Tags

Type your tag names separated by a space and hit enter

Gastroprotective effect of the iridoid fraction from Barleria prionitis leaves on experimentally-induced gastric ulceration.
Chin J Nat Med. 2014 Oct; 12(10):738-44.CJ

Abstract

AIM

To study the gastroprotective effect and in vivo antioxidant potential of a standardized iridoid fraction from B. prionitis leaves (BPE) against different gastric ulcer models in rats.

METHOD

The standardized iridoid fraction from BPE at 50, 100, and 200 mg/kg body weight was administered orally, twice daily for 5 days for prevention from aspirin, ethanol, cold-restraint stress (CRS), and pylorus ligation (PL)-induced ulcers. Estimation of the antioxidant enzyme activity was carried out in a CRS-induced ulcer model, and various gastric secretion parameters including volume of gastric juice, acid output, and pH value were estimated in the PL-induced ulcer model.

RESULTS

BPE showed a dose-dependent ulcer protective effect in PL (18.67%-66.26% protection), aspirin (24.65%-63.25% protection), CRS (20.77%-59.42% protection), and EtOH (16.93%-77.04% protection)-induced ulcers. BPE treatment in PL-rats showed a decrease in acid-pepsin secretion, and enhanced mucin and mucosal glycoproteins. However, BPE reduced the ulcer index with significant decrease in LPO (P < 0.01-0.001), SOD (P < 0.01-0.001), and an increase in CAT (P < 0.01-0.001), activity in the CRS-induced model.

CONCLUSION

The data shows that the iridoid fraction from BPE possesses anti-ulcerogenic and antioxidant potential.

Authors+Show Affiliations

Department of Pharmacy, Rameshwaram Institutes of Technology & Management, Lucknow 226020, Uttar Pradesh, India.Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam, India.Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam, India.Pharmacognosy & Ethnopharmacology Div., National Botanical Research Institute (CSIR), Rana Pratap Marg, Lucknow 226001, Uttar Pradesh, India. Electronic address: sunil_pharmachem90@yahoo.co.in.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25443366

Citation

Jaiswal, Sunil K., et al. "Gastroprotective Effect of the Iridoid Fraction From Barleria Prionitis Leaves On Experimentally-induced Gastric Ulceration." Chinese Journal of Natural Medicines, vol. 12, no. 10, 2014, pp. 738-44.
Jaiswal SK, Dubey MK, Das S, et al. Gastroprotective effect of the iridoid fraction from Barleria prionitis leaves on experimentally-induced gastric ulceration. Chin J Nat Med. 2014;12(10):738-44.
Jaiswal, S. K., Dubey, M. K., Das, S., & Rao, C. h. V. (2014). Gastroprotective effect of the iridoid fraction from Barleria prionitis leaves on experimentally-induced gastric ulceration. Chinese Journal of Natural Medicines, 12(10), 738-44. https://doi.org/10.1016/S1875-5364(14)60113-8
Jaiswal SK, et al. Gastroprotective Effect of the Iridoid Fraction From Barleria Prionitis Leaves On Experimentally-induced Gastric Ulceration. Chin J Nat Med. 2014;12(10):738-44. PubMed PMID: 25443366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroprotective effect of the iridoid fraction from Barleria prionitis leaves on experimentally-induced gastric ulceration. AU - Jaiswal,Sunil K, AU - Dubey,Mukesh K, AU - Das,Sanjib, AU - Rao,Ch V, Y1 - 2014/10/31/ PY - 2013/05/17/received PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/7/17/medline KW - Anti-ulcer activity KW - Antioxidant enzymes KW - Barleria prionitis KW - HPTLC KW - Iridoid SP - 738 EP - 44 JF - Chinese journal of natural medicines JO - Chin J Nat Med VL - 12 IS - 10 N2 - AIM: To study the gastroprotective effect and in vivo antioxidant potential of a standardized iridoid fraction from B. prionitis leaves (BPE) against different gastric ulcer models in rats. METHOD: The standardized iridoid fraction from BPE at 50, 100, and 200 mg/kg body weight was administered orally, twice daily for 5 days for prevention from aspirin, ethanol, cold-restraint stress (CRS), and pylorus ligation (PL)-induced ulcers. Estimation of the antioxidant enzyme activity was carried out in a CRS-induced ulcer model, and various gastric secretion parameters including volume of gastric juice, acid output, and pH value were estimated in the PL-induced ulcer model. RESULTS: BPE showed a dose-dependent ulcer protective effect in PL (18.67%-66.26% protection), aspirin (24.65%-63.25% protection), CRS (20.77%-59.42% protection), and EtOH (16.93%-77.04% protection)-induced ulcers. BPE treatment in PL-rats showed a decrease in acid-pepsin secretion, and enhanced mucin and mucosal glycoproteins. However, BPE reduced the ulcer index with significant decrease in LPO (P < 0.01-0.001), SOD (P < 0.01-0.001), and an increase in CAT (P < 0.01-0.001), activity in the CRS-induced model. CONCLUSION: The data shows that the iridoid fraction from BPE possesses anti-ulcerogenic and antioxidant potential. SN - 1875-5364 UR - https://www.unboundmedicine.com/medline/citation/25443366/Gastroprotective_effect_of_the_iridoid_fraction_from_Barleria_prionitis_leaves_on_experimentally_induced_gastric_ulceration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1875-5364(14)60113-8 DB - PRIME DP - Unbound Medicine ER -