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Metabolic syndrome and lower urinary tract symptoms in patients with benign prostatic enlargement: a possible link to storage symptoms.
Urology. 2014 Nov; 84(5):1181-7.U

Abstract

OBJECTIVE

To evaluate the association between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) in patients with benign prostatic enlargement (BPE).

MATERIALS AND METHODS

From 2009 onward, a consecutive series of patients with LUTS-BPE were enrolled. Patients were evaluated using the International Prostate Symptom Score (IPSS) and ultrasonographic prostate volume. Body mass index, waist circumference, and blood pressure were measured. Blood samples were collected for prostate-specific antigen levels, fasting glucose levels, triglyceride levels, high-density lipoprotein levels, and testosterone levels. MetS was defined according to Adult Treatment Panel III (ATP III). The risk of detecting LUTS as a function of MetS was evaluated using the logistic regression analysis.

RESULTS

A total of 431 patients were enrolled with a median age and prostate-specific antigen level of 67 years (61-73 years) and 3 ng/mL (2.2-4.3 ng/mL), respectively; median body mass index was 27 kg/m2 (25-29 kg/m(2)); median testosterone was 3.9 ng/mL (3.1-4.7 ng/mL); median IPSS was 8 (4-14), median prostate volume was 43 mL (35-56 mL). One hundred three of 431 patients (23.8%) presented with a MetS. Patients with MetS presented a higher IPSS storage subscore (4; interquartile range, 2-7 vs 3; interquartile range 1-7; P = .002). On multivariate analysis, the presence of MetS was associated with an increased risk of an IPSS storage subscore ≥4 (odds ratio, 1.782; 95% confidence interval, 1.045-3.042; P = .030).

CONCLUSION

In our single-center study, MetS is associated with an increased risk of storage symptoms in patients with BPE. Although these results should be confirmed, and the pathophysiology is yet to be understood, it can be assumed that MetS and its metabolic components should be considered as possible factors involved in LUTS-BPE pathogenesis.

Authors+Show Affiliations

Department of Urology, Ospedale Sant'Andrea, University "La Sapienza", Roma, Italy. Electronic address: cosimodenunzio@virgilio.it.Department of Urology, Ospedale Padre Pio Da Pietrelcina, Vasto, Italy.Department of Urology, Careggi Hospital, University of Florence, Firenze, Italy.Department of Urology, Ospedale Padre Pio Da Pietrelcina, Vasto, Italy.Department of Urology, Careggi Hospital, University of Florence, Firenze, Italy.Department of Urology, Ospedale Sant'Andrea, University "La Sapienza", Roma, Italy.Department of Urology, Policlinico Umberto I, Roma, Italy.Department of Urology, Ospedale Sant'Andrea, University "La Sapienza", Roma, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25443931

Citation

De Nunzio, Cosimo, et al. "Metabolic Syndrome and Lower Urinary Tract Symptoms in Patients With Benign Prostatic Enlargement: a Possible Link to Storage Symptoms." Urology, vol. 84, no. 5, 2014, pp. 1181-7.
De Nunzio C, Cindolo L, Gacci M, et al. Metabolic syndrome and lower urinary tract symptoms in patients with benign prostatic enlargement: a possible link to storage symptoms. Urology. 2014;84(5):1181-7.
De Nunzio, C., Cindolo, L., Gacci, M., Pellegrini, F., Carini, M., Lombardo, R., Franco, G., & Tubaro, A. (2014). Metabolic syndrome and lower urinary tract symptoms in patients with benign prostatic enlargement: a possible link to storage symptoms. Urology, 84(5), 1181-7. https://doi.org/10.1016/j.urology.2014.07.018
De Nunzio C, et al. Metabolic Syndrome and Lower Urinary Tract Symptoms in Patients With Benign Prostatic Enlargement: a Possible Link to Storage Symptoms. Urology. 2014;84(5):1181-7. PubMed PMID: 25443931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and lower urinary tract symptoms in patients with benign prostatic enlargement: a possible link to storage symptoms. AU - De Nunzio,Cosimo, AU - Cindolo,Luca, AU - Gacci,Mauro, AU - Pellegrini,Fabrizio, AU - Carini,Marco, AU - Lombardo,Riccardo, AU - Franco,Giorgio, AU - Tubaro,Andrea, Y1 - 2014/10/24/ PY - 2014/05/24/received PY - 2014/07/03/revised PY - 2014/07/07/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/2/13/medline SP - 1181 EP - 7 JF - Urology JO - Urology VL - 84 IS - 5 N2 - OBJECTIVE: To evaluate the association between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) in patients with benign prostatic enlargement (BPE). MATERIALS AND METHODS: From 2009 onward, a consecutive series of patients with LUTS-BPE were enrolled. Patients were evaluated using the International Prostate Symptom Score (IPSS) and ultrasonographic prostate volume. Body mass index, waist circumference, and blood pressure were measured. Blood samples were collected for prostate-specific antigen levels, fasting glucose levels, triglyceride levels, high-density lipoprotein levels, and testosterone levels. MetS was defined according to Adult Treatment Panel III (ATP III). The risk of detecting LUTS as a function of MetS was evaluated using the logistic regression analysis. RESULTS: A total of 431 patients were enrolled with a median age and prostate-specific antigen level of 67 years (61-73 years) and 3 ng/mL (2.2-4.3 ng/mL), respectively; median body mass index was 27 kg/m2 (25-29 kg/m(2)); median testosterone was 3.9 ng/mL (3.1-4.7 ng/mL); median IPSS was 8 (4-14), median prostate volume was 43 mL (35-56 mL). One hundred three of 431 patients (23.8%) presented with a MetS. Patients with MetS presented a higher IPSS storage subscore (4; interquartile range, 2-7 vs 3; interquartile range 1-7; P = .002). On multivariate analysis, the presence of MetS was associated with an increased risk of an IPSS storage subscore ≥4 (odds ratio, 1.782; 95% confidence interval, 1.045-3.042; P = .030). CONCLUSION: In our single-center study, MetS is associated with an increased risk of storage symptoms in patients with BPE. Although these results should be confirmed, and the pathophysiology is yet to be understood, it can be assumed that MetS and its metabolic components should be considered as possible factors involved in LUTS-BPE pathogenesis. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/25443931/Metabolic_syndrome_and_lower_urinary_tract_symptoms_in_patients_with_benign_prostatic_enlargement:_a_possible_link_to_storage_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(14)00721-3 DB - PRIME DP - Unbound Medicine ER -