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Pre-administration of curcumin prevents neonatal sevoflurane exposure-induced neurobehavioral abnormalities in mice.
Neurotoxicology. 2015 Jan; 46:155-64.N

Abstract

Sevoflurane, a commonly used inhaled anesthetic, can induce neuronal apoptosis in the developing rodent brain and correlate with functional neurological impairment later in life. However, the mechanisms underlying these deleterious effects of sevoflurane remain unclear and no effective treatment is currently available. Herein, the authors investigated whether curcumin can prevent the sevoflurane anesthesia-induced cognitive impairment in mice. Six-day-old C57BL/6 mice were exposed to 3% sevoflurane 2h daily for 3 consecutive days and were treated with curcumin at the dose of 20 mg/kg or vehicle 30 min before the sevoflurane anesthesia from postnatal days 6 (P6) to P8. Cognitive functions were evaluated by open field, Morris water maze, and fear conditioning tests on P61, P63-69, and P77-78, respectively. In another separate experiment, mice were killed on day P8 or P78, and the brain tissues were harvested and then subjected to biochemistry studies. Our results showed that repeated neonatal sevoflurane exposure led to significant cognitive impairment later in life, which was associated with increased neuronal apoptosis, neuroinflammation, oxidative nitrosative stress, and decreased memory related proteins. By contrast, pre-administration of curcumin ameliorated early neuronal apoptosis, neuroinflammation, oxidative nitrosative stress, memory related proteins, and later cognitive dysfunction. In conclusion, our data suggested that curcumin pre-administration can prevent the sevoflurane exposure-induced cognitive impairment later in life, which may be partly attributed to its ability to attenuate the neural apoptosis, inflammation, and oxidative nitrosative stress in mouse brain.

Authors+Show Affiliations

Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou, China.Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou, China. Electronic address: weiyanlee@sina.com.Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou, China. Electronic address: yjyangjj@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25447320

Citation

Ji, Mu-Huo, et al. "Pre-administration of Curcumin Prevents Neonatal Sevoflurane Exposure-induced Neurobehavioral Abnormalities in Mice." Neurotoxicology, vol. 46, 2015, pp. 155-64.
Ji MH, Qiu LL, Yang JJ, et al. Pre-administration of curcumin prevents neonatal sevoflurane exposure-induced neurobehavioral abnormalities in mice. Neurotoxicology. 2015;46:155-64.
Ji, M. H., Qiu, L. L., Yang, J. J., Zhang, H., Sun, X. R., Zhu, S. H., Li, W. Y., & Yang, J. J. (2015). Pre-administration of curcumin prevents neonatal sevoflurane exposure-induced neurobehavioral abnormalities in mice. Neurotoxicology, 46, 155-64. https://doi.org/10.1016/j.neuro.2014.11.003
Ji MH, et al. Pre-administration of Curcumin Prevents Neonatal Sevoflurane Exposure-induced Neurobehavioral Abnormalities in Mice. Neurotoxicology. 2015;46:155-64. PubMed PMID: 25447320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-administration of curcumin prevents neonatal sevoflurane exposure-induced neurobehavioral abnormalities in mice. AU - Ji,Mu-Huo, AU - Qiu,Li-Li, AU - Yang,Jiao-Jiao, AU - Zhang,Hui, AU - Sun,Xiao-Ru, AU - Zhu,Si-Hai, AU - Li,Wei-Yan, AU - Yang,Jian-Jun, Y1 - 2014/11/15/ PY - 2014/09/05/received PY - 2014/11/06/revised PY - 2014/11/09/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/11/13/medline KW - Cognition KW - Curcumin KW - Neurotoxicity KW - Sevoflurane SP - 155 EP - 64 JF - Neurotoxicology JO - Neurotoxicology VL - 46 N2 - Sevoflurane, a commonly used inhaled anesthetic, can induce neuronal apoptosis in the developing rodent brain and correlate with functional neurological impairment later in life. However, the mechanisms underlying these deleterious effects of sevoflurane remain unclear and no effective treatment is currently available. Herein, the authors investigated whether curcumin can prevent the sevoflurane anesthesia-induced cognitive impairment in mice. Six-day-old C57BL/6 mice were exposed to 3% sevoflurane 2h daily for 3 consecutive days and were treated with curcumin at the dose of 20 mg/kg or vehicle 30 min before the sevoflurane anesthesia from postnatal days 6 (P6) to P8. Cognitive functions were evaluated by open field, Morris water maze, and fear conditioning tests on P61, P63-69, and P77-78, respectively. In another separate experiment, mice were killed on day P8 or P78, and the brain tissues were harvested and then subjected to biochemistry studies. Our results showed that repeated neonatal sevoflurane exposure led to significant cognitive impairment later in life, which was associated with increased neuronal apoptosis, neuroinflammation, oxidative nitrosative stress, and decreased memory related proteins. By contrast, pre-administration of curcumin ameliorated early neuronal apoptosis, neuroinflammation, oxidative nitrosative stress, memory related proteins, and later cognitive dysfunction. In conclusion, our data suggested that curcumin pre-administration can prevent the sevoflurane exposure-induced cognitive impairment later in life, which may be partly attributed to its ability to attenuate the neural apoptosis, inflammation, and oxidative nitrosative stress in mouse brain. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/25447320/Pre_administration_of_curcumin_prevents_neonatal_sevoflurane_exposure_induced_neurobehavioral_abnormalities_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(14)00186-7 DB - PRIME DP - Unbound Medicine ER -