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Differential effects of CB1 receptor agonism in behavioural tests of unconditioned and conditioned fear in adult male rats.
Behav Brain Res. 2015 Feb 15; 279:9-16.BB

Abstract

We investigated the effects of the highly selective CB1 receptor agonist ACEA and the CB1 receptor antagonist/inverse agonist AM251 on two behavioural tests of unconditioned fear, the elevated plus maze (EPM) and open field test (OFT), as well as on the recall and extinction of a conditioned auditory fear. Both ACEA and AM251 increased anxiety-like behaviour in the EPM and OFT. There was no effect of either drug on recall of the conditioned fear, and ACEA enhanced and AM251 impaired fear extinction. Further, though both the low (0.1 mg/kg) and high (0.5 mg/kg) dose of ACEA facilitated fear extinction, the low dose attenuated, and the high dose potentiated, fear induced corticosterone release suggesting independent effects of the drug on fear and stress responses. Although the extent to which cannabinoids are anxiogenic or anxiolytic has been proposed to be dose-dependent, these results indicate that the same dose has differential effects across tasks, likely based in differences in sensitivities of CB1 receptors to the agonist in the neural regions subserving unconditioned and conditioned fear.

Authors+Show Affiliations

Department of Biological Sciences, Brock University, 500 Glenridge Ave., St. Catharines, ON L2S 3A1, Canada. Electronic address: js09vp@brocku.ca.Department of Psychology, Brock University, 500 Glenridge Ave., St. Catharines, ON L2S 3A1, Canada. Electronic address: mg06mc@brocku.ca.Department of Psychology, Brock University, 500 Glenridge Ave., St. Catharines, ON L2S 3A1, Canada. Electronic address: th12iw@brocku.ca.Department of Biological Sciences, Brock University, 500 Glenridge Ave., St. Catharines, ON L2S 3A1, Canada; Department of Psychology, Brock University, 500 Glenridge Ave., St. Catharines, ON L2S 3A1, Canada. Electronic address: cmccormick@brocku.ca.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25446756

Citation

Simone, Jonathan J., et al. "Differential Effects of CB1 Receptor Agonism in Behavioural Tests of Unconditioned and Conditioned Fear in Adult Male Rats." Behavioural Brain Research, vol. 279, 2015, pp. 9-16.
Simone JJ, Green MR, Hodges TE, et al. Differential effects of CB1 receptor agonism in behavioural tests of unconditioned and conditioned fear in adult male rats. Behav Brain Res. 2015;279:9-16.
Simone, J. J., Green, M. R., Hodges, T. E., & McCormick, C. M. (2015). Differential effects of CB1 receptor agonism in behavioural tests of unconditioned and conditioned fear in adult male rats. Behavioural Brain Research, 279, 9-16. https://doi.org/10.1016/j.bbr.2014.11.012
Simone JJ, et al. Differential Effects of CB1 Receptor Agonism in Behavioural Tests of Unconditioned and Conditioned Fear in Adult Male Rats. Behav Brain Res. 2015 Feb 15;279:9-16. PubMed PMID: 25446756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of CB1 receptor agonism in behavioural tests of unconditioned and conditioned fear in adult male rats. AU - Simone,Jonathan J, AU - Green,Matthew R, AU - Hodges,Travis E, AU - McCormick,Cheryl M, Y1 - 2014/11/12/ PY - 2014/08/08/received PY - 2014/10/07/revised PY - 2014/11/05/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/8/21/medline KW - CB1 receptor agonism KW - CB1 receptor antagonism KW - Conditioned fear KW - Physiological stress KW - Unconditioned fear SP - 9 EP - 16 JF - Behavioural brain research JO - Behav. Brain Res. VL - 279 N2 - We investigated the effects of the highly selective CB1 receptor agonist ACEA and the CB1 receptor antagonist/inverse agonist AM251 on two behavioural tests of unconditioned fear, the elevated plus maze (EPM) and open field test (OFT), as well as on the recall and extinction of a conditioned auditory fear. Both ACEA and AM251 increased anxiety-like behaviour in the EPM and OFT. There was no effect of either drug on recall of the conditioned fear, and ACEA enhanced and AM251 impaired fear extinction. Further, though both the low (0.1 mg/kg) and high (0.5 mg/kg) dose of ACEA facilitated fear extinction, the low dose attenuated, and the high dose potentiated, fear induced corticosterone release suggesting independent effects of the drug on fear and stress responses. Although the extent to which cannabinoids are anxiogenic or anxiolytic has been proposed to be dose-dependent, these results indicate that the same dose has differential effects across tasks, likely based in differences in sensitivities of CB1 receptors to the agonist in the neural regions subserving unconditioned and conditioned fear. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/25446756/Differential_effects_of_CB1_receptor_agonism_in_behavioural_tests_of_unconditioned_and_conditioned_fear_in_adult_male_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(14)00741-4 DB - PRIME DP - Unbound Medicine ER -