume (odds ratio 26.1, p = 0.002). Systolic RV mass measurement had excellent correlation with diastolic measurement (r = 0.97, p <0.0001), but did not improve intraobserver or interobserver variability. In conclusion, RV mass relates to functional health status and adverse RV remodeling and can be measured with good reproducibility. RV mass should be routinely evaluated in this population and is best measured in diastole; further study is necessary to evaluate longitudinal changes in functional health status and RV parameters. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/25438919/Relation_of_right_ventricular_mass_and_volume_to_functional_health_status_in_repaired_tetralogy_of_Fallot_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(14)01855-4 DB - PRIME DP - Unbound Medicine ER -