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Very urgent carotid endarterectomy does not increase the procedural risk.
Eur J Vasc Endovasc Surg. 2015 Feb; 49(2):129-36.EJ

Abstract

OBJECTIVES

The timing of CEA for symptomatic internal carotid artery (ICA) stenosis remains a matter of controversy. Recent registry data showed a significantly increased risk, especially in the very early days after the onset of symptoms. In this study the outcome of CEA in the hyperacute phase has been investigated.

METHODS

The outcome of CEA for symptomatic ICA stenosis between January 2004 and December 2013 has been retrospectively analyzed. Patients were divided into four timing groups: surgery within 0 and 2 days, between 3 and 7 days, 8 and 14 days, and thereafter. The post-operative 30 day stroke and death rates were assessed.

RESULTS

A total of 761 symptomatic patients (40.1% with transient ischemic attack [TIA], 21.3% with amaurosis fugax, and 38.6% with ischemic stroke) were included, with an overall peri-operative stroke and death rate of 3.3%. A stroke and death rate of 4.4% (9/206) for surgery within 0 and 2 days, 1.8% (4/219) between 3 and 7 days, 4.4% (6/136) between 8 and 14 days, and 2.5% (5/200) in the period thereafter (p = .25 for the difference between the groups) was observed. The timing of surgery did not influence the peri-operative outcome in a multivariate regression analysis (OR 0.93 [0.63-1.36], p = .71).

CONCLUSIONS

These data show that very urgent surgery in symptomatic patients can be performed without increased procedural risk. Given the fact that ruptured plaques with neurological symptoms carry the highest risk of a recurrent ischemic event in the first 2 days, treating patients as soon as possible to offer the highest benefit in stroke prevention is recommended.

Authors+Show Affiliations

Department of Vascular Surgery, Innsbruck Medical University, Innsbruck, Austria. Electronic address: barbara.rantner@i-med.ac.at.Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.Department of Vascular Surgery, Innsbruck Medical University, Innsbruck, Austria.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25445726

Citation

Rantner, B, et al. "Very Urgent Carotid Endarterectomy Does Not Increase the Procedural Risk." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 49, no. 2, 2015, pp. 129-36.
Rantner B, Schmidauer C, Knoflach M, et al. Very urgent carotid endarterectomy does not increase the procedural risk. Eur J Vasc Endovasc Surg. 2015;49(2):129-36.
Rantner, B., Schmidauer, C., Knoflach, M., & Fraedrich, G. (2015). Very urgent carotid endarterectomy does not increase the procedural risk. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 49(2), 129-36. https://doi.org/10.1016/j.ejvs.2014.09.006
Rantner B, et al. Very Urgent Carotid Endarterectomy Does Not Increase the Procedural Risk. Eur J Vasc Endovasc Surg. 2015;49(2):129-36. PubMed PMID: 25445726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Very urgent carotid endarterectomy does not increase the procedural risk. AU - Rantner,B, AU - Schmidauer,C, AU - Knoflach,M, AU - Fraedrich,G, Y1 - 2014/10/27/ PY - 2014/08/19/received PY - 2014/09/16/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/4/10/medline KW - Carotid endarterectomy KW - Hyperacute period KW - Internal carotid artery KW - Symptomatic stenosis SP - 129 EP - 36 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 49 IS - 2 N2 - OBJECTIVES: The timing of CEA for symptomatic internal carotid artery (ICA) stenosis remains a matter of controversy. Recent registry data showed a significantly increased risk, especially in the very early days after the onset of symptoms. In this study the outcome of CEA in the hyperacute phase has been investigated. METHODS: The outcome of CEA for symptomatic ICA stenosis between January 2004 and December 2013 has been retrospectively analyzed. Patients were divided into four timing groups: surgery within 0 and 2 days, between 3 and 7 days, 8 and 14 days, and thereafter. The post-operative 30 day stroke and death rates were assessed. RESULTS: A total of 761 symptomatic patients (40.1% with transient ischemic attack [TIA], 21.3% with amaurosis fugax, and 38.6% with ischemic stroke) were included, with an overall peri-operative stroke and death rate of 3.3%. A stroke and death rate of 4.4% (9/206) for surgery within 0 and 2 days, 1.8% (4/219) between 3 and 7 days, 4.4% (6/136) between 8 and 14 days, and 2.5% (5/200) in the period thereafter (p = .25 for the difference between the groups) was observed. The timing of surgery did not influence the peri-operative outcome in a multivariate regression analysis (OR 0.93 [0.63-1.36], p = .71). CONCLUSIONS: These data show that very urgent surgery in symptomatic patients can be performed without increased procedural risk. Given the fact that ruptured plaques with neurological symptoms carry the highest risk of a recurrent ischemic event in the first 2 days, treating patients as soon as possible to offer the highest benefit in stroke prevention is recommended. SN - 1532-2165 UR - https://www.unboundmedicine.com/medline/citation/25445726/Very_urgent_carotid_endarterectomy_does_not_increase_the_procedural_risk_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-5884(14)00524-3 DB - PRIME DP - Unbound Medicine ER -