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Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS).
Atherosclerosis 2014; 237(1):361-8A

Abstract

BACKGROUND

Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited.

METHODS

We used 1975-1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40-69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (<8 h after meal) participants.

RESULTS

During the 22-year follow-up, 284 (165 men and 119 women) developed ischemic heart disease and 666 (349 men and 317 women) ischemic stroke. After adjustment for age, sex and known cardiovascular risk factors, multivariable hazard ratios (95%CI) of ischemic cardiovascular disease (ischemic heart disease and ischemic stroke) for the highest versus lowest quartiles of triglycerides were 1.71 (1.14-2.59), P for trend = 0.013, for fasting participants and 1.60 (1.25-2.05), P for trend <0.001, for non-fasting participants. The positive associations did not differ between fasting and non-fasting men, while they were strong for non-fasting women. They were stronger for ischemic heart disease than for ischemic stroke. After further adjustment for HDL-cholesterol, these associations were slightly attenuated, but remained statistically significant.

CONCLUSION

Non-fasting as well as fasting triglycerides are predictive of risk of ischemic cardiovascular disease for Japanese men, as are non-fasting triglycerides for women.

Authors+Show Affiliations

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan. Electronic address: iso@pbhel.med.osaka-u.ac.jp.Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan; Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan; Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan.Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan.Chiba Prefectural Institute of Public Health, Nitona Government Office Building, 666-2 Nitonacho, Chuo-ku, Chiba, 260-8715, Japan.Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.Total Medical Support Center, Ehime University Hospital, 454 Shitsukawa, Toon, 791-0295, Japan.Department of Environmental Health and Social Medicine, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, 791-0295, Japan.Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25443874

Citation

Iso, Hiroyasu, et al. "Fasting and Non-fasting Triglycerides and Risk of Ischemic Cardiovascular Disease in Japanese Men and Women: the Circulatory Risk in Communities Study (CIRCS)." Atherosclerosis, vol. 237, no. 1, 2014, pp. 361-8.
Iso H, Imano H, Yamagishi K, et al. Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS). Atherosclerosis. 2014;237(1):361-8.
Iso, H., Imano, H., Yamagishi, K., Ohira, T., Cui, R., Noda, H., ... Kitamura, A. (2014). Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS). Atherosclerosis, 237(1), pp. 361-8. doi:10.1016/j.atherosclerosis.2014.08.028.
Iso H, et al. Fasting and Non-fasting Triglycerides and Risk of Ischemic Cardiovascular Disease in Japanese Men and Women: the Circulatory Risk in Communities Study (CIRCS). Atherosclerosis. 2014;237(1):361-8. PubMed PMID: 25443874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS). AU - Iso,Hiroyasu, AU - Imano,Hironori, AU - Yamagishi,Kazumasa, AU - Ohira,Tetsuya, AU - Cui,Renzhe, AU - Noda,Hiroyuki, AU - Sato,Shinichi, AU - Kiyama,Masahiko, AU - Okada,Takeo, AU - Hitsumoto,Shinichi, AU - Tanigawa,Takeshi, AU - Kitamura,Akihiko, AU - ,, Y1 - 2014/09/06/ PY - 2014/03/27/received PY - 2014/07/29/revised PY - 2014/08/08/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/8/19/medline KW - Fasting KW - Follow-up studies KW - Ischemic heart disease KW - Ischemic stroke KW - Non-fasting KW - Triglycerides SP - 361 EP - 8 JF - Atherosclerosis JO - Atherosclerosis VL - 237 IS - 1 N2 - BACKGROUND: Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited. METHODS: We used 1975-1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40-69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (<8 h after meal) participants. RESULTS: During the 22-year follow-up, 284 (165 men and 119 women) developed ischemic heart disease and 666 (349 men and 317 women) ischemic stroke. After adjustment for age, sex and known cardiovascular risk factors, multivariable hazard ratios (95%CI) of ischemic cardiovascular disease (ischemic heart disease and ischemic stroke) for the highest versus lowest quartiles of triglycerides were 1.71 (1.14-2.59), P for trend = 0.013, for fasting participants and 1.60 (1.25-2.05), P for trend <0.001, for non-fasting participants. The positive associations did not differ between fasting and non-fasting men, while they were strong for non-fasting women. They were stronger for ischemic heart disease than for ischemic stroke. After further adjustment for HDL-cholesterol, these associations were slightly attenuated, but remained statistically significant. CONCLUSION: Non-fasting as well as fasting triglycerides are predictive of risk of ischemic cardiovascular disease for Japanese men, as are non-fasting triglycerides for women. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/25443874/Fasting_and_non_fasting_triglycerides_and_risk_of_ischemic_cardiovascular_disease_in_Japanese_men_and_women:_the_Circulatory_Risk_in_Communities_Study__CIRCS__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(14)01355-0 DB - PRIME DP - Unbound Medicine ER -