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Alcohol consumption and incidence of type 2 diabetes. Results from the CoLaus study.
Nutr Metab Cardiovasc Dis 2015; 25(1):75-84NM

Abstract

BACKGROUND AND AIMS

Moderate alcohol consumption has been shown to decrease the risk of type 2 diabetes (T2DM), but whether this association is also valid for impaired fasting glucose (IFG) is less well known. We aimed at assessing the impact of alcohol consumption and of type of alcoholic beverage on the incidence of T2DM and T2DM + IFG.

METHODS AND RESULTS

As many as 4765 participants (2613 women, mean age 51.7 ± 10.5 years) without T2DM at baseline and followed for an average of 5.5 years. The association between alcohol consumption, type of alcoholic beverage and outcomes was assessed after adjustment for a validated T2DM risk score. During follow-up 284 participants developed T2DM and 643 developed IFG. On bivariate analysis, alcohol consumption was positively associated with the risk of developing T2DM or T2DM + IFG. Moderate (14-27 units/week) alcohol consumption tended to be associated with a lower risk of T2DM, but no protective effect was found for T2DM + IFG. Multivariable-adjusted odds ratio (OR) and (95% confidence interval) for T2DM: 0.89 (0.65-1.22), 0.66 (0.42-1.03) and 1.63 (0.93-2.84) for 1-13, 14-27 and 28 + units/week, respectively (p for quadratic trend < 0.005). For T2DM + IFG, the corresponding ORs were 1.09 (0.90-1.32), 1.33 (1.02-1.74) and 1.54 (0.99-2.39), respectively, p for trend = 0.03. No specific effect of alcoholic beverage (wine, beer or spirits) was found for T2DM or for T2DM + IFG.

CONCLUSION

Moderate alcohol consumption is associated with a reduced risk of developing T2DM, but not of developing T2DM + IFG. No specific effect of type of alcoholic beverage was found.

Authors+Show Affiliations

Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland. Electronic address: Pedro-Manuel.Marques-Vidal@chuv.ch.Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland. Electronic address: Peter.Vollenweider@chuv.ch.Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland. Electronic address: Gerard.Waeber@chuv.ch.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25439660

Citation

Marques-Vidal, P, et al. "Alcohol Consumption and Incidence of Type 2 Diabetes. Results From the CoLaus Study." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 25, no. 1, 2015, pp. 75-84.
Marques-Vidal P, Vollenweider P, Waeber G. Alcohol consumption and incidence of type 2 diabetes. Results from the CoLaus study. Nutr Metab Cardiovasc Dis. 2015;25(1):75-84.
Marques-Vidal, P., Vollenweider, P., & Waeber, G. (2015). Alcohol consumption and incidence of type 2 diabetes. Results from the CoLaus study. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 25(1), pp. 75-84. doi:10.1016/j.numecd.2014.08.010.
Marques-Vidal P, Vollenweider P, Waeber G. Alcohol Consumption and Incidence of Type 2 Diabetes. Results From the CoLaus Study. Nutr Metab Cardiovasc Dis. 2015;25(1):75-84. PubMed PMID: 25439660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and incidence of type 2 diabetes. Results from the CoLaus study. AU - Marques-Vidal,P, AU - Vollenweider,P, AU - Waeber,G, Y1 - 2014/09/16/ PY - 2014/05/01/received PY - 2014/07/25/revised PY - 2014/08/18/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/9/17/medline KW - Alcohol consumption KW - Impaired fasting glucose KW - Incidence KW - Prospective study KW - Switzerland KW - Type 2 diabetes SP - 75 EP - 84 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 25 IS - 1 N2 - BACKGROUND AND AIMS: Moderate alcohol consumption has been shown to decrease the risk of type 2 diabetes (T2DM), but whether this association is also valid for impaired fasting glucose (IFG) is less well known. We aimed at assessing the impact of alcohol consumption and of type of alcoholic beverage on the incidence of T2DM and T2DM + IFG. METHODS AND RESULTS: As many as 4765 participants (2613 women, mean age 51.7 ± 10.5 years) without T2DM at baseline and followed for an average of 5.5 years. The association between alcohol consumption, type of alcoholic beverage and outcomes was assessed after adjustment for a validated T2DM risk score. During follow-up 284 participants developed T2DM and 643 developed IFG. On bivariate analysis, alcohol consumption was positively associated with the risk of developing T2DM or T2DM + IFG. Moderate (14-27 units/week) alcohol consumption tended to be associated with a lower risk of T2DM, but no protective effect was found for T2DM + IFG. Multivariable-adjusted odds ratio (OR) and (95% confidence interval) for T2DM: 0.89 (0.65-1.22), 0.66 (0.42-1.03) and 1.63 (0.93-2.84) for 1-13, 14-27 and 28 + units/week, respectively (p for quadratic trend < 0.005). For T2DM + IFG, the corresponding ORs were 1.09 (0.90-1.32), 1.33 (1.02-1.74) and 1.54 (0.99-2.39), respectively, p for trend = 0.03. No specific effect of alcoholic beverage (wine, beer or spirits) was found for T2DM or for T2DM + IFG. CONCLUSION: Moderate alcohol consumption is associated with a reduced risk of developing T2DM, but not of developing T2DM + IFG. No specific effect of type of alcoholic beverage was found. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/25439660/Alcohol_consumption_and_incidence_of_type_2_diabetes__Results_from_the_CoLaus_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(14)00283-X DB - PRIME DP - Unbound Medicine ER -