Tags

Type your tag names separated by a space and hit enter

Medical genetics-based drug repurposing for Alzheimer's disease.
Brain Res Bull 2015; 110:26-9BR

Abstract

Alzheimer's disease (AD) is a disease that threatens the elderly. No efficient therapeutic method is currently available to combat AD. Drug repurposing has provided a new route for AD drug discovery, and medical genetics has shown potential in target-based drug repurposing. We compared AD-associated genes with approved drug targets and found that three are targeted by 23 approved drugs. Thus, these drugs may be used to treat AD according to the medical genetic information of the targets. In vitro and in vivo experiments revealed that four drugs, all of which are angiotensin-converting enzyme (ACE) inhibitors, had potential to treat AD.

Authors+Show Affiliations

School of Life Sciences, Shandong University of Technology, Zibo 255049, PR China. Electronic address: sleevexz@sdut.edu.cn.Agricultural Bioinformatics Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address: 1309458172@qq.com.Agricultural Bioinformatics Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address: gytang@mail.hzau.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25446738

Citation

Zhang, Xiu-Zhen, et al. "Medical Genetics-based Drug Repurposing for Alzheimer's Disease." Brain Research Bulletin, vol. 110, 2015, pp. 26-9.
Zhang XZ, Quan Y, Tang GY. Medical genetics-based drug repurposing for Alzheimer's disease. Brain Res Bull. 2015;110:26-9.
Zhang, X. Z., Quan, Y., & Tang, G. Y. (2015). Medical genetics-based drug repurposing for Alzheimer's disease. Brain Research Bulletin, 110, pp. 26-9. doi:10.1016/j.brainresbull.2014.11.003.
Zhang XZ, Quan Y, Tang GY. Medical Genetics-based Drug Repurposing for Alzheimer's Disease. Brain Res Bull. 2015;110:26-9. PubMed PMID: 25446738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medical genetics-based drug repurposing for Alzheimer's disease. AU - Zhang,Xiu-Zhen, AU - Quan,Yuan, AU - Tang,Guang-Yan, Y1 - 2014/11/22/ PY - 2014/08/08/received PY - 2014/11/12/revised PY - 2014/11/13/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/9/10/medline KW - Alzheimer's disease KW - Angiotensin-converting enzyme inhibitors KW - Drug repurposing KW - Medical genetics SP - 26 EP - 9 JF - Brain research bulletin JO - Brain Res. Bull. VL - 110 N2 - Alzheimer's disease (AD) is a disease that threatens the elderly. No efficient therapeutic method is currently available to combat AD. Drug repurposing has provided a new route for AD drug discovery, and medical genetics has shown potential in target-based drug repurposing. We compared AD-associated genes with approved drug targets and found that three are targeted by 23 approved drugs. Thus, these drugs may be used to treat AD according to the medical genetic information of the targets. In vitro and in vivo experiments revealed that four drugs, all of which are angiotensin-converting enzyme (ACE) inhibitors, had potential to treat AD. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/25446738/Medical_genetics_based_drug_repurposing_for_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(14)00186-5 DB - PRIME DP - Unbound Medicine ER -