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Investigation of anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract.
J Ethnopharmacol. 2015 Mar 13; 162:199-206.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Stahlianthus involucratus (Zingiberaceae) has long been used in traditional medicine to treat inflammation, pain, and fever. However, no pharmacological study of this plant has been reported to confirm these activities. The aim of this study was to investigate the anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract (SiE) in animal models.

MATERIALS AND METHODS

Anti-inflammatory activity of SiE was investigated in rats using ethyl phenylpropiolate (EPP)-induced ear edema, carrageenan- and arachidonic acid (AA)-induced hind paw edema, and cotton pellet-induced granuloma formation models. Acetic acid-induced writhing response in mice and tail-flick test in rats as well as yeast-induced hyperthermia in rats were used to investigate the antinociceptive and antipyretic activities, respectively.

RESULTS

SiE significantly inhibited EPP-induced ear edema, carrageenan- and AA-induced hind paw edema. Its inhibitory effect in carrageenan-induced hind paw edema seemed to be in a dose-dependent manner. In cotton pellet-induced granuloma formation, SiE showed suppressive effects on granuloma formation but not on body weight gain and dry thymus weight. It could normalize serum alkaline phosphatase activity to nearly normal level. SiE also possessed a significant inhibitory effect, which seemed to be dose-dependent, on acetic acid-induced writhing response, whereas only at the highest dose of SiE could significantly increase test reaction time at all time-points in tail-flick test. However, no antipyretic activity was observed.

CONCLUSIONS

These results suggest that SiE possesses anti-inflammatory and antinociceptive, but not antipyretic, activities. This study therefore rationalizes the traditional use of SiE for the treatment of inflammation and pain.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address: puongtip.k@cmu.ac.th.Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.School of Medicine, Mae Fah Luang University, Chiang Rai 57100, Thailand.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25446630

Citation

Pingsusaen, Phornchai, et al. "Investigation of Anti-inflammatory, Antinociceptive and Antipyretic Activities of Stahlianthus Involucratus Rhizome Ethanol Extract." Journal of Ethnopharmacology, vol. 162, 2015, pp. 199-206.
Pingsusaen P, Kunanusorn P, Khonsung P, et al. Investigation of anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract. J Ethnopharmacol. 2015;162:199-206.
Pingsusaen, P., Kunanusorn, P., Khonsung, P., Chiranthanut, N., Panthong, A., & Rujjanawate, C. (2015). Investigation of anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract. Journal of Ethnopharmacology, 162, 199-206. https://doi.org/10.1016/j.jep.2014.10.060
Pingsusaen P, et al. Investigation of Anti-inflammatory, Antinociceptive and Antipyretic Activities of Stahlianthus Involucratus Rhizome Ethanol Extract. J Ethnopharmacol. 2015 Mar 13;162:199-206. PubMed PMID: 25446630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract. AU - Pingsusaen,Phornchai, AU - Kunanusorn,Puongtip, AU - Khonsung,Parirat, AU - Chiranthanut,Natthakarn, AU - Panthong,Ampai, AU - Rujjanawate,Chaiyong, Y1 - 2014/11/21/ PY - 2014/07/23/received PY - 2014/09/24/revised PY - 2014/10/27/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2016/3/5/medline KW - Acetic acid (PubChem CID: 176) KW - Acetone (PubChem CID: 180) KW - Anti-inflammatory KW - Antinociceptive KW - Antipyretic KW - Arachidonic acid (PubChem CID: 444899) KW - Codeine phosphate (PubChem CID: 12303736) KW - Diclofenac sodium (PubChem CID: 5018304) KW - Dimethylsulfoxide (PubChem CID: 679) KW - Ethyl phenylpropiolate (PubChem CID: 91516) KW - Lambda carrageenan KW - Prednisolone (PubChem CID: 5755) KW - Rhizome KW - Stahlianthus involucratus SP - 199 EP - 206 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 162 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Stahlianthus involucratus (Zingiberaceae) has long been used in traditional medicine to treat inflammation, pain, and fever. However, no pharmacological study of this plant has been reported to confirm these activities. The aim of this study was to investigate the anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract (SiE) in animal models. MATERIALS AND METHODS: Anti-inflammatory activity of SiE was investigated in rats using ethyl phenylpropiolate (EPP)-induced ear edema, carrageenan- and arachidonic acid (AA)-induced hind paw edema, and cotton pellet-induced granuloma formation models. Acetic acid-induced writhing response in mice and tail-flick test in rats as well as yeast-induced hyperthermia in rats were used to investigate the antinociceptive and antipyretic activities, respectively. RESULTS: SiE significantly inhibited EPP-induced ear edema, carrageenan- and AA-induced hind paw edema. Its inhibitory effect in carrageenan-induced hind paw edema seemed to be in a dose-dependent manner. In cotton pellet-induced granuloma formation, SiE showed suppressive effects on granuloma formation but not on body weight gain and dry thymus weight. It could normalize serum alkaline phosphatase activity to nearly normal level. SiE also possessed a significant inhibitory effect, which seemed to be dose-dependent, on acetic acid-induced writhing response, whereas only at the highest dose of SiE could significantly increase test reaction time at all time-points in tail-flick test. However, no antipyretic activity was observed. CONCLUSIONS: These results suggest that SiE possesses anti-inflammatory and antinociceptive, but not antipyretic, activities. This study therefore rationalizes the traditional use of SiE for the treatment of inflammation and pain. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/25446630/Investigation_of_anti_inflammatory_antinociceptive_and_antipyretic_activities_of_Stahlianthus_involucratus_rhizome_ethanol_extract_ DB - PRIME DP - Unbound Medicine ER -