Tags

Type your tag names separated by a space and hit enter

Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway.
Fitoterapia. 2015 Jan; 100:35-43.F

Abstract

Gelsemium, a small genus of flowering plant from the family Loganiaceae, comprises five species including the popular Gelsemium sempervirens Ait. and Gelsemium elegans Benth., which are indigenous to North America and China/East Asia, respectively. Approximately 120 alkaloids have been isolated and identified from Gelsemium, with the predominant indole alkaloids including gelsemine, koumine, gelsemicine, gelsenicine, gelsedine, sempervirine, koumidine, koumicine and humantenine. Gelsemine is the principal active alkaloid in G. sempervirens Ait., and koumine and gelsemine are the most and second-most dominant alkaloids in G. elegans Benth. Gelsemium extract and its active alkaloids serve a variety of biological functions, including neurobiological, immunosuppressive and antitumor effects, and have traditionally been used to treat pain, neuralgia, anxiety, insomnia, asthma, respiratory ailments and cancers. This review focuses on animal-based studies of Gelsemium as a pain treatment and its mechanism of action. In contrast to morphine, when administered intrathecally and systemically, koumine, gelsemine and gelsenicine have marked antinociception in inflammatory, neuropathic and bone cancer pains without inducing antinociceptive tolerance. Gelsemium and its active alkaloids may produce antinociception by activating the spinal α3 glycine/allopregnanolone pathway. The results of this review support the clinical use of Gelsemium and suggest that its active alkaloids may be developed to treat intractable and other types of pain, preferably after chemical modification. However, Gelsemium is a known toxic plant, and its toxicity limits its appropriate dosage and clinical use. To avoid or decrease the side/toxic effects of Gelsemium, an individual monomer of highly potent alkaloids must be selected, or alkaloids that exhibit greater α3 glycine receptor selectivity may be discovered or modified.

Authors+Show Affiliations

King's Lab, Shanghai Jiao Tong University School of Pharmacy, No 6 Biomedicine Building, 800 Dongchuan Road, Shanghai 200240, China.King's Lab, Shanghai Jiao Tong University School of Pharmacy, No 6 Biomedicine Building, 800 Dongchuan Road, Shanghai 200240, China. Electronic address: yxwang@sjtu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25447163

Citation

Zhang, Jing-Yang, and Yong-Xiang Wang. "Gelsemium Analgesia and the Spinal Glycine Receptor/allopregnanolone Pathway." Fitoterapia, vol. 100, 2015, pp. 35-43.
Zhang JY, Wang YX. Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway. Fitoterapia. 2015;100:35-43.
Zhang, J. Y., & Wang, Y. X. (2015). Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway. Fitoterapia, 100, 35-43. https://doi.org/10.1016/j.fitote.2014.11.002
Zhang JY, Wang YX. Gelsemium Analgesia and the Spinal Glycine Receptor/allopregnanolone Pathway. Fitoterapia. 2015;100:35-43. PubMed PMID: 25447163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway. AU - Zhang,Jing-Yang, AU - Wang,Yong-Xiang, Y1 - 2014/11/11/ PY - 2014/08/07/received PY - 2014/10/30/revised PY - 2014/11/01/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/5/21/medline KW - 3α-Hydroxysteroid oxidoreductase (3α-HSOR) KW - Allopregnanolone (3α,5α-THP) KW - Analgesia KW - Chronic pain KW - Gelsedine (PubChem CID: 251002) KW - Gelsemicine (PubChem CID: 5462428) KW - Gelsemine (PubChem CID: 279057) KW - Gelsemium KW - Gelsenicine (PubChem CID: 21123652) KW - Gelsevirine (PubChem CID: 14217344) KW - Glycine receptor KW - Humantenine (PubChem CID: 44593672) KW - Koumidine (PubChem CID: 44584550) KW - Koumine (PubChem CID: 44583834) KW - Sempevirine (PubChem CID: 168919) KW - Strychnine (PubChem CID: 441071) SP - 35 EP - 43 JF - Fitoterapia JO - Fitoterapia VL - 100 N2 - Gelsemium, a small genus of flowering plant from the family Loganiaceae, comprises five species including the popular Gelsemium sempervirens Ait. and Gelsemium elegans Benth., which are indigenous to North America and China/East Asia, respectively. Approximately 120 alkaloids have been isolated and identified from Gelsemium, with the predominant indole alkaloids including gelsemine, koumine, gelsemicine, gelsenicine, gelsedine, sempervirine, koumidine, koumicine and humantenine. Gelsemine is the principal active alkaloid in G. sempervirens Ait., and koumine and gelsemine are the most and second-most dominant alkaloids in G. elegans Benth. Gelsemium extract and its active alkaloids serve a variety of biological functions, including neurobiological, immunosuppressive and antitumor effects, and have traditionally been used to treat pain, neuralgia, anxiety, insomnia, asthma, respiratory ailments and cancers. This review focuses on animal-based studies of Gelsemium as a pain treatment and its mechanism of action. In contrast to morphine, when administered intrathecally and systemically, koumine, gelsemine and gelsenicine have marked antinociception in inflammatory, neuropathic and bone cancer pains without inducing antinociceptive tolerance. Gelsemium and its active alkaloids may produce antinociception by activating the spinal α3 glycine/allopregnanolone pathway. The results of this review support the clinical use of Gelsemium and suggest that its active alkaloids may be developed to treat intractable and other types of pain, preferably after chemical modification. However, Gelsemium is a known toxic plant, and its toxicity limits its appropriate dosage and clinical use. To avoid or decrease the side/toxic effects of Gelsemium, an individual monomer of highly potent alkaloids must be selected, or alkaloids that exhibit greater α3 glycine receptor selectivity may be discovered or modified. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/25447163/Gelsemium_analgesia_and_the_spinal_glycine_receptor/allopregnanolone_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(14)00289-5 DB - PRIME DP - Unbound Medicine ER -