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Association of lung function with coronary heart disease and cardiovascular disease outcomes in elderly: the Rancho Bernardo study.
Respir Med 2014; 108(12):1779-85RM

Abstract

INTRODUCTION

Lung function is inversely associated with coronary heart disease (CHD) and cardiovascular disease (CVD). We evaluated the prospective association of reduced lung function by spirometry and CHD or CVD events in older community-dwelling adults.

METHODS

We studied 1548 participants (mean age 73.6 ± 9.2 years, 42% males) from the Rancho Bernardo Study using age, sex, and risk-factor adjusted Cox regression to assess pulmonary function (FEV1, FVC, and FEV1/FVC ratio) as a predictor of CHD and CVD events followed for up to 22 years.

RESULTS

Of CVD risk factors, older age, male sex, current/past smoking, physical exercise (<3× a week), and prevalent CVD predicted an increased risk of CHD and CVD. Higher FEV1 and FVC were each associated with a decreased risk of CHD [HR 0.80 (0.73-0.88) for both FEV1 and FVC, per SD, p < 0.01] and CVD [HR 0.82 (0.74-0.91) for both FEV1 and FVC, per SD, p < 0.01]. Those in the lowest quartiles of FEV1 and FVC had hazard ratios of 1.68 (1.33-2.13) and 1.55 (1.21-2.00) respectively for CHD and 1.74 (1.34-2.25) and 1.49 (1.13-1.96) respectively for CVD (all p < 0.01, relative to those in the highest quartile). Similar findings were observed for CHD and CVD mortality. Sex- and age-stratified analyses showed the strongest associations for CHD and CVD events in women and in the oldest participants.

CONCLUSIONS

FEV1 and FVC are inversely associated with risk of future CHD and CVD events in older community-dwelling adults and may add to CVD risk stratification in the elderly.

Authors+Show Affiliations

Division of Pulmonary and Critical Care Medicine, University of California, Irvine, CA, USA; Heart Disease Prevention Program, University of California, Irvine, CA, USA. Electronic address: leehwamumd@gmail.com.Heart Disease Prevention Program, University of California, Irvine, CA, USA.Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA.Heart Disease Prevention Program, University of California, Irvine, CA, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25448311

Citation

Lee, Hwa Mu, et al. "Association of Lung Function With Coronary Heart Disease and Cardiovascular Disease Outcomes in Elderly: the Rancho Bernardo Study." Respiratory Medicine, vol. 108, no. 12, 2014, pp. 1779-85.
Lee HM, Liu MA, Barrett-Connor E, et al. Association of lung function with coronary heart disease and cardiovascular disease outcomes in elderly: the Rancho Bernardo study. Respir Med. 2014;108(12):1779-85.
Lee, H. M., Liu, M. A., Barrett-Connor, E., & Wong, N. D. (2014). Association of lung function with coronary heart disease and cardiovascular disease outcomes in elderly: the Rancho Bernardo study. Respiratory Medicine, 108(12), pp. 1779-85. doi:10.1016/j.rmed.2014.09.016.
Lee HM, et al. Association of Lung Function With Coronary Heart Disease and Cardiovascular Disease Outcomes in Elderly: the Rancho Bernardo Study. Respir Med. 2014;108(12):1779-85. PubMed PMID: 25448311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of lung function with coronary heart disease and cardiovascular disease outcomes in elderly: the Rancho Bernardo study. AU - Lee,Hwa Mu, AU - Liu,Michael A, AU - Barrett-Connor,Elizabeth, AU - Wong,Nathan D, Y1 - 2014/10/06/ PY - 2014/06/11/received PY - 2014/09/16/revised PY - 2014/09/26/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/7/15/medline KW - Cardiovascular disease KW - Coronary heart disease KW - Epidemiology KW - Pulmonary function test SP - 1779 EP - 85 JF - Respiratory medicine JO - Respir Med VL - 108 IS - 12 N2 - INTRODUCTION: Lung function is inversely associated with coronary heart disease (CHD) and cardiovascular disease (CVD). We evaluated the prospective association of reduced lung function by spirometry and CHD or CVD events in older community-dwelling adults. METHODS: We studied 1548 participants (mean age 73.6 ± 9.2 years, 42% males) from the Rancho Bernardo Study using age, sex, and risk-factor adjusted Cox regression to assess pulmonary function (FEV1, FVC, and FEV1/FVC ratio) as a predictor of CHD and CVD events followed for up to 22 years. RESULTS: Of CVD risk factors, older age, male sex, current/past smoking, physical exercise (<3× a week), and prevalent CVD predicted an increased risk of CHD and CVD. Higher FEV1 and FVC were each associated with a decreased risk of CHD [HR 0.80 (0.73-0.88) for both FEV1 and FVC, per SD, p < 0.01] and CVD [HR 0.82 (0.74-0.91) for both FEV1 and FVC, per SD, p < 0.01]. Those in the lowest quartiles of FEV1 and FVC had hazard ratios of 1.68 (1.33-2.13) and 1.55 (1.21-2.00) respectively for CHD and 1.74 (1.34-2.25) and 1.49 (1.13-1.96) respectively for CVD (all p < 0.01, relative to those in the highest quartile). Similar findings were observed for CHD and CVD mortality. Sex- and age-stratified analyses showed the strongest associations for CHD and CVD events in women and in the oldest participants. CONCLUSIONS: FEV1 and FVC are inversely associated with risk of future CHD and CVD events in older community-dwelling adults and may add to CVD risk stratification in the elderly. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/25448311/Association_of_lung_function_with_coronary_heart_disease_and_cardiovascular_disease_outcomes_in_elderly:_the_Rancho_Bernardo_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(14)00327-8 DB - PRIME DP - Unbound Medicine ER -