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Impact of the pneumococcal conjugate vaccines on invasive pneumococcal disease in France, 2001-2012.
Vaccine. 2015 Jan 03; 33(2):359-66.V

Abstract

CONTEXT AND AIMS

Vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7) was recommended in France in 2003 for children <2 years. The 13-valent conjugate vaccine (PCV13) replaced PCV7 in 2010. We assessed the impact of PCVs vaccination on the incidence of invasive pneumococcal diseases (IPD) in French children (0-15 years) and adults (>15 years).

METHODS

IPD rates were calculated using cases reported from 2001 to 2012 to Epibac, a laboratory network. The distribution of serotypes was assessed from invasive isolates serotyped at the National reference Centre for Pneumococci. IPD incidence rates were compared between the pre-PCV7 (2001-2002), late PCV7 (2008-2009) and post PCV13 (2012) periods.

RESULTS

The PCVs coverage increased from 56% in the 2004 birth-cohort to 94% in the 2008 and following birth-cohorts. Following PCV7 introduction, IPD incidence decreased by 19% between 2001-2002 and 2008-2009 in children <2 years, but increased in children aged 2-15 years and adults, despite a sharp decline in PCV7-IPD in all age-groups. After PCV13 introduction, IPD incidence decreased by 34% in children <5 years, by 50% in those aged 5-15 years and 15% in adults from 2008-2009 to 2012. The incidence of PCV13-Non PCV7-IPD decreased by 74% in children <5 years and by 60% in those aged 5-15 years.

CONCLUSIONS

Vaccination with PCV13 was rapidly followed by a decrease in the incidence of all-type IPD in children, in relation with a sharp decrease in the incidence of PCV13-Non PCV7-IPD. Moreover, all-type IPD decreased after PCV13 introduction in older non-vaccinated age-groups, with a shift in the distribution of serotypes. Considering the whole 2001-2012 period, the vaccination with PCV7 and PCV13 resulted in a decline in the incidence of IPD in children up to the age of 5 but not in older children and adults.

Authors+Show Affiliations

Département des maladies infectieuses, Institut de Veille Sanitaire, Saint Maurice, France. Electronic address: a.lepoutre@invs.sante.fr.Centre National de Référence des Pneumocoques, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.Département des maladies infectieuses, Institut de Veille Sanitaire, Saint Maurice, France.Département des maladies infectieuses, Institut de Veille Sanitaire, Saint Maurice, France.Centre National de Référence des Pneumocoques, AP-HP, Hôpital Européen Georges Pompidou, Paris, France; Université Paris Sud, EA 4043 Châtenay-Malabry, France.Centre National de Référence des Pneumocoques, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.Département des maladies infectieuses, Institut de Veille Sanitaire, Saint Maurice, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25448105

Citation

Lepoutre, A, et al. "Impact of the Pneumococcal Conjugate Vaccines On Invasive Pneumococcal Disease in France, 2001-2012." Vaccine, vol. 33, no. 2, 2015, pp. 359-66.
Lepoutre A, Varon E, Georges S, et al. Impact of the pneumococcal conjugate vaccines on invasive pneumococcal disease in France, 2001-2012. Vaccine. 2015;33(2):359-66.
Lepoutre, A., Varon, E., Georges, S., Dorléans, F., Janoir, C., Gutmann, L., & Lévy-Bruhl, D. (2015). Impact of the pneumococcal conjugate vaccines on invasive pneumococcal disease in France, 2001-2012. Vaccine, 33(2), 359-66. https://doi.org/10.1016/j.vaccine.2014.11.011
Lepoutre A, et al. Impact of the Pneumococcal Conjugate Vaccines On Invasive Pneumococcal Disease in France, 2001-2012. Vaccine. 2015 Jan 3;33(2):359-66. PubMed PMID: 25448105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of the pneumococcal conjugate vaccines on invasive pneumococcal disease in France, 2001-2012. AU - Lepoutre,A, AU - Varon,E, AU - Georges,S, AU - Dorléans,F, AU - Janoir,C, AU - Gutmann,L, AU - Lévy-Bruhl,D, AU - ,, AU - ,, Y1 - 2014/11/20/ PY - 2014/07/11/received PY - 2014/10/15/revised PY - 2014/11/10/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2016/1/24/medline KW - France KW - Invasive pneumococcal disease KW - Pneumococcal conjugate vaccines KW - Population surveillance KW - Serotype replacement KW - Vaccine impact SP - 359 EP - 66 JF - Vaccine JO - Vaccine VL - 33 IS - 2 N2 - CONTEXT AND AIMS: Vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7) was recommended in France in 2003 for children <2 years. The 13-valent conjugate vaccine (PCV13) replaced PCV7 in 2010. We assessed the impact of PCVs vaccination on the incidence of invasive pneumococcal diseases (IPD) in French children (0-15 years) and adults (>15 years). METHODS: IPD rates were calculated using cases reported from 2001 to 2012 to Epibac, a laboratory network. The distribution of serotypes was assessed from invasive isolates serotyped at the National reference Centre for Pneumococci. IPD incidence rates were compared between the pre-PCV7 (2001-2002), late PCV7 (2008-2009) and post PCV13 (2012) periods. RESULTS: The PCVs coverage increased from 56% in the 2004 birth-cohort to 94% in the 2008 and following birth-cohorts. Following PCV7 introduction, IPD incidence decreased by 19% between 2001-2002 and 2008-2009 in children <2 years, but increased in children aged 2-15 years and adults, despite a sharp decline in PCV7-IPD in all age-groups. After PCV13 introduction, IPD incidence decreased by 34% in children <5 years, by 50% in those aged 5-15 years and 15% in adults from 2008-2009 to 2012. The incidence of PCV13-Non PCV7-IPD decreased by 74% in children <5 years and by 60% in those aged 5-15 years. CONCLUSIONS: Vaccination with PCV13 was rapidly followed by a decrease in the incidence of all-type IPD in children, in relation with a sharp decrease in the incidence of PCV13-Non PCV7-IPD. Moreover, all-type IPD decreased after PCV13 introduction in older non-vaccinated age-groups, with a shift in the distribution of serotypes. Considering the whole 2001-2012 period, the vaccination with PCV7 and PCV13 resulted in a decline in the incidence of IPD in children up to the age of 5 but not in older children and adults. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/25448105/Impact_of_the_pneumococcal_conjugate_vaccines_on_invasive_pneumococcal_disease_in_France_2001_2012_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(14)01535-7 DB - PRIME DP - Unbound Medicine ER -