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Hepatoprotective activity of ginsenosides from Panax ginseng adventitious roots against carbon tetrachloride treated hepatic injury in rats.
J Ethnopharmacol. 2014 Dec 02; 158 Pt A:442-6.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Ginseng (Panax ginseng C. A. Meyer) has a beneficial role in the treatment of various diseases including liver disorders like acute/chronic hepatotoxicity, hepatitis, hepatic fibrosis/cirrhosis and hepatocellular carcinoma.

MATERIALS AND METHODS

Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract with ginsenosides in abundance was used as an experimental material. 'Sprague-Dawley' male rats were used as experimental systems and were fed with TCMGARs extracts at doses of 30, 100, 300mg/kg body weight for two weeks to test the effect on carbon tetrachloride (CCl4) induced acute liver damage. Field cultivated Korean ginseng root extract fed rats (100mg/kg) were used as positive control. Plasma enzyme levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were assessed. Glutathione (GSH) and malondialdehyde (MDA) concentrations were also evaluated.

RESULTS

TCMGARs extracts remarkably prevented the elevation of ALT, AST, ALP and liver peroxides in CCl4-treated rats. Hepatic glutathione levels were significantly increased by the treatment with the extracts in experimental groups.

CONCLUSION

The TCMGARs rich in varied ginsenosides can afford protection against CCl4-induced hepatocellular injury.

Authors+Show Affiliations

Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea; Department of Botany, Karnatak University, Dharwad 580003, India. Electronic address: nmurthy60@yahoo.co.in.Department of Botany, Karnatak University, Dharwad 580003, India.Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea. Electronic address: paekky@chungbuk.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25446594

Citation

Niranjana Murthy, Hosakatte, et al. "Hepatoprotective Activity of Ginsenosides From Panax Ginseng Adventitious Roots Against Carbon Tetrachloride Treated Hepatic Injury in Rats." Journal of Ethnopharmacology, vol. 158 Pt A, 2014, pp. 442-6.
Niranjana Murthy H, Dandin VS, Yoeup Paek K. Hepatoprotective activity of ginsenosides from Panax ginseng adventitious roots against carbon tetrachloride treated hepatic injury in rats. J Ethnopharmacol. 2014;158 Pt A:442-6.
Niranjana Murthy, H., Dandin, V. S., & Yoeup Paek, K. (2014). Hepatoprotective activity of ginsenosides from Panax ginseng adventitious roots against carbon tetrachloride treated hepatic injury in rats. Journal of Ethnopharmacology, 158 Pt A, 442-6. https://doi.org/10.1016/j.jep.2014.10.047
Niranjana Murthy H, Dandin VS, Yoeup Paek K. Hepatoprotective Activity of Ginsenosides From Panax Ginseng Adventitious Roots Against Carbon Tetrachloride Treated Hepatic Injury in Rats. J Ethnopharmacol. 2014 Dec 2;158 Pt A:442-6. PubMed PMID: 25446594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective activity of ginsenosides from Panax ginseng adventitious roots against carbon tetrachloride treated hepatic injury in rats. AU - Niranjana Murthy,Hosakatte, AU - Dandin,Vijayalaxmi S, AU - Yoeup Paek,Kee, Y1 - 2014/10/31/ PY - 2014/07/08/received PY - 2014/09/21/revised PY - 2014/10/17/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/9/26/medline KW - Ginsenosides KW - Glutathione KW - Hepatoprotective activity KW - Lipid peroxidation KW - Mountain ginseng SP - 442 EP - 6 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 158 Pt A N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Ginseng (Panax ginseng C. A. Meyer) has a beneficial role in the treatment of various diseases including liver disorders like acute/chronic hepatotoxicity, hepatitis, hepatic fibrosis/cirrhosis and hepatocellular carcinoma. MATERIALS AND METHODS: Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract with ginsenosides in abundance was used as an experimental material. 'Sprague-Dawley' male rats were used as experimental systems and were fed with TCMGARs extracts at doses of 30, 100, 300mg/kg body weight for two weeks to test the effect on carbon tetrachloride (CCl4) induced acute liver damage. Field cultivated Korean ginseng root extract fed rats (100mg/kg) were used as positive control. Plasma enzyme levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were assessed. Glutathione (GSH) and malondialdehyde (MDA) concentrations were also evaluated. RESULTS: TCMGARs extracts remarkably prevented the elevation of ALT, AST, ALP and liver peroxides in CCl4-treated rats. Hepatic glutathione levels were significantly increased by the treatment with the extracts in experimental groups. CONCLUSION: The TCMGARs rich in varied ginsenosides can afford protection against CCl4-induced hepatocellular injury. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/25446594/Hepatoprotective_activity_of_ginsenosides_from_Panax_ginseng_adventitious_roots_against_carbon_tetrachloride_treated_hepatic_injury_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(14)00757-0 DB - PRIME DP - Unbound Medicine ER -