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Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain.
Eur J Pharmacol. 2014 Dec 15; 745:69-75.EJ

Abstract

Cannabinoid (CB) receptors have emerged as an attractive therapeutic target for pain management in recent years and the interest in the use of cannabinoids is gradually increasing, particularly in patients where conventional treatments fail. Muscle pain is a major clinical problem and new pharmacological approaches are being studied. Recently, we have demonstrated that cannabinoid synthetic agonists are useful to reduce muscular pain in two animal models, where the local administration is effective. Now, we want to know if tetrahydrocannabinol (THC), a cannabinoid natural derivative with therapeutic use in humans, is also effective in reducing acute muscle pain. The antinociceptive effect of THC by systemic (i.p.) and local (i.m.) administration was tested in two animal models of acute muscle pain, rat masseter and gastrocnemius, induced by hypertonic saline (HS) injection. The drugs used were the non-selective agonist THC and two selective cannabinoid antagonists, AM251 (CB1) and AM630 (CB2). THC, i.p. and i.m. administered, reduced the nociceptive behaviours induced by HS in both muscular pain models. The antinociceptive effect induced by the systemic administration of THC was mediated by CB1 receptors in the masseter muscle whereas in gastrocnemius both CB1 and CB2 receptors participated. When THC was administered locally, only CB2 receptors were involved in the antinociceptive effect in both muscles. This study suggests that THC could be a future pharmacological option in the treatment of muscle pain. The local administration of THC could be an interesting option to treat this type of pain avoiding the central adverse effects.

Authors+Show Affiliations

Área de Farmacología y Nutrición - Unidad asociada I+D+i al Instituto de Química Médica (CSIC), Dpto. Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avda. Atenas, s/n. 28922 Alcorcón, Madrid, Spain. Electronic address: ana.bagues@urjc.es.Área de Farmacología y Nutrición - Unidad asociada I+D+i al Instituto de Química Médica (CSIC), Dpto. Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avda. Atenas, s/n. 28922 Alcorcón, Madrid, Spain. Electronic address: isabel.martin@urjc.es.Área de Farmacología y Nutrición - Unidad asociada I+D+i al Instituto de Química Médica (CSIC), Dpto. Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avda. Atenas, s/n. 28922 Alcorcón, Madrid, Spain. Electronic address: eva.sanchez@urjc.es.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25446925

Citation

Bagüés, Ana, et al. "Involvement of Central and Peripheral Cannabinoid Receptors On Antinociceptive Effect of Tetrahydrocannabinol in Muscle Pain." European Journal of Pharmacology, vol. 745, 2014, pp. 69-75.
Bagüés A, Martín MI, Sánchez-Robles EM. Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain. Eur J Pharmacol. 2014;745:69-75.
Bagüés, A., Martín, M. I., & Sánchez-Robles, E. M. (2014). Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain. European Journal of Pharmacology, 745, 69-75. https://doi.org/10.1016/j.ejphar.2014.10.016
Bagüés A, Martín MI, Sánchez-Robles EM. Involvement of Central and Peripheral Cannabinoid Receptors On Antinociceptive Effect of Tetrahydrocannabinol in Muscle Pain. Eur J Pharmacol. 2014 Dec 15;745:69-75. PubMed PMID: 25446925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain. AU - Bagüés,Ana, AU - Martín,M Isabel, AU - Sánchez-Robles,Eva M, Y1 - 2014/10/19/ PY - 2014/07/03/received PY - 2014/10/08/revised PY - 2014/10/09/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/8/25/medline KW - Cannabinoid receptors KW - Muscle pain KW - Rat KW - Tetrahydrocannabinol SP - 69 EP - 75 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 745 N2 - Cannabinoid (CB) receptors have emerged as an attractive therapeutic target for pain management in recent years and the interest in the use of cannabinoids is gradually increasing, particularly in patients where conventional treatments fail. Muscle pain is a major clinical problem and new pharmacological approaches are being studied. Recently, we have demonstrated that cannabinoid synthetic agonists are useful to reduce muscular pain in two animal models, where the local administration is effective. Now, we want to know if tetrahydrocannabinol (THC), a cannabinoid natural derivative with therapeutic use in humans, is also effective in reducing acute muscle pain. The antinociceptive effect of THC by systemic (i.p.) and local (i.m.) administration was tested in two animal models of acute muscle pain, rat masseter and gastrocnemius, induced by hypertonic saline (HS) injection. The drugs used were the non-selective agonist THC and two selective cannabinoid antagonists, AM251 (CB1) and AM630 (CB2). THC, i.p. and i.m. administered, reduced the nociceptive behaviours induced by HS in both muscular pain models. The antinociceptive effect induced by the systemic administration of THC was mediated by CB1 receptors in the masseter muscle whereas in gastrocnemius both CB1 and CB2 receptors participated. When THC was administered locally, only CB2 receptors were involved in the antinociceptive effect in both muscles. This study suggests that THC could be a future pharmacological option in the treatment of muscle pain. The local administration of THC could be an interesting option to treat this type of pain avoiding the central adverse effects. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/25446925/Involvement_of_central_and_peripheral_cannabinoid_receptors_on_antinociceptive_effect_of_tetrahydrocannabinol_in_muscle_pain_ DB - PRIME DP - Unbound Medicine ER -