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Phosphoinositides: Lipids with informative heads and mastermind functions in cell division.
Biochim Biophys Acta. 2015 Jun; 1851(6):832-43.BB

Abstract

Phosphoinositides are low abundant but essential phospholipids in eukaryotic cells and refer to phosphatidylinositol and its seven polyphospho-derivatives. In this review, we summarize our current knowledge on phosphoinositides in multiple aspects of cell division in animal cells, including mitotic cell rounding, longitudinal cell elongation, cytokinesis furrow ingression, intercellular bridge abscission and post-cytokinesis events. PtdIns(4,5)P₂production plays critical roles in spindle orientation, mitotic cell shape and bridge stability after furrow ingression by recruiting force generator complexes and numerous cytoskeleton binding proteins. Later, PtdIns(4,5)P₂hydrolysis and PtdIns3P production are essential for normal cytokinesis abscission. Finally, emerging functions of PtdIns3P and likely PtdIns(4,5)P₂have recently been reported for midbody remnant clearance after abscission. We describe how the multiple functions of phosphoinositides in cell division reflect their distinct roles in local recruitment of protein complexes, membrane traffic and cytoskeleton remodeling. This article is part of a Special Issue entitled Phosphoinositides.

Authors+Show Affiliations

Institut Pasteur, Membrane Traffic and Cell Division Lab., 28 rue du Dr Roux, 75015 Paris, France; CNRS URA2582, France; Sorbonne Universités, UPMC Univ Paris06, IFD, 4 Place Jussieu, 75252 Paris cedex05, France.Institut Pasteur, Membrane Traffic and Cell Division Lab., 28 rue du Dr Roux, 75015 Paris, France; CNRS URA2582, France. Electronic address: arnaud.echard@pasteur.fr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25449648

Citation

Cauvin, Clothilde, and Arnaud Echard. "Phosphoinositides: Lipids With Informative Heads and Mastermind Functions in Cell Division." Biochimica Et Biophysica Acta, vol. 1851, no. 6, 2015, pp. 832-43.
Cauvin C, Echard A. Phosphoinositides: Lipids with informative heads and mastermind functions in cell division. Biochim Biophys Acta. 2015;1851(6):832-43.
Cauvin, C., & Echard, A. (2015). Phosphoinositides: Lipids with informative heads and mastermind functions in cell division. Biochimica Et Biophysica Acta, 1851(6), 832-43. https://doi.org/10.1016/j.bbalip.2014.10.013
Cauvin C, Echard A. Phosphoinositides: Lipids With Informative Heads and Mastermind Functions in Cell Division. Biochim Biophys Acta. 2015;1851(6):832-43. PubMed PMID: 25449648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phosphoinositides: Lipids with informative heads and mastermind functions in cell division. AU - Cauvin,Clothilde, AU - Echard,Arnaud, Y1 - 2014/11/04/ PY - 2014/07/22/received PY - 2014/10/21/revised PY - 2014/10/28/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/8/26/medline KW - Cell division KW - Cytokinesis KW - Midbody KW - Phosphoinositide KW - PtdIns(4,5)P2 KW - Spindle orientation SP - 832 EP - 43 JF - Biochimica et biophysica acta JO - Biochim Biophys Acta VL - 1851 IS - 6 N2 - Phosphoinositides are low abundant but essential phospholipids in eukaryotic cells and refer to phosphatidylinositol and its seven polyphospho-derivatives. In this review, we summarize our current knowledge on phosphoinositides in multiple aspects of cell division in animal cells, including mitotic cell rounding, longitudinal cell elongation, cytokinesis furrow ingression, intercellular bridge abscission and post-cytokinesis events. PtdIns(4,5)P₂production plays critical roles in spindle orientation, mitotic cell shape and bridge stability after furrow ingression by recruiting force generator complexes and numerous cytoskeleton binding proteins. Later, PtdIns(4,5)P₂hydrolysis and PtdIns3P production are essential for normal cytokinesis abscission. Finally, emerging functions of PtdIns3P and likely PtdIns(4,5)P₂have recently been reported for midbody remnant clearance after abscission. We describe how the multiple functions of phosphoinositides in cell division reflect their distinct roles in local recruitment of protein complexes, membrane traffic and cytoskeleton remodeling. This article is part of a Special Issue entitled Phosphoinositides. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/25449648/Phosphoinositides:_Lipids_with_informative_heads_and_mastermind_functions_in_cell_division_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-1981(14)00222-4 DB - PRIME DP - Unbound Medicine ER -