Tags

Type your tag names separated by a space and hit enter

Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy.
J Allergy Clin Immunol. 2015 Feb; 135(2):370-8.JA

Abstract

BACKGROUND

There is growing concern that prenatal exposure to bisphenol A (BPA) and phthalates, which are widely used in consumer products, might affect susceptibility to infections and the development of allergy and asthma in children, but there are currently very few prospective studies.

OBJECTIVE

We sought to evaluate whether prenatal exposure to BPA and phthalates increases the risk of respiratory and allergic outcomes in children at various ages from birth to 7 years.

METHODS

We measured BPA and metabolites of high-molecular-weight phthalates, 4 di-(2-ethylhexyl) phthalate (DEHP) metabolites (Σ4DEHP) and mono-benzyl phthalate (MBzP), and 3 low-molecular-weight phthalate (LMWP) metabolites (Σ3LMWP) in urine samples collected during the first and third trimesters in pregnant women participating in the Infancia y Medio Ambiente-Sabadell birth cohort study. The occurrence of chest infections, bronchitis, wheeze, and eczema in children was assessed at ages 6 and 14 months and 4 and 7 years through questionnaires given to the mothers. Atopy (specific IgE measurement) and asthma (questionnaire) were assessed at ages 4 and 7 years, respectively.

RESULTS

The relative risks (RRs) of wheeze (RR, 1.20; 95% CI, 1.03-1.40; P = .02), chest infections (RR, 1.15; 95% CI, 1.00-1.32; P = .05), and bronchitis (RR, 1.18; 95% CI, 1.01-1.37; P = .04) at any age increased for each doubling in concentration of maternal urinary BPA. Σ4DEHP metabolites were associated with the same outcomes (wheeze: RR, 1.25; 95% CI, 1.04-1.50, P = .02; chest infections: RR, 1.15; 95% CI, 0.97-1.35; P = .11; bronchitis: RR, 1.20; 95% CI, 1.01-1.43; P = .04). MBzP was associated with higher risk of wheeze (RR, 1.15; 95% CI, 1.00-1.33; P = .05). The risk of asthma at age 7 years was also increased with increasing prenatal BPA, Σ4DEHP, and MBzP exposure. There were no other exposure-outcome associations.

CONCLUSIONS

Prenatal exposure to BPA and high-molecular-weight phthalates might increase the risk of asthma symptoms and respiratory tract infections throughout childhood.

Authors+Show Affiliations

Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. Electronic address: mgascon@creal.cat.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.Departamento de Química Analítica, Universidad de Córdoba, Córdoba, Spain.Departamento de Química Analítica, Universidad de Córdoba, Córdoba, Spain.Departamento de Química Analítica, Universidad de Córdoba, Córdoba, Spain.IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.Universitat Pompeu Fabra (UPF), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25445825

Citation

Gascon, Mireia, et al. "Prenatal Exposure to Bisphenol a and Phthalates and Childhood Respiratory Tract Infections and Allergy." The Journal of Allergy and Clinical Immunology, vol. 135, no. 2, 2015, pp. 370-8.
Gascon M, Casas M, Morales E, et al. Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. J Allergy Clin Immunol. 2015;135(2):370-8.
Gascon, M., Casas, M., Morales, E., Valvi, D., Ballesteros-Gómez, A., Luque, N., Rubio, S., Monfort, N., Ventura, R., Martínez, D., Sunyer, J., & Vrijheid, M. (2015). Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. The Journal of Allergy and Clinical Immunology, 135(2), 370-8. https://doi.org/10.1016/j.jaci.2014.09.030
Gascon M, et al. Prenatal Exposure to Bisphenol a and Phthalates and Childhood Respiratory Tract Infections and Allergy. J Allergy Clin Immunol. 2015;135(2):370-8. PubMed PMID: 25445825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. AU - Gascon,Mireia, AU - Casas,Maribel, AU - Morales,Eva, AU - Valvi,Damaskini, AU - Ballesteros-Gómez,Ana, AU - Luque,Noelia, AU - Rubio,Soledad, AU - Monfort,Núria, AU - Ventura,Rosa, AU - Martínez,David, AU - Sunyer,Jordi, AU - Vrijheid,Martine, Y1 - 2014/10/30/ PY - 2014/04/01/received PY - 2014/09/17/revised PY - 2014/09/22/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/4/9/medline KW - Bisphenol A KW - asthma KW - atopy KW - bronchitis KW - chest infections KW - children KW - eczema KW - phthalates KW - specific IgE KW - wheeze SP - 370 EP - 8 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 135 IS - 2 N2 - BACKGROUND: There is growing concern that prenatal exposure to bisphenol A (BPA) and phthalates, which are widely used in consumer products, might affect susceptibility to infections and the development of allergy and asthma in children, but there are currently very few prospective studies. OBJECTIVE: We sought to evaluate whether prenatal exposure to BPA and phthalates increases the risk of respiratory and allergic outcomes in children at various ages from birth to 7 years. METHODS: We measured BPA and metabolites of high-molecular-weight phthalates, 4 di-(2-ethylhexyl) phthalate (DEHP) metabolites (Σ4DEHP) and mono-benzyl phthalate (MBzP), and 3 low-molecular-weight phthalate (LMWP) metabolites (Σ3LMWP) in urine samples collected during the first and third trimesters in pregnant women participating in the Infancia y Medio Ambiente-Sabadell birth cohort study. The occurrence of chest infections, bronchitis, wheeze, and eczema in children was assessed at ages 6 and 14 months and 4 and 7 years through questionnaires given to the mothers. Atopy (specific IgE measurement) and asthma (questionnaire) were assessed at ages 4 and 7 years, respectively. RESULTS: The relative risks (RRs) of wheeze (RR, 1.20; 95% CI, 1.03-1.40; P = .02), chest infections (RR, 1.15; 95% CI, 1.00-1.32; P = .05), and bronchitis (RR, 1.18; 95% CI, 1.01-1.37; P = .04) at any age increased for each doubling in concentration of maternal urinary BPA. Σ4DEHP metabolites were associated with the same outcomes (wheeze: RR, 1.25; 95% CI, 1.04-1.50, P = .02; chest infections: RR, 1.15; 95% CI, 0.97-1.35; P = .11; bronchitis: RR, 1.20; 95% CI, 1.01-1.43; P = .04). MBzP was associated with higher risk of wheeze (RR, 1.15; 95% CI, 1.00-1.33; P = .05). The risk of asthma at age 7 years was also increased with increasing prenatal BPA, Σ4DEHP, and MBzP exposure. There were no other exposure-outcome associations. CONCLUSIONS: Prenatal exposure to BPA and high-molecular-weight phthalates might increase the risk of asthma symptoms and respiratory tract infections throughout childhood. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/25445825/Prenatal_exposure_to_bisphenol_A_and_phthalates_and_childhood_respiratory_tract_infections_and_allergy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(14)01365-7 DB - PRIME DP - Unbound Medicine ER -