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Circulating anti-Müllerian hormone levels in relation to nutritional status and selected adipokines levels in polycystic ovary syndrome.
Clin Endocrinol (Oxf) 2015; 83(1):98-104CE

Abstract

OBJECTIVE

The aim of the study was to analyse the relationship between nutritional status, selected adipokines and plasma anti-Müllerian hormone (AMH) levels in women with polycystic ovary syndrome (PCOS).

STUDY DESIGN PATIENTS AND MEASUREMENTS

A prospective, cross-sectional study, involving 87 PCOS (48 obese) women and 67 non-PCOS women (36 obese). Anthropometric parameters were measured, and body composition was determined by the bioimpedance method. Fasting serum glucose, androgens, FSH, LH, SHBG, insulin, AMH, apelin-36, adiponectin, leptin and omentin-1 were measured.

RESULTS

Plasma AMH levels were significantly higher in PCOS compared to the non-PCOS group (7.8 ± 4.3 ng/ml vs 44 ± 2.4 ng/ml; P < 0.001). Furthermore, AMH levels were higher in both PCOS and non-PCOS normal weight than in obese subgroups (8.9 ± 4.4 ng/ml vs 7.0 ± 4.0 ng/ml; P < 0.05 and 5.1 ± 2.4 ng/ml vs 3.9 ± 2.3 ng/ml; P < 0.05). There were negative correlations between AMH levels and anthropometric parameters (body mass, BMI, fat mass and percentage, as well as waist circumference) and plasma omentin-1 concentrations (R = -0.28, P < 0.001; R = -0.30, P < 0.001; R = -0.36, P < 0.001; R = -0.34, P < 0.001; R = -0.23, P < 0.01; and R = -0.20, P < 0.05, respectively) in all study groups. In multiple regression analysis, circulating AMH level variability was explained by omentin-1 levels and anthropometric parameters (excluding waist circumference).

CONCLUSIONS

In this observational study, nutritional status appears to be the main factor influencing circulating AMH levels independent of PCOS. The observed AMH association with omentin-1 levels suggests that this adipokine may be a link between hormonal dysfunction of adipose tissue related to obesity and decreased AMH secretion.

Authors+Show Affiliations

Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.Department of Endocrinological Gynecology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.Division of Statistics in Sosnowiec, Faculty of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.Pathophysiology Unit, Department of Pathophysiology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.Department of Endocrinological Gynecology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25440474

Citation

Olszanecka-Glinianowicz, Magdalena, et al. "Circulating anti-Müllerian Hormone Levels in Relation to Nutritional Status and Selected Adipokines Levels in Polycystic Ovary Syndrome." Clinical Endocrinology, vol. 83, no. 1, 2015, pp. 98-104.
Olszanecka-Glinianowicz M, Madej P, Owczarek A, et al. Circulating anti-Müllerian hormone levels in relation to nutritional status and selected adipokines levels in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2015;83(1):98-104.
Olszanecka-Glinianowicz, M., Madej, P., Owczarek, A., Chudek, J., & Skałba, P. (2015). Circulating anti-Müllerian hormone levels in relation to nutritional status and selected adipokines levels in polycystic ovary syndrome. Clinical Endocrinology, 83(1), pp. 98-104. doi:10.1111/cen.12687.
Olszanecka-Glinianowicz M, et al. Circulating anti-Müllerian Hormone Levels in Relation to Nutritional Status and Selected Adipokines Levels in Polycystic Ovary Syndrome. Clin Endocrinol (Oxf). 2015;83(1):98-104. PubMed PMID: 25440474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating anti-Müllerian hormone levels in relation to nutritional status and selected adipokines levels in polycystic ovary syndrome. AU - Olszanecka-Glinianowicz,Magdalena, AU - Madej,Paweł, AU - Owczarek,Aleksander, AU - Chudek,Jerzy, AU - Skałba,Piotr, Y1 - 2015/02/03/ PY - 2014/05/03/received PY - 2014/11/19/revised PY - 2014/11/26/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2016/3/16/medline SP - 98 EP - 104 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 83 IS - 1 N2 - OBJECTIVE: The aim of the study was to analyse the relationship between nutritional status, selected adipokines and plasma anti-Müllerian hormone (AMH) levels in women with polycystic ovary syndrome (PCOS). STUDY DESIGN PATIENTS AND MEASUREMENTS: A prospective, cross-sectional study, involving 87 PCOS (48 obese) women and 67 non-PCOS women (36 obese). Anthropometric parameters were measured, and body composition was determined by the bioimpedance method. Fasting serum glucose, androgens, FSH, LH, SHBG, insulin, AMH, apelin-36, adiponectin, leptin and omentin-1 were measured. RESULTS: Plasma AMH levels were significantly higher in PCOS compared to the non-PCOS group (7.8 ± 4.3 ng/ml vs 44 ± 2.4 ng/ml; P < 0.001). Furthermore, AMH levels were higher in both PCOS and non-PCOS normal weight than in obese subgroups (8.9 ± 4.4 ng/ml vs 7.0 ± 4.0 ng/ml; P < 0.05 and 5.1 ± 2.4 ng/ml vs 3.9 ± 2.3 ng/ml; P < 0.05). There were negative correlations between AMH levels and anthropometric parameters (body mass, BMI, fat mass and percentage, as well as waist circumference) and plasma omentin-1 concentrations (R = -0.28, P < 0.001; R = -0.30, P < 0.001; R = -0.36, P < 0.001; R = -0.34, P < 0.001; R = -0.23, P < 0.01; and R = -0.20, P < 0.05, respectively) in all study groups. In multiple regression analysis, circulating AMH level variability was explained by omentin-1 levels and anthropometric parameters (excluding waist circumference). CONCLUSIONS: In this observational study, nutritional status appears to be the main factor influencing circulating AMH levels independent of PCOS. The observed AMH association with omentin-1 levels suggests that this adipokine may be a link between hormonal dysfunction of adipose tissue related to obesity and decreased AMH secretion. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/25440474/Circulating_anti_Müllerian_hormone_levels_in_relation_to_nutritional_status_and_selected_adipokines_levels_in_polycystic_ovary_syndrome_ L2 - https://doi.org/10.1111/cen.12687 DB - PRIME DP - Unbound Medicine ER -